Chlorine in PDB 8ga5: Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Intermediate

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Intermediate (pdb code 8ga5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Intermediate, PDB code: 8ga5:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in 8ga5

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Chlorine binding site 1 out of 6 in the Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Intermediate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Intermediate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl501

b:35.2
occ:1.00
 N A:PHE357 2.9 31.4 1.0
N A:ALA358 3.2 29.8 1.0
C A:GLY355 3.3 25.5 1.0
CA A:GLY146 3.4 28.0 1.0
CB A:GLU148 3.4 30.6 1.0
CB A:PHE357 3.4 31.4 1.0
CA A:GLY355 3.4 25.5 1.0
N A:ILE356 3.5 28.1 1.0
C A:GLY146 3.5 28.0 1.0
CA A:PHE357 3.6 31.4 1.0
N A:GLU148 3.6 30.6 1.0
O A:GLY355 3.6 25.5 1.0
O A:GLY146 3.7 28.0 1.0
CL A:CL502 3.8 27.6 1.0
N A:GLY149 3.8 26.2 1.0
N A:GLY146 3.8 28.0 1.0
O A:HOH611 3.8 33.2 1.0
C A:ILE356 3.9 28.1 1.0
C A:PHE357 3.9 31.4 1.0
CA A:GLU148 4.0 30.6 1.0
N A:GLY355 4.1 25.5 1.0
OE1 A:GLU148 4.1 30.6 1.0
N A:ARG147 4.1 29.6 1.0
CB A:ALA358 4.2 29.8 1.0
CA A:ILE356 4.2 28.1 1.0
CD A:PRO359 4.3 28.3 1.0
CA A:ALA358 4.3 29.8 1.0
C A:GLU148 4.4 30.6 1.0
CG A:GLU148 4.5 30.6 1.0
C A:ARG147 4.7 29.6 1.0
CD A:GLU148 4.8 30.6 1.0
CA A:GLY149 4.8 26.2 1.0
CG A:PHE357 4.8 31.4 1.0
O A:ILE356 4.8 28.1 1.0
CA A:ARG147 5.0 29.6 1.0

Chlorine binding site 2 out of 6 in 8ga5

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Chlorine binding site 2 out of 6 in the Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Intermediate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Intermediate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl502

b:27.6
occ:1.00
 OH A:TYR445 2.4 27.4 1.0
OG A:SER107 2.5 24.4 1.0
OE1 A:GLU148 3.1 30.6 1.0
N A:ILE356 3.3 28.1 1.0
CZ A:TYR445 3.4 27.4 1.0
CA A:GLY355 3.4 25.5 1.0
CB A:SER107 3.5 24.4 1.0
N A:PHE357 3.7 31.4 1.0
CE1 A:TYR445 3.8 27.4 1.0
CA A:GLY149 3.8 26.2 1.0
CL A:CL501 3.8 35.2 1.0
C A:GLY355 3.9 25.5 1.0
N A:GLY149 3.9 26.2 1.0
CB A:PHE357 3.9 31.4 1.0
CD1 A:ILE109 4.0 26.9 1.0
CD A:GLU148 4.3 30.6 1.0
CA A:ILE356 4.3 28.1 1.0
CG1 A:ILE109 4.3 26.9 1.0
CA A:PHE357 4.4 31.4 1.0
C A:ILE356 4.4 28.1 1.0
CG2 A:ILE356 4.5 28.1 1.0
CA A:SER107 4.5 24.4 1.0
CE2 A:TYR445 4.5 27.4 1.0
N A:GLY355 4.7 25.5 1.0
CD1 A:PHE357 4.9 31.4 1.0
CG A:PHE357 4.9 31.4 1.0
CB A:ILE356 4.9 28.1 1.0
C A:GLU148 4.9 30.6 1.0
CB A:GLU148 4.9 30.6 1.0

Chlorine binding site 3 out of 6 in 8ga5

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Chlorine binding site 3 out of 6 in the Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Intermediate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Intermediate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl503

b:28.9
occ:1.00
 O A:HOH614 2.8 25.5 1.0
N A:SER107 2.9 24.4 1.0
CA A:GLY106 3.6 23.6 1.0
CG2 A:ILE448 3.7 29.0 1.0
CZ A:PHE348 3.7 25.8 1.0
CB A:SER107 3.7 24.4 1.0
C A:GLY106 3.8 23.6 1.0
CA A:SER107 3.8 24.4 1.0
CD A:PRO110 4.0 27.8 1.0
CG A:PRO110 4.1 27.8 1.0
CD1 A:ILE448 4.1 29.0 1.0
N A:GLY108 4.1 25.0 1.0
CE1 A:PHE348 4.1 25.8 1.0
O A:GLY105 4.3 24.8 1.0
O A:HOH606 4.5 24.2 1.0
C A:SER107 4.5 24.4 1.0
O A:HOH608 4.6 23.5 1.0
CE2 A:PHE348 4.6 25.8 1.0
O A:HOH607 4.6 22.9 1.0
CB A:ILE448 4.7 29.0 1.0
CB A:PRO110 4.8 27.8 1.0
N A:GLY106 4.8 23.6 1.0
CG1 A:ILE448 4.8 29.0 1.0
O A:GLY106 4.9 23.6 1.0
OG A:SER107 5.0 24.4 1.0

Chlorine binding site 4 out of 6 in 8ga5

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Chlorine binding site 4 out of 6 in the Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Intermediate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Intermediate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl501

b:36.1
occ:1.00
 N B:GLU148 3.2 31.1 1.0
N B:PHE357 3.3 30.8 1.0
CA B:GLY146 3.4 27.8 1.0
CB B:GLU148 3.4 31.1 1.0
CB B:PHE357 3.4 30.8 1.0
CA B:GLY355 3.4 27.5 1.0
C B:GLY146 3.4 27.8 1.0
C B:GLY355 3.5 27.5 1.0
CL B:CL502 3.6 33.2 1.0
N B:ARG147 3.6 30.5 1.0
N B:ALA358 3.6 28.6 1.0
N B:ILE356 3.7 28.4 1.0
N B:GLY149 3.7 26.4 1.0
CA B:GLU148 3.8 31.1 1.0
CA B:PHE357 3.8 30.8 1.0
O B:GLY146 4.0 27.8 1.0
N B:GLY146 4.0 27.8 1.0
CD2 B:PHE357 4.0 30.8 1.0
O B:GLY355 4.0 27.5 1.0
N B:GLY355 4.1 27.5 1.0
CG B:PHE357 4.2 30.8 1.0
C B:ARG147 4.2 30.5 1.0
C B:PHE357 4.2 30.8 1.0
C B:ILE356 4.2 28.4 1.0
C B:GLU148 4.3 31.1 1.0
CA B:ARG147 4.4 30.5 1.0
CA B:ILE356 4.5 28.4 1.0
CB B:ALA358 4.6 28.6 1.0
OE2 B:GLU148 4.6 31.1 1.0
CA B:ALA358 4.7 28.6 1.0
CA B:GLY149 4.8 26.4 1.0
CG B:GLU148 4.8 31.1 1.0
CD B:PRO359 4.9 26.8 1.0

Chlorine binding site 5 out of 6 in 8ga5

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Chlorine binding site 5 out of 6 in the Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Intermediate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Intermediate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl502

b:33.2
occ:1.00
 OH B:TYR445 2.5 26.8 1.0
OG B:SER107 2.5 25.6 1.0
N B:ILE356 3.4 28.4 1.0
CZ B:TYR445 3.4 26.8 1.0
CA B:GLY355 3.5 27.5 1.0
CL B:CL501 3.6 36.1 1.0
CB B:SER107 3.7 25.6 1.0
N B:GLY149 3.7 26.4 1.0
CD1 B:ILE109 3.8 26.9 1.0
CE1 B:TYR445 3.8 26.8 1.0
N B:PHE357 3.8 30.8 1.0
CA B:GLY149 3.9 26.4 1.0
C B:GLY355 3.9 27.5 1.0
CB B:PHE357 4.1 30.8 1.0
OE2 B:GLU148 4.2 31.1 1.0
CG1 B:ILE109 4.2 26.9 1.0
CA B:ILE356 4.4 28.4 1.0
CE2 B:TYR445 4.5 26.8 1.0
CG2 B:ILE356 4.5 28.4 1.0
CA B:PHE357 4.6 30.8 1.0
CB B:GLU148 4.6 31.1 1.0
C B:ILE356 4.6 28.4 1.0
CA B:SER107 4.6 25.6 1.0
N B:GLY355 4.8 27.5 1.0
C B:GLU148 4.8 31.1 1.0
CD B:GLU148 4.8 31.1 1.0
O B:HOH603 4.9 33.8 1.0
CB B:ILE356 4.9 28.4 1.0

Chlorine binding site 6 out of 6 in 8ga5

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Chlorine binding site 6 out of 6 in the Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Intermediate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Intermediate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl503

b:33.6
occ:1.00
 N B:SER107 3.0 25.6 1.0
O B:HOH609 3.4 26.2 1.0
CA B:GLY106 3.5 25.6 1.0
CG2 B:ILE448 3.5 28.8 1.0
CZ B:PHE348 3.7 27.5 1.0
C B:GLY106 3.8 25.6 1.0
CB B:SER107 4.0 25.6 1.0
CA B:SER107 4.0 25.6 1.0
O B:HOH604 4.1 28.9 1.0
CD1 B:ILE448 4.1 28.8 1.0
CG B:PRO110 4.2 28.0 1.0
O B:GLY105 4.3 26.3 1.0
CE1 B:PHE348 4.3 27.5 1.0
CD B:PRO110 4.3 28.0 1.0
N B:GLY108 4.4 25.9 1.0
CE2 B:PHE348 4.5 27.5 1.0
CB B:ILE448 4.6 28.8 1.0
N B:GLY106 4.7 25.6 1.0
C B:SER107 4.7 25.6 1.0
CG1 B:ILE448 4.8 28.8 1.0
NE2 B:GLN277 4.8 31.4 1.0
CB B:PRO110 4.8 28.0 1.0
O B:HOH610 4.8 31.1 1.0
C B:GLY105 4.9 26.3 1.0
O B:GLY106 5.0 25.6 1.0

Reference:

E.Fortea, S.Lee, R.Chadda, Y.Argyros, P.Sandal, R.Mahoney-Kruszka, D.Ciftici, M.E.Falzone, G.Huysmans, J.L.Robertson, O.Boudker, A.Accardi. Structural Basis of pH-Dependent Activation in A Clc Transporter. Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
PubMed: 38279055
DOI: 10.1038/S41594-023-01210-5
Page generated: Tue Jul 30 09:55:15 2024

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