Chlorine in PDB 8gah: Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Twist

The binding sites of Chlorine atom in the Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Twist (pdb code 8gah). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Twist, PDB code: 8gah:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Twist


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Twist within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl501 b:27.9 occ:1.00 OG A:SER107 2.5 21.0 1.0 OH A:TYR445 2.7 25.7 1.0 N A:ILE356 3.0 21.9 1.0 CA A:GLY355 3.5 20.3 1.0 CD1 A:ILE109 3.5 24.3 1.0 CZ A:TYR445 3.5 25.7 1.0 CG2 A:ILE356 3.6 21.9 1.0 CB A:SER107 3.7 21.0 1.0 C A:GLY355 3.7 20.3 1.0 CE1 A:TYR445 3.7 25.7 1.0 CG A:GLU148 3.9 25.0 1.0 CG1 A:ILE109 4.0 24.3 1.0 CA A:ILE356 4.0 21.9 1.0 CA A:GLY149 4.0 21.9 1.0 N A:PHE357 4.0 24.9 1.0 OE2 A:GLU148 4.0 25.0 1.0 CB A:ILE356 4.1 21.9 1.0 N A:GLY149 4.2 21.9 1.0 C A:ILE356 4.4 21.9 1.0 CD A:GLU148 4.5 25.0 1.0 CA A:SER107 4.6 21.0 1.0 CE2 A:TYR445 4.7 25.7 1.0 C A:GLU148 4.8 25.0 1.0 CD1 A:PHE357 4.8 24.9 1.0 CB A:ILE109 4.8 24.3 1.0 N A:GLY355 4.8 20.3 1.0 O A:GLY355 4.9 20.3 1.0 CG A:PHE357 5.0 24.9 1.0 CD1 A:TYR445 5.0 25.7 1.0

Chlorine binding site 2 out of 4 in the Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Twist


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Twist within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl502 b:21.1 occ:1.00 N A:SER107 2.9 21.0 1.0 CZ A:PHE348 3.4 20.2 1.0 CA A:GLY106 3.5 19.3 1.0 CG2 A:ILE448 3.7 25.4 1.0 C A:GLY106 3.7 19.3 1.0 CB A:SER107 3.8 21.0 1.0 CD1 A:ILE448 3.8 25.4 1.0 CA A:SER107 3.9 21.0 1.0 CE1 A:PHE348 4.0 20.2 1.0 CE2 A:PHE348 4.2 20.2 1.0 CG A:PRO110 4.3 24.5 1.0 CD A:PRO110 4.3 24.5 1.0 N A:GLY108 4.4 22.9 1.0 O A:GLY105 4.4 18.7 1.0 CG1 A:ILE448 4.6 25.4 1.0 CB A:ILE448 4.6 25.4 1.0 NE2 A:GLN277 4.6 25.2 1.0 C A:SER107 4.7 21.0 1.0 N A:GLY106 4.7 19.3 1.0 O A:GLY106 4.9 19.3 1.0

Chlorine binding site 3 out of 4 in the Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Twist


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Twist within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl501 b:24.8 occ:1.00 OH B:TYR445 2.4 22.9 1.0 OG B:SER107 2.5 19.8 1.0 N B:ILE356 3.3 19.4 1.0 CA B:GLY355 3.4 19.2 1.0 CZ B:TYR445 3.4 22.9 1.0 CD1 B:ILE109 3.5 22.1 1.0 CB B:SER107 3.6 19.8 1.0 CG B:GLU148 3.7 23.2 1.0 C B:GLY355 3.9 19.2 1.0 CG1 B:ILE109 4.0 22.1 1.0 CE1 B:TYR445 4.0 22.9 1.0 CA B:GLY149 4.1 20.7 1.0 OE2 B:GLU148 4.1 23.2 1.0 N B:GLY149 4.1 20.7 1.0 N B:PHE357 4.2 23.1 1.0 CG2 B:ILE356 4.3 19.4 1.0 CD1 B:PHE357 4.3 23.1 1.0 CE2 B:TYR445 4.3 22.9 1.0 CA B:ILE356 4.4 19.4 1.0 CD B:GLU148 4.4 23.2 1.0 CG B:PHE357 4.5 23.1 1.0 C B:GLU148 4.5 23.2 1.0 CE1 B:PHE357 4.6 23.1 1.0 CA B:SER107 4.6 19.8 1.0 N B:GLY355 4.7 19.2 1.0 CB B:ILE356 4.7 19.4 1.0 C B:ILE356 4.7 19.4 1.0 O B:GLU148 4.8 23.2 1.0 CB B:GLU148 4.8 23.2 1.0 CD2 B:PHE357 4.9 23.1 1.0 CB B:ILE109 4.9 22.1 1.0 CZ B:PHE357 4.9 23.1 1.0 CB B:PHE357 5.0 23.1 1.0

Chlorine binding site 4 out of 4 in the Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Twist


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Clc-EC1 L25C/A450C/C85A at pH 4.5 100MM Cl Twist within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl502 b:22.6 occ:1.00 N B:SER107 3.0 19.8 1.0 CZ B:PHE348 3.5 19.1 1.0 CA B:GLY106 3.5 19.0 1.0 C B:GLY106 3.8 19.0 1.0 CG B:PRO110 3.8 22.4 1.0 CG2 B:ILE448 3.9 23.9 1.0 CD1 B:ILE448 4.0 23.9 1.0 CB B:SER107 4.0 19.8 1.0 CA B:SER107 4.1 19.8 1.0 CE1 B:PHE348 4.2 19.1 1.0 CE2 B:PHE348 4.2 19.1 1.0 O B:GLY105 4.2 20.4 1.0 CD B:PRO110 4.3 22.4 1.0 N B:GLY108 4.4 20.6 1.0 N B:GLY106 4.7 19.0 1.0 NE2 B:GLN277 4.7 22.3 1.0 C B:SER107 4.8 19.8 1.0 CB B:ILE448 4.8 23.9 1.0 CG1 B:ILE448 4.9 23.9 1.0 C B:GLY105 4.9 20.4 1.0 O B:GLY106 5.0 19.0 1.0

E.Fortea, S.Lee, R.Chadda, Y.Argyros, P.Sandal, R.Mahoney-Kruszka, D.Ciftici, M.E.Falzone, G.Huysmans, J.L.Robertson, O.Boudker, A.Accardi. Structural Basis of pH-Dependent Activation in A Clc Transporter. Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
PubMed: 38279055
DOI: 10.1038/S41594-023-01210-5