Chlorine in PDB 8izi: Crystal Structure of Trypsin-Cimetidine Complex at 2.10 Angstroms Resolution

Enzymatic activity of Crystal Structure of Trypsin-Cimetidine Complex at 2.10 Angstroms Resolution

All present enzymatic activity of Crystal Structure of Trypsin-Cimetidine Complex at 2.10 Angstroms Resolution:
3.4.21.4;

Protein crystallography data

The structure of Crystal Structure of Trypsin-Cimetidine Complex at 2.10 Angstroms Resolution, PDB code: 8izi was solved by M.S.Ahmad, N.Kalam, Z.Akbar, S.Rasheed, M.I.Choudhary, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 18.65 / 2.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 54.499, 58.265, 66.547, 90, 90, 90
R / Rfree (%) 16 / 22.1

Other elements in 8izi:

The structure of Crystal Structure of Trypsin-Cimetidine Complex at 2.10 Angstroms Resolution also contains other interesting chemical elements:

Calcium (Ca) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Trypsin-Cimetidine Complex at 2.10 Angstroms Resolution (pdb code 8izi). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Trypsin-Cimetidine Complex at 2.10 Angstroms Resolution, PDB code: 8izi:

Chlorine binding site 1 out of 1 in 8izi

Go back to Chlorine Binding Sites List in 8izi
Chlorine binding site 1 out of 1 in the Crystal Structure of Trypsin-Cimetidine Complex at 2.10 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Trypsin-Cimetidine Complex at 2.10 Angstroms Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl303

b:40.2
occ:1.00
 N A:SER166 3.2 10.6 1.0
CB A:SER166 3.4 10.8 1.0
OG A:SER166 3.5 11.5 1.0
CB A:ASP165 3.8 18.6 1.0
N A:ASP165 3.8 13.1 1.0
CA A:SER166 3.9 10.8 1.0
CB A:SER164 4.1 9.8 1.0
C A:ASP165 4.1 12.1 1.0
CA A:ASP165 4.1 14.9 1.0
C A:SER164 4.5 11.4 1.0
OG A:SER164 4.6 9.0 1.0
O A:HOH436 4.7 23.6 1.0
CA A:SER164 4.7 10.3 1.0

Reference:

M.S.Ahmad, N.Kalam, Z.Akbar, N.Shah, S.Rasheed, M.I.Choudhary. Structural Basis For the Binding of Famotidine, Cimetidine, Guanidine, and Pimagedine with Serine Protease. Biochem.Biophys.Res.Commun. V. 733 50603 2024.
ISSN: ESSN 1090-2104
PubMed: 39216203
DOI: 10.1016/J.BBRC.2024.150603
Page generated: Sat Sep 28 19:24:23 2024

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