Chlorine in PDB 8hdg: Small Peptide Enhances the Binding of Nutline-3A to Mdmx

The structure of Small Peptide Enhances the Binding of Nutline-3A to Mdmx, PDB code: 8hdg was solved by X.Y.Cheng, Y.Huang, Q.Y.Wei, J.J.Huang, Y.W.Peng, Z.D.Su, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.84 / 1.73
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	47.844, 47.879, 92.233, 90, 90.05, 90
R / Rfree (%)	20.5 / 24.1

The binding sites of Chlorine atom in the Small Peptide Enhances the Binding of Nutline-3A to Mdmx (pdb code 8hdg). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 8 binding sites of Chlorine where determined in the Small Peptide Enhances the Binding of Nutline-3A to Mdmx, PDB code: 8hdg:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Chlorine binding site 1 out of 8 in the Small Peptide Enhances the Binding of Nutline-3A to Mdmx


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Small Peptide Enhances the Binding of Nutline-3A to Mdmx within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl201 b:23.0 occ:1.00 CL1 D:NUT201 0.0 23.0 1.0 C22 D:NUT201 1.7 20.3 1.0 C23 D:NUT201 2.7 20.9 1.0 C21 D:NUT201 2.7 22.5 1.0 H24 D:NUT201 2.8 20.9 1.0 H25 D:NUT201 2.8 21.8 1.0 HD13 D:ILE60 2.9 20.2 1.0 HB3 D:LEU56 3.0 19.6 1.0 HD22 D:LEU98 3.0 28.1 1.0 HD23 D:LEU98 3.0 28.1 1.0 HZ D:PHE90 3.1 28.8 1.0 HD12 D:ILE60 3.1 20.2 1.0 HD11 D:LEU98 3.3 28.8 1.0 CD1 D:ILE60 3.5 20.5 1.0 HD12 D:LEU56 3.5 21.8 1.0 CD2 D:LEU98 3.5 28.0 1.0 HD12 D:LEU98 3.7 28.8 1.0 CD1 D:LEU98 3.8 29.1 1.0 HD11 D:ILE60 3.9 20.2 1.0 CB D:LEU56 3.9 19.6 1.0 C24 D:NUT201 4.0 21.3 1.0 CZ D:PHE90 4.0 29.3 1.0 C20 D:NUT201 4.0 22.0 1.0 HB2 D:LEU56 4.0 19.6 1.0 HD22 D:LEU56 4.0 21.3 1.0 HE2 D:PHE90 4.2 28.8 1.0 HD21 D:LEU98 4.3 28.1 1.0 CG D:LEU98 4.3 28.2 1.0 CD1 D:LEU56 4.4 22.3 1.0 HD23 D:LEU81 4.4 17.7 1.0 C19 D:NUT201 4.5 19.4 1.0 CE2 D:PHE90 4.5 29.4 1.0 C D:LEU56 4.5 18.0 1.0 HE2 D:MET53 4.6 24.4 1.0 CG D:LEU56 4.6 20.6 1.0 HA2 D:GLY57 4.6 20.1 1.0 O D:LEU56 4.6 18.4 1.0 HE3 D:MET53 4.7 24.4 1.0 HG13 D:ILE60 4.7 19.3 1.0 H23 D:NUT201 4.7 20.8 1.0 CG1 D:ILE60 4.7 19.5 1.0 H26 D:NUT201 4.7 21.5 1.0 HD13 D:LEU98 4.7 28.8 1.0 CD2 D:LEU56 4.8 21.6 1.0 N D:GLY57 4.8 18.9 1.0 HD13 D:LEU56 4.8 21.8 1.0 HD11 D:LEU81 4.8 19.8 1.0 CA D:LEU56 4.9 18.8 1.0 HB2 D:LEU98 4.9 24.4 1.0 HD11 D:LEU56 5.0 21.8 1.0 HG D:LEU98 5.0 27.4 1.0 CE1 D:PHE90 5.0 28.5 1.0

Chlorine binding site 2 out of 8 in the Small Peptide Enhances the Binding of Nutline-3A to Mdmx


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Small Peptide Enhances the Binding of Nutline-3A to Mdmx within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl201 b:28.6 occ:1.00 CL D:NUT201 0.0 28.6 1.0 C15 D:NUT201 1.7 23.9 1.0 C14 D:NUT201 2.7 22.5 1.0 C16 D:NUT201 2.7 26.8 1.0 H32 D:NUT201 2.8 22.8 1.0 H31 D:NUT201 2.8 25.3 1.0 HD21 D:LEU98 2.8 28.1 1.0 HB2 D:PRO95 3.1 27.9 1.0 HE1 D:TYR99 3.2 23.7 1.0 HE1 D:MET53 3.5 24.4 1.0 CE1 D:TYR99 3.7 24.6 1.0 HB3 D:PRO95 3.7 27.9 1.0 CB D:PRO95 3.7 28.7 1.0 CD2 D:LEU98 3.8 28.0 1.0 HG3 D:PRO95 3.9 27.4 1.0 HD23 D:LEU98 3.9 28.1 1.0 HE3 D:MET53 3.9 24.4 1.0 C13 D:NUT201 4.0 21.7 1.0 C17 D:NUT201 4.0 24.3 1.0 HG D:LEU98 4.1 27.4 1.0 CE D:MET53 4.1 23.6 1.0 CG D:PRO95 4.2 27.4 1.0 HG2 D:PRO95 4.2 27.4 1.0 HB3 D:LEU98 4.2 24.4 1.0 HD1 D:TYR99 4.2 21.9 1.0 CD1 D:TYR99 4.3 21.1 1.0 CZ D:TYR99 4.4 24.7 1.0 HD22 D:LEU98 4.4 28.1 1.0 CG D:LEU98 4.5 28.2 1.0 OH D:TYR99 4.5 27.7 1.0 C12 D:NUT201 4.5 22.4 1.0 HE2 D:MET53 4.7 24.4 1.0 H33 D:NUT201 4.7 22.2 1.0 H30 D:NUT201 4.7 24.3 1.0 CB D:LEU98 4.9 23.9 1.0

Chlorine binding site 3 out of 8 in the Small Peptide Enhances the Binding of Nutline-3A to Mdmx


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Small Peptide Enhances the Binding of Nutline-3A to Mdmx within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl201 b:23.4 occ:1.00 CL1 A:NUT201 0.0 23.4 1.0 C22 A:NUT201 1.7 20.1 1.0 C23 A:NUT201 2.7 21.7 1.0 C21 A:NUT201 2.7 21.4 1.0 H24 A:NUT201 2.8 21.1 1.0 H25 A:NUT201 2.8 20.9 1.0 HD22 A:LEU98 2.9 27.8 1.0 HD13 A:ILE60 2.9 20.3 1.0 HB3 A:LEU56 3.0 19.1 1.0 HD23 A:LEU98 3.0 27.8 1.0 HZ A:PHE90 3.1 27.4 1.0 HD12 A:ILE60 3.2 20.3 1.0 HD11 A:LEU98 3.2 30.1 1.0 CD2 A:LEU98 3.4 27.6 1.0 CD1 A:ILE60 3.5 20.4 1.0 HD12 A:LEU56 3.5 21.1 1.0 HD12 A:LEU98 3.7 30.1 1.0 CD1 A:LEU98 3.8 31.0 1.0 HD11 A:ILE60 3.9 20.3 1.0 CB A:LEU56 3.9 19.1 1.0 CZ A:PHE90 4.0 27.3 1.0 C24 A:NUT201 4.0 20.7 1.0 C20 A:NUT201 4.0 20.6 1.0 HB2 A:LEU56 4.0 19.1 1.0 HD22 A:LEU56 4.1 22.4 1.0 HD21 A:LEU98 4.2 27.8 1.0 CG A:LEU98 4.3 28.3 1.0 HE2 A:MET53 4.3 24.3 1.0 HE2 A:PHE90 4.3 27.2 1.0 CD1 A:LEU56 4.4 21.1 1.0 HD23 A:LEU81 4.5 19.6 1.0 C19 A:NUT201 4.5 19.6 1.0 CE2 A:PHE90 4.5 27.1 1.0 C A:LEU56 4.6 17.8 1.0 HA2 A:GLY57 4.6 19.8 1.0 CG A:LEU56 4.6 21.0 1.0 O A:LEU56 4.7 18.3 1.0 HG13 A:ILE60 4.7 19.7 1.0 H23 A:NUT201 4.7 20.7 1.0 HD13 A:LEU98 4.7 30.1 1.0 H26 A:NUT201 4.7 20.7 1.0 CG1 A:ILE60 4.7 19.9 1.0 HD11 A:LEU81 4.8 20.7 1.0 CD2 A:LEU56 4.8 23.0 1.0 N A:GLY57 4.8 18.5 1.0 HD13 A:LEU56 4.8 21.1 1.0 CA A:LEU56 4.9 17.4 1.0 HB2 A:LEU98 4.9 25.0 1.0 HG A:LEU98 4.9 27.9 1.0 CE1 A:PHE90 5.0 29.0 1.0 HE1 A:PHE90 5.0 27.3 1.0 HD11 A:LEU56 5.0 21.1 1.0

Chlorine binding site 4 out of 8 in the Small Peptide Enhances the Binding of Nutline-3A to Mdmx


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Small Peptide Enhances the Binding of Nutline-3A to Mdmx within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl201 b:26.7 occ:1.00 CL A:NUT201 0.0 26.7 1.0 C15 A:NUT201 1.7 24.6 1.0 C14 A:NUT201 2.7 22.9 1.0 C16 A:NUT201 2.7 26.2 1.0 H32 A:NUT201 2.8 23.4 1.0 H31 A:NUT201 2.8 25.1 1.0 HD21 A:LEU98 2.9 27.8 1.0 HB2 A:PRO95 3.1 28.5 1.0 HE1 A:TYR99 3.3 25.3 1.0 HE3 A:MET53 3.5 24.3 1.0 HB3 A:PRO95 3.7 28.5 1.0 CE1 A:TYR99 3.7 26.3 1.0 CB A:PRO95 3.7 29.2 1.0 CD2 A:LEU98 3.8 27.6 1.0 HG3 A:PRO95 3.9 28.1 1.0 HE1 A:MET53 3.9 24.3 1.0 C13 A:NUT201 4.0 22.9 1.0 HD23 A:LEU98 4.0 27.8 1.0 C17 A:NUT201 4.0 23.9 1.0 HG A:LEU98 4.2 27.9 1.0 CG A:PRO95 4.2 27.6 1.0 CE A:MET53 4.2 23.6 1.0 HG2 A:PRO95 4.2 28.1 1.0 HB3 A:LEU98 4.2 25.0 1.0 HD1 A:TYR99 4.3 23.8 1.0 CD1 A:TYR99 4.3 23.2 1.0 CZ A:TYR99 4.3 25.3 1.0 OH A:TYR99 4.5 28.0 1.0 HD22 A:LEU98 4.5 27.8 1.0 C12 A:NUT201 4.5 23.2 1.0 CG A:LEU98 4.5 28.3 1.0 H33 A:NUT201 4.7 23.1 1.0 H30 A:NUT201 4.7 24.2 1.0 HE2 A:MET53 4.8 24.3 1.0 CB A:LEU98 4.9 24.5 1.0

Chlorine binding site 5 out of 8 in the Small Peptide Enhances the Binding of Nutline-3A to Mdmx


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Small Peptide Enhances the Binding of Nutline-3A to Mdmx within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl201 b:23.1 occ:1.00 CL1 C:NUT201 0.0 23.1 1.0 C22 C:NUT201 1.7 19.7 1.0 C23 C:NUT201 2.7 20.5 1.0 C21 C:NUT201 2.7 21.6 1.0 H24 C:NUT201 2.8 20.6 1.0 H25 C:NUT201 2.8 21.4 1.0 HD13 C:ILE60 2.9 20.1 1.0 HD22 C:LEU98 3.0 27.7 1.0 HB3 C:LEU56 3.0 18.2 1.0 HD23 C:LEU98 3.0 27.7 1.0 HZ C:PHE90 3.1 27.2 1.0 HD12 C:ILE60 3.2 20.1 1.0 HD11 C:LEU98 3.2 29.2 1.0 CD2 C:LEU98 3.4 27.6 1.0 HD12 C:LEU56 3.5 20.3 1.0 CD1 C:ILE60 3.5 20.5 1.0 HD12 C:LEU98 3.7 29.2 1.0 CD1 C:LEU98 3.8 29.8 1.0 CB C:LEU56 3.9 18.0 1.0 HD11 C:ILE60 3.9 20.1 1.0 C24 C:NUT201 4.0 21.5 1.0 C20 C:NUT201 4.0 22.7 1.0 CZ C:PHE90 4.0 27.7 1.0 HB2 C:LEU56 4.0 18.2 1.0 HD22 C:LEU56 4.1 20.2 1.0 HD21 C:LEU98 4.2 27.7 1.0 HE2 C:PHE90 4.2 27.3 1.0 CG C:LEU98 4.3 27.9 1.0 CD1 C:LEU56 4.4 20.8 1.0 HD23 C:LEU81 4.4 18.3 1.0 C19 C:NUT201 4.5 20.6 1.0 CE2 C:PHE90 4.5 27.7 1.0 HE2 C:MET53 4.6 23.8 1.0 C C:LEU56 4.6 17.0 1.0 CG C:LEU56 4.6 19.3 1.0 HA2 C:GLY57 4.6 19.2 1.0 HE3 C:MET53 4.6 23.8 1.0 O C:LEU56 4.7 18.0 1.0 H23 C:NUT201 4.7 21.1 1.0 HG13 C:ILE60 4.7 19.3 1.0 H26 C:NUT201 4.7 21.9 1.0 HD13 C:LEU98 4.7 29.1 1.0 CG1 C:ILE60 4.7 19.4 1.0 N C:GLY57 4.8 17.9 1.0 CD2 C:LEU56 4.8 20.7 1.0 HD13 C:LEU56 4.8 20.3 1.0 HD11 C:LEU81 4.8 19.1 1.0 CA C:LEU56 4.9 17.4 1.0 HB2 C:LEU98 4.9 24.4 1.0 HG C:LEU98 4.9 27.3 1.0 HD11 C:LEU56 5.0 20.3 1.0 CE1 C:PHE90 5.0 26.5 1.0

Chlorine binding site 6 out of 8 in the Small Peptide Enhances the Binding of Nutline-3A to Mdmx


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Small Peptide Enhances the Binding of Nutline-3A to Mdmx within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl201 b:28.2 occ:1.00 CL C:NUT201 0.0 28.2 1.0 C15 C:NUT201 1.7 24.1 1.0 C14 C:NUT201 2.7 23.0 1.0 C16 C:NUT201 2.7 25.8 1.0 H32 C:NUT201 2.8 23.2 1.0 H31 C:NUT201 2.8 24.7 1.0 HD21 C:LEU98 2.9 27.7 1.0 HB2 C:PRO95 3.0 29.7 1.0 HE1 C:TYR99 3.2 24.5 1.0 HE1 C:MET53 3.5 23.8 1.0 HB3 C:PRO95 3.6 29.7 1.0 CE1 C:TYR99 3.7 25.3 1.0 CB C:PRO95 3.7 30.9 1.0 CD2 C:LEU98 3.8 27.6 1.0 HG3 C:PRO95 3.9 29.3 1.0 HD23 C:LEU98 3.9 27.7 1.0 HE3 C:MET53 4.0 23.8 1.0 C13 C:NUT201 4.0 22.6 1.0 C17 C:NUT201 4.0 23.4 1.0 HG C:LEU98 4.1 27.3 1.0 CG C:PRO95 4.1 28.9 1.0 CE C:MET53 4.2 23.0 1.0 HG2 C:PRO95 4.2 29.3 1.0 HB3 C:LEU98 4.2 24.4 1.0 HD1 C:TYR99 4.2 22.7 1.0 CD1 C:TYR99 4.3 21.5 1.0 CZ C:TYR99 4.3 26.0 1.0 HD22 C:LEU98 4.4 27.7 1.0 CG C:LEU98 4.5 27.9 1.0 C12 C:NUT201 4.5 22.6 1.0 OH C:TYR99 4.5 27.7 1.0 HE2 C:MET53 4.7 23.8 1.0 H33 C:NUT201 4.7 22.9 1.0 H30 C:NUT201 4.7 23.8 1.0 CB C:LEU98 4.9 23.7 1.0 O C:PRO95 5.0 24.5 1.0

Chlorine binding site 7 out of 8 in the Small Peptide Enhances the Binding of Nutline-3A to Mdmx


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Small Peptide Enhances the Binding of Nutline-3A to Mdmx within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl201 b:22.2 occ:1.00 CL1 B:NUT201 0.0 22.2 1.0 C22 B:NUT201 1.7 19.4 1.0 C23 B:NUT201 2.7 22.8 1.0 C21 B:NUT201 2.7 20.5 1.0 H24 B:NUT201 2.8 21.7 1.0 H25 B:NUT201 2.8 20.3 1.0 HD13 B:ILE60 2.9 21.1 1.0 HD22 B:LEU98 2.9 27.4 1.0 HB3 B:LEU56 3.0 18.2 1.0 HD23 B:LEU98 3.1 27.4 1.0 HZ B:PHE90 3.1 28.8 1.0 HD11 B:LEU98 3.2 29.8 1.0 HD12 B:ILE60 3.2 21.1 1.0 CD2 B:LEU98 3.4 27.0 1.0 HD12 B:LEU56 3.5 19.5 1.0 CD1 B:ILE60 3.5 21.7 1.0 HD12 B:LEU98 3.7 29.8 1.0 CD1 B:LEU98 3.8 30.6 1.0 HD11 B:ILE60 3.9 21.1 1.0 CB B:LEU56 3.9 18.1 1.0 C24 B:NUT201 4.0 21.9 1.0 C20 B:NUT201 4.0 20.2 1.0 CZ B:PHE90 4.0 30.0 1.0 HB2 B:LEU56 4.0 18.2 1.0 HD22 B:LEU56 4.1 20.9 1.0 HD21 B:LEU98 4.2 27.4 1.0 HE2 B:PHE90 4.2 28.4 1.0 HE2 B:MET53 4.3 23.5 1.0 CG B:LEU98 4.3 28.2 1.0 CD1 B:LEU56 4.4 19.5 1.0 HD23 B:LEU81 4.4 18.1 1.0 C19 B:NUT201 4.5 20.0 1.0 CE2 B:PHE90 4.5 28.2 1.0 C B:LEU56 4.6 16.9 1.0 CG B:LEU56 4.6 19.6 1.0 HA2 B:GLY57 4.6 19.1 1.0 O B:LEU56 4.6 16.9 1.0 HG13 B:ILE60 4.7 20.0 1.0 H23 B:NUT201 4.7 21.6 1.0 HD13 B:LEU98 4.7 29.7 1.0 H26 B:NUT201 4.7 20.3 1.0 CG1 B:ILE60 4.7 20.1 1.0 N B:GLY57 4.8 17.9 1.0 CD2 B:LEU56 4.8 21.6 1.0 HD13 B:LEU56 4.8 19.5 1.0 HD11 B:LEU81 4.8 19.3 1.0 CA B:LEU56 4.9 16.9 1.0 HB2 B:LEU98 4.9 24.2 1.0 HG B:LEU98 5.0 27.4 1.0 HD11 B:LEU56 5.0 19.5 1.0 CE1 B:PHE90 5.0 28.3 1.0

Chlorine binding site 8 out of 8 in the Small Peptide Enhances the Binding of Nutline-3A to Mdmx


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Small Peptide Enhances the Binding of Nutline-3A to Mdmx within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl201 b:27.2 occ:1.00 CL B:NUT201 0.0 27.2 1.0 C15 B:NUT201 1.7 26.3 1.0 C14 B:NUT201 2.7 22.7 1.0 C16 B:NUT201 2.7 27.7 1.0 H32 B:NUT201 2.8 23.5 1.0 H31 B:NUT201 2.8 26.4 1.0 HB2 C:LEU14 2.9 26.7 1.0 HD21 B:LEU98 2.9 27.4 1.0 HB2 B:PRO95 3.1 29.8 1.0 HE1 B:TYR99 3.2 24.1 1.0 HB3 C:LEU14 3.5 26.7 1.0 HD13 C:LEU14 3.5 26.8 1.0 HE3 B:MET53 3.5 23.5 1.0 CB C:LEU14 3.6 26.1 1.0 CE1 B:TYR99 3.7 25.0 1.0 HB3 B:PRO95 3.7 29.9 1.0 CB B:PRO95 3.7 30.8 1.0 CD2 B:LEU98 3.8 27.0 1.0 O B:HOH326 3.8 41.9 1.0 HD23 B:LEU98 3.9 27.4 1.0 HG3 B:PRO95 3.9 29.6 1.0 HE1 B:MET53 3.9 23.5 1.0 C13 B:NUT201 4.0 22.2 1.0 C17 B:NUT201 4.0 24.9 1.0 HG B:LEU98 4.1 27.4 1.0 CE B:MET53 4.2 22.5 1.0 H C:GLU15 4.2 25.0 1.0 CG B:PRO95 4.2 29.2 1.0 CD1 C:LEU14 4.2 26.4 1.0 HG2 B:PRO95 4.2 29.6 1.0 HB3 B:LEU98 4.2 24.2 1.0 HD1 B:TYR99 4.3 22.6 1.0 CD1 B:TYR99 4.3 21.4 1.0 HD12 C:LEU14 4.3 26.8 1.0 N C:GLU15 4.3 25.3 1.0 CZ B:TYR99 4.3 25.0 1.0 OH B:TYR99 4.4 26.9 1.0 HD22 B:LEU98 4.5 27.4 1.0 CG B:LEU98 4.5 28.2 1.0 C C:LEU14 4.5 22.5 1.0 C12 B:NUT201 4.5 23.4 1.0 HA C:GLU15 4.5 27.7 1.0 CG C:LEU14 4.5 27.7 1.0 CA C:LEU14 4.7 27.1 1.0 H33 B:NUT201 4.7 22.8 1.0 HE2 B:MET53 4.7 23.5 1.0 H30 B:NUT201 4.7 25.1 1.0 CA C:GLU15 4.8 27.1 1.0 CB B:LEU98 4.9 23.3 1.0 HG C:LEU14 5.0 27.4 1.0 CB C:GLU15 5.0 31.8 1.0 O C:LEU14 5.0 24.7 1.0

X.Y.Cheng, Y.Huang, Q.Y.Wei, J.J.Huang, Y.W.Peng, Z.D.Su. Small Peptide Enhances the Binding of Nutline-3A to Mdmx To Be Published.