Chlorine in PDB 8ga3: Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Turn

The binding sites of Chlorine atom in the Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Turn (pdb code 8ga3). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Turn, PDB code: 8ga3:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Turn


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Turn within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl501 b:41.5 occ:1.00 CB A:ALA358 3.5 27.9 1.0 N A:ARG147 3.6 29.4 1.0 CA A:GLY146 3.8 26.9 1.0 CG A:ARG147 3.8 29.4 1.0 CE2 A:PHE317 3.8 32.8 1.0 NH1 A:ARG147 3.8 29.4 1.0 CD2 A:PHE317 3.9 32.8 1.0 O A:LEU145 3.9 25.0 1.0 CD A:ARG147 4.2 29.4 1.0 C A:GLY146 4.2 26.9 1.0 CB A:ARG147 4.3 29.4 1.0 CA A:ARG147 4.5 29.4 1.0 CA A:GLY315 4.6 27.8 1.0 O A:GLY315 4.6 27.8 1.0 CZ A:PHE317 4.6 32.8 1.0 C A:GLY315 4.7 27.8 1.0 CG A:PHE317 4.8 32.8 1.0 N A:GLY146 4.8 26.9 1.0 C A:LEU145 4.8 25.0 1.0 CZ A:ARG147 4.8 29.4 1.0 CD2 A:LEU139 4.9 28.5 1.0 NE A:ARG147 4.9 29.4 1.0

Chlorine binding site 2 out of 4 in the Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Turn


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Turn within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl502 b:25.9 occ:1.00 N A:SER107 3.5 21.1 1.0 CG2 A:ILE448 3.5 20.4 1.0 CA A:GLY106 3.5 21.5 1.0 O A:GLY105 3.9 23.4 1.0 C A:GLY106 4.0 21.5 1.0 CA A:SER107 4.5 21.1 1.0 N A:GLY106 4.5 21.5 1.0 CZ A:PHE348 4.5 23.6 1.0 CB A:SER107 4.6 21.1 1.0 CD1 A:ILE448 4.6 20.4 1.0 N A:GLY108 4.6 20.5 1.0 C A:GLY105 4.6 23.4 1.0 CE1 A:PHE348 4.7 23.6 1.0 CG A:PRO110 4.8 21.2 1.0 CD A:PRO110 4.8 21.2 1.0 CB A:ILE448 4.8 20.4 1.0 NE2 A:GLN277 4.9 23.7 1.0

Chlorine binding site 3 out of 4 in the Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Turn


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Turn within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl501 b:23.8 occ:1.00 O B:LEU145 3.1 26.3 1.0 CD2 B:LEU139 3.6 28.7 1.0 CA B:GLY315 4.0 30.4 1.0 CG B:LEU139 4.2 28.7 1.0 C B:LEU145 4.2 26.3 1.0 N B:GLY315 4.3 30.4 1.0 CA B:GLY146 4.3 25.7 1.0 O B:GLY315 4.4 30.4 1.0 CB B:LEU139 4.5 28.7 1.0 C B:GLY315 4.6 30.4 1.0 O B:LEU139 4.8 28.7 1.0 C B:GLY146 4.8 25.7 1.0 N B:GLY146 4.8 25.7 1.0 N B:ARG147 4.8 27.6 1.0 NH1 B:ARG147 4.9 27.6 1.0 CD B:ARG147 4.9 27.6 1.0

Chlorine binding site 4 out of 4 in the Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Turn


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Clc-EC1 R230C/L249C/C85A at pH 4.5 100MM Cl Turn within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl502 b:28.0 occ:1.00 NE2 B:GLN277 3.5 28.2 1.0 CA B:GLY106 3.5 26.3 1.0 CZ B:PHE348 3.8 27.0 1.0 CE1 B:PHE348 3.9 27.0 1.0 CG2 B:ILE448 3.9 24.4 1.0 O B:GLY105 4.0 31.6 1.0 N B:SER107 4.1 23.4 1.0 O B:PHE348 4.3 27.0 1.0 C B:GLY106 4.4 26.3 1.0 CD B:GLN277 4.5 28.2 1.0 CE2 B:PHE348 4.5 27.0 1.0 N B:GLY106 4.5 26.3 1.0 CD1 B:PHE348 4.6 27.0 1.0 CD1 B:ILE448 4.6 24.4 1.0 C B:GLY105 4.7 31.6 1.0 OE1 B:GLN277 5.0 28.2 1.0 CG1 B:ILE448 5.0 24.4 1.0

E.Fortea, S.Lee, R.Chadda, Y.Argyros, P.Sandal, R.Mahoney-Kruszka, D.Ciftici, M.E.Falzone, G.Huysmans, J.L.Robertson, O.Boudker, A.Accardi. Structural Basis of pH-Dependent Activation in A Clc Transporter. Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
PubMed: 38279055
DOI: 10.1038/S41594-023-01210-5