Chlorine in PDB 8ga1: Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Swap

The binding sites of Chlorine atom in the Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Swap (pdb code 8ga1). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Swap, PDB code: 8ga1:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Swap


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Swap within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl501 b:6.3 occ:1.00 OH A:TYR445 2.5 6.3 1.0 OG A:SER107 2.7 4.6 1.0 N A:ILE356 3.2 5.8 1.0 CZ A:TYR445 3.4 6.3 1.0 CA A:GLY355 3.5 5.4 1.0 CB A:SER107 3.5 4.6 1.0 N A:PHE357 3.5 6.8 1.0 CE1 A:TYR445 3.6 6.3 1.0 CB A:PHE357 3.7 6.8 1.0 CD1 A:ILE109 3.8 5.5 1.0 C A:GLY355 3.9 5.4 1.0 CG2 A:ILE356 4.2 5.8 1.0 CA A:PHE357 4.2 6.8 1.0 CA A:ILE356 4.2 5.8 1.0 C A:ILE356 4.3 5.8 1.0 CA A:SER107 4.4 4.6 1.0 CG1 A:ILE109 4.4 5.5 1.0 CG A:GLU148 4.5 7.4 1.0 OE2 A:GLU148 4.6 7.4 1.0 CA A:GLY149 4.6 6.0 1.0 CE2 A:TYR445 4.7 6.3 1.0 CB A:ILE356 4.7 5.8 1.0 CG A:PHE357 4.7 6.8 1.0 N A:GLY149 4.8 6.0 1.0 N A:GLY355 4.8 5.4 1.0 CE1 A:PHE348 4.8 5.5 1.0 CD2 A:PHE357 4.8 6.8 1.0 CD1 A:TYR445 4.9 6.3 1.0 CB A:ILE109 5.0 5.5 1.0

Chlorine binding site 2 out of 4 in the Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Swap


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Swap within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl502 b:3.5 occ:1.00 N A:SER107 3.0 4.6 1.0 CG2 A:ILE448 3.6 7.1 1.0 CZ A:PHE348 3.7 5.5 1.0 CB A:SER107 3.7 4.6 1.0 CA A:GLY106 3.8 5.0 1.0 C A:GLY106 3.8 5.0 1.0 CA A:SER107 3.9 4.6 1.0 CG A:PRO110 4.0 6.5 1.0 O A:GLY105 4.2 6.3 1.0 N A:GLY108 4.2 5.2 1.0 CE1 A:PHE348 4.3 5.5 1.0 CD A:PRO110 4.4 6.5 1.0 CE2 A:PHE348 4.4 5.5 1.0 CB A:ILE448 4.5 7.1 1.0 CG1 A:ILE448 4.6 7.1 1.0 C A:SER107 4.6 4.6 1.0 CD1 A:ILE448 4.8 7.1 1.0 N A:GLY106 4.9 5.0 1.0 C A:GLY105 5.0 6.3 1.0

Chlorine binding site 3 out of 4 in the Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Swap


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Swap within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl501 b:7.4 occ:1.00 OH B:TYR445 2.4 6.7 1.0 OG B:SER107 2.7 5.8 1.0 N B:ILE356 3.4 6.2 1.0 CA B:GLY355 3.4 5.8 1.0 CZ B:TYR445 3.5 6.7 1.0 CB B:SER107 3.5 5.8 1.0 N B:PHE357 3.6 6.4 1.0 CB B:PHE357 3.7 6.4 1.0 CG1 B:ILE356 3.8 6.2 1.0 CD1 B:ILE109 3.8 6.1 1.0 CE1 B:TYR445 3.8 6.7 1.0 OE2 B:GLU148 3.9 7.4 1.0 C B:GLY355 3.9 5.8 1.0 CA B:PHE357 4.3 6.4 1.0 CG1 B:ILE109 4.3 6.1 1.0 CA B:ILE356 4.4 6.2 1.0 C B:ILE356 4.5 6.2 1.0 CD1 B:PHE357 4.5 6.4 1.0 CG B:GLU148 4.5 7.4 1.0 CA B:SER107 4.5 5.8 1.0 CA B:GLY149 4.5 6.9 1.0 CE2 B:TYR445 4.6 6.7 1.0 CG B:PHE357 4.6 6.4 1.0 CD1 B:ILE356 4.7 6.2 1.0 CD B:GLU148 4.7 7.4 1.0 N B:GLY149 4.7 6.9 1.0 N B:GLY355 4.7 5.8 1.0 CB B:ILE356 4.8 6.2 1.0 CB B:ILE109 5.0 6.1 1.0

Chlorine binding site 4 out of 4 in the Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Swap


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Swap within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl502 b:5.1 occ:1.00 N B:SER107 3.1 5.8 1.0 O B:HOH616 3.1 6.3 1.0 CB B:SER107 3.6 5.8 1.0 CZ B:PHE348 3.7 6.8 1.0 CG2 B:ILE448 3.7 8.2 1.0 CD B:PRO110 3.8 6.6 1.0 CA B:SER107 3.9 5.8 1.0 CG B:PRO110 3.9 6.6 1.0 C B:GLY106 4.0 6.2 1.0 CA B:GLY106 4.0 6.2 1.0 CD1 B:ILE448 4.0 8.2 1.0 N B:GLY108 4.1 5.8 1.0 CE1 B:PHE348 4.3 6.8 1.0 CE2 B:PHE348 4.5 6.8 1.0 C B:SER107 4.5 5.8 1.0 CB B:ILE448 4.6 8.2 1.0 O B:GLY105 4.6 7.2 1.0 CB B:PRO110 4.7 6.6 1.0 CG1 B:ILE448 4.7 8.2 1.0 OG B:SER107 4.9 5.8 1.0 O B:HOH620 5.0 6.1 1.0

E.Fortea, S.Lee, R.Chadda, Y.Argyros, P.Sandal, R.Mahoney-Kruszka, D.Ciftici, M.E.Falzone, G.Huysmans, J.L.Robertson, O.Boudker, A.Accardi. Structural Basis of pH-Dependent Activation in A Clc Transporter. Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
PubMed: 38279055
DOI: 10.1038/S41594-023-01210-5