Chlorine in PDB 8fqh: Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 150MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA260)

The binding sites of Chlorine atom in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 150MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA260) (pdb code 8fqh). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 150MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA260), PDB code: 8fqh:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 150MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA260)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 150MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA260) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1302 b:73.8 occ:1.00 CL A:CYZ1302 0.0 73.8 1.0 C13 A:CYZ1302 1.8 51.1 1.0 C12 A:CYZ1302 2.8 47.0 1.0 C14 A:CYZ1302 2.8 40.6 1.0 O4 A:CYZ1302 2.9 51.4 1.0 O A:HOH1401 2.9 10.7 1.0 S2 A:CYZ1302 3.2 66.2 1.0 N A:ASP760 3.4 41.6 1.0 CB A:LEU759 3.5 39.5 1.0 N3 A:CYZ1302 3.6 47.8 1.0 C A:LEU759 3.7 37.5 1.0 CA A:ASP760 3.7 50.2 1.0 C11 A:CYZ1302 4.0 37.2 1.0 CB A:ASP760 4.1 49.5 1.0 O A:LEU759 4.1 45.0 1.0 C10 A:CYZ1302 4.1 39.9 1.0 CA A:LEU759 4.2 34.7 1.0 C9 A:CYZ1302 4.6 42.5 1.0 CG A:ASP760 4.6 52.2 1.0 O A:PHE495 4.7 39.7 1.0 CD1 A:LEU759 4.7 39.6 1.0 CG A:LEU759 4.7 38.1 1.0 OD2 A:ASP760 4.7 46.1 1.0 O3 A:CYZ1302 4.8 51.4 1.0

Chlorine binding site 2 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 150MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA260)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 150MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA260) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1303 b:77.8 occ:1.00 CL A:CYZ1303 0.0 77.8 1.0 C13 A:CYZ1303 1.8 63.6 1.0 C12 A:CYZ1303 2.7 61.1 1.0 C14 A:CYZ1303 2.8 63.0 1.0 O4 A:CYZ1303 2.9 69.3 1.0 S2 A:CYZ1303 3.1 69.5 1.0 CB D:LEU759 3.4 41.6 1.0 N3 A:CYZ1303 3.5 60.7 1.0 C D:LEU759 3.7 37.2 1.0 O D:PHE495 3.8 56.2 1.0 O D:LEU759 3.8 44.2 1.0 N D:ASP760 3.9 42.4 1.0 OD2 D:ASP760 3.9 59.1 1.0 C11 A:CYZ1303 4.0 65.7 1.0 C10 A:CYZ1303 4.1 56.0 1.0 CA D:LEU759 4.2 41.1 1.0 CD1 D:LEU759 4.3 31.9 1.0 CA D:ASP760 4.3 49.8 1.0 CG D:LEU759 4.4 29.2 1.0 CG D:ASP760 4.4 57.0 1.0 C9 A:CYZ1303 4.6 62.8 1.0 OH D:TYR424 4.6 56.3 1.0 O3 A:CYZ1303 4.7 66.2 1.0 CB D:LYS763 4.8 56.2 1.0 CD2 D:LEU759 4.8 32.9 1.0 OD1 D:ASP760 4.9 53.3 1.0 C D:PHE495 4.9 53.9 1.0 CB A:SER729 4.9 70.3 1.0

Chlorine binding site 3 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 150MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA260)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 150MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA260) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1302 b:75.5 occ:1.00 CL B:CYZ1302 0.0 75.5 1.0 C13 B:CYZ1302 1.8 55.5 1.0 C12 B:CYZ1302 2.7 51.1 1.0 C14 B:CYZ1302 2.8 55.4 1.0 O4 B:CYZ1302 3.1 63.5 1.0 S2 B:CYZ1302 3.2 70.2 1.0 OD2 B:ASP760 3.2 59.1 1.0 CG B:ASP760 3.2 61.5 1.0 OD1 B:ASP760 3.3 58.1 1.0 N3 B:CYZ1302 3.3 53.4 1.0 N B:ASP760 3.4 47.2 1.0 CB B:LEU759 3.6 39.2 1.0 C B:LEU759 3.7 41.4 1.0 CA B:ASP760 3.7 55.1 1.0 C11 B:CYZ1302 4.0 54.4 1.0 CB B:ASP760 4.0 59.4 1.0 O B:LEU759 4.1 48.4 1.0 C10 B:CYZ1302 4.1 51.1 1.0 CA B:LEU759 4.2 42.9 1.0 C9 B:CYZ1302 4.6 53.3 1.0 O B:PHE495 4.8 50.6 1.0 O3 B:CYZ1302 4.8 60.0 1.0 CG B:LEU759 4.8 37.8 1.0 CD1 B:LEU759 4.8 40.9 1.0

Chlorine binding site 4 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 150MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA260)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 150MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA260) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1302 b:77.3 occ:1.00 CL C:CYZ1302 0.0 77.3 1.0 C13 C:CYZ1302 1.8 56.5 1.0 C12 C:CYZ1302 2.7 51.3 1.0 C14 C:CYZ1302 2.8 49.9 1.0 O4 C:CYZ1302 2.9 55.5 1.0 O C:HOH1401 3.2 24.2 1.0 N C:ASP760 3.2 38.8 1.0 S2 C:CYZ1302 3.2 72.2 1.0 CB C:LEU759 3.5 40.8 1.0 CA C:ASP760 3.5 47.3 1.0 C C:LEU759 3.5 37.8 1.0 N3 C:CYZ1302 3.6 54.3 1.0 CB C:ASP760 3.8 48.5 1.0 C11 C:CYZ1302 4.0 42.2 1.0 O C:LEU759 4.0 47.0 1.0 C10 C:CYZ1302 4.1 48.8 1.0 CA C:LEU759 4.1 36.0 1.0 CG C:ASP760 4.5 53.0 1.0 OD2 C:ASP760 4.5 48.1 1.0 C9 C:CYZ1302 4.6 49.9 1.0 CG C:LEU759 4.7 40.7 1.0 O C:PHE495 4.7 41.6 1.0 CD1 C:LEU759 4.7 42.0 1.0 O3 C:CYZ1302 4.8 57.8 1.0 N C:LEU759 4.9 50.0 1.0 C C:ASP760 5.0 58.9 1.0

T.Nakagawa, X.Wang, F.J.Miguez-Cabello, D.Bowie. Open Gate of Ampa Receptor Is A CA2+ Binding Site Critical to Ion Transport To Be Published.