Chlorine in PDB 8hum: X-Ray Structure of Human Ppar Gamma Ligand Binding Domain- Lanifibranor-SRC1 Coactivator Peptide Co-Crystals Obtained By Co- Crystallization

Enzymatic activity of X-Ray Structure of Human Ppar Gamma Ligand Binding Domain- Lanifibranor-SRC1 Coactivator Peptide Co-Crystals Obtained By Co- Crystallization

All present enzymatic activity of X-Ray Structure of Human Ppar Gamma Ligand Binding Domain- Lanifibranor-SRC1 Coactivator Peptide Co-Crystals Obtained By Co- Crystallization:
2.3.1.48;

Protein crystallography data

The structure of X-Ray Structure of Human Ppar Gamma Ligand Binding Domain- Lanifibranor-SRC1 Coactivator Peptide Co-Crystals Obtained By Co- Crystallization, PDB code: 8hum was solved by S.Kamata, A.Honda, Y.Machida, K.Uchii, Y.Shiiyama, R.Masuda, T.Oyama, I.Ishii, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.27 / 2.29
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 49.862, 63.728, 123.484, 90, 90, 90
R / Rfree (%) 20.6 / 25

Chlorine Binding Sites:

The binding sites of Chlorine atom in the X-Ray Structure of Human Ppar Gamma Ligand Binding Domain- Lanifibranor-SRC1 Coactivator Peptide Co-Crystals Obtained By Co- Crystallization (pdb code 8hum). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the X-Ray Structure of Human Ppar Gamma Ligand Binding Domain- Lanifibranor-SRC1 Coactivator Peptide Co-Crystals Obtained By Co- Crystallization, PDB code: 8hum:

Chlorine binding site 1 out of 1 in 8hum

Go back to Chlorine Binding Sites List in 8hum
Chlorine binding site 1 out of 1 in the X-Ray Structure of Human Ppar Gamma Ligand Binding Domain- Lanifibranor-SRC1 Coactivator Peptide Co-Crystals Obtained By Co- Crystallization


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of Human Ppar Gamma Ligand Binding Domain- Lanifibranor-SRC1 Coactivator Peptide Co-Crystals Obtained By Co- Crystallization within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl501

b:60.8
occ:1.00
 CL1 A:BJB501 0.0 60.8 1.0
C7 A:BJB501 1.8 58.2 1.0
C8 A:BJB501 2.8 57.3 1.0
H1 A:BJB501 2.9 68.8 1.0
C6 A:BJB501 2.9 57.7 1.0
H9 A:BJB501 3.0 69.3 1.0
CD1 A:LEU356 3.6 51.0 1.0
CG2 A:ILE281 3.6 55.8 1.0
O A:PHE360 3.7 57.0 1.0
CB A:PHE360 4.0 53.4 1.0
C9 A:BJB501 4.2 60.4 1.0
C A:PHE360 4.3 57.9 1.0
CD1 A:PHE360 4.3 62.1 1.0
C4 A:BJB501 4.3 59.9 1.0
CD1 A:LEU353 4.4 50.3 1.0
CA A:PHE360 4.4 59.7 1.0
CB A:ILE281 4.4 51.2 1.0
O A:ALA278 4.5 55.8 1.0
CB A:PHE363 4.5 51.7 1.0
CG A:PHE360 4.6 64.5 1.0
N A:PHE282 4.7 50.6 1.0
CD2 A:PHE363 4.7 61.2 1.0
C5 A:BJB501 4.8 63.3 1.0
H2 A:BJB501 4.9 72.5 1.0
CG A:LEU356 4.9 53.1 1.0

Reference:

S.Kamata, A.Honda, R.Ishikawa, M.Akahane, A.Fujita, C.Kaneko, S.Miyawaki, Y.Habu, Y.Shiiyama, K.Uchii, Y.Machida, T.Oyama, I.Ishii. Functional and Structural Insights Into the Human Ppar Alpha / Delta / Gamma Targeting Preferences of Anti-Nash Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor Antioxidants V. 12 1523 2023.
ISSN: ESSN 2076-3921
DOI: 10.3390/ANTIOX12081523
Page generated: Tue Jul 30 10:23:10 2024

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