Chlorine in PDB 8j20: Cryo-Em Structure of FFAR3 Bound with Valeric Acid and AR420626

The binding sites of Chlorine atom in the Cryo-Em Structure of FFAR3 Bound with Valeric Acid and AR420626 (pdb code 8j20). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Cryo-Em Structure of FFAR3 Bound with Valeric Acid and AR420626, PDB code: 8j20:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Cryo-Em Structure of FFAR3 Bound with Valeric Acid and AR420626


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of FFAR3 Bound with Valeric Acid and AR420626 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl401 b:44.5 occ:1.00 CL01 D:9T4401 0.0 44.5 1.0 C24 D:9T4401 1.8 44.5 1.0 C23 D:9T4401 2.9 44.5 1.0 C27 D:9T4401 2.9 44.5 1.0 O D:VAL227 2.9 58.6 1.0 N07 D:9T4401 3.2 44.5 1.0 OG1 D:THR230 3.2 66.0 1.0 CD2 D:TYR204 3.3 52.7 1.0 N D:LEU231 3.5 59.4 1.0 CB D:LEU231 3.6 54.2 1.0 CG1 D:VAL227 3.7 63.2 1.0 CE2 D:TYR204 3.8 55.8 1.0 CA D:LEU231 3.8 49.7 1.0 C D:VAL227 3.8 58.9 1.0 CA D:VAL227 4.1 57.2 1.0 C D:THR230 4.1 63.9 1.0 CB D:THR230 4.2 62.7 1.0 C25 D:9T4401 4.3 44.5 1.0 C28 D:9T4401 4.3 44.5 1.0 C18 D:9T4401 4.3 44.5 1.0 CG D:LEU231 4.3 54.5 1.0 CG D:TYR204 4.4 37.8 1.0 CB D:VAL227 4.4 59.0 1.0 C20 D:9T4401 4.6 44.5 1.0 CA D:THR230 4.7 55.6 1.0 CB D:TYR204 4.7 42.3 1.0 O D:THR230 4.8 66.0 1.0 CG2 D:VAL227 4.8 57.8 1.0 C26 D:9T4401 4.8 44.5 1.0 O05 D:9T4401 4.9 44.5 1.0 CD1 D:LEU231 4.9 57.8 1.0

Chlorine binding site 2 out of 2 in the Cryo-Em Structure of FFAR3 Bound with Valeric Acid and AR420626


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of FFAR3 Bound with Valeric Acid and AR420626 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl401 b:44.5 occ:1.00 CL02 D:9T4401 0.0 44.5 1.0 C26 D:9T4401 1.8 44.5 1.0 C25 D:9T4401 2.9 44.5 1.0 C28 D:9T4401 2.9 44.5 1.0 CE2 D:PHE234 3.3 52.0 1.0 CA D:LEU197 3.4 46.2 1.0 CD2 D:LEU197 3.4 48.4 1.0 CD2 D:PHE234 3.5 50.1 1.0 O D:PRO196 3.6 62.8 1.0 CZ D:PHE234 3.6 56.4 1.0 CB D:THR200 3.8 42.7 1.0 N D:LEU197 3.8 44.8 1.0 OG1 D:THR200 3.8 45.5 1.0 C D:PRO196 3.9 54.8 1.0 CG D:LEU197 4.0 48.7 1.0 CG D:PHE234 4.1 46.6 1.0 CE1 D:PHE234 4.1 56.2 1.0 O D:LEU197 4.2 52.4 1.0 CB D:LEU197 4.2 46.9 1.0 C23 D:9T4401 4.3 44.5 1.0 C D:LEU197 4.3 46.4 1.0 C27 D:9T4401 4.3 44.5 1.0 CD1 D:PHE234 4.3 52.2 1.0 CG2 D:THR200 4.3 47.9 1.0 C24 D:9T4401 4.8 44.5 1.0 CB D:PHE234 5.0 53.2 1.0 CB D:PRO196 5.0 48.9 1.0 OG D:SER201 5.0 65.2 1.0

F.Li, L.Tai, X.Sun, Z.Lv, W.Tang, T.Wang, Z.Zhao, D.Gong, S.Ma, S.Tang, Q.Gu, X.Zhu, M.Yu, X.Liu, J.Wang. Molecular Recognition and Activation Mechanism of Short-Chain Fatty Acid Receptors FFAR2/3. Cell Res. 2024.
ISSN: ISSN 1001-0602
PubMed: 38191689
DOI: 10.1038/S41422-023-00914-Z