Chlorine in PDB 8jev: Cryo-Em Structure of Apo State Mclc-3

The binding sites of Chlorine atom in the Cryo-Em Structure of Apo State Mclc-3 (pdb code 8jev). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Cryo-Em Structure of Apo State Mclc-3, PDB code: 8jev:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in the Cryo-Em Structure of Apo State Mclc-3


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Apo State Mclc-3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl901 b:30.0 occ:1.00 HB2 A:GLU282 1.6 36.8 1.0 H A:GLU282 1.9 36.8 1.0 HB2 A:PHE527 2.4 35.6 1.0 CB A:GLU282 2.5 36.8 1.0 N A:GLU282 2.6 36.8 1.0 H A:GLY283 2.7 33.1 1.0 OE1 A:GLU282 2.7 36.8 1.0 H A:ILE528 2.8 34.5 1.0 HA3 A:GLY280 2.9 30.8 1.0 H A:PHE527 2.9 35.6 1.0 CA A:GLU282 3.0 36.8 1.0 HB3 A:GLU282 3.0 36.8 1.0 H A:LYS281 3.2 33.1 1.0 HB A:ILE528 3.3 34.5 1.0 N A:GLY283 3.3 33.1 1.0 CB A:PHE527 3.3 35.6 1.0 N A:ILE528 3.4 34.5 1.0 N A:LYS281 3.5 33.1 1.0 CD A:GLU282 3.5 36.8 1.0 CG A:GLU282 3.5 36.8 1.0 N A:PHE527 3.6 35.6 1.0 HD2 A:PRO284 3.6 31.2 1.0 HG22 A:ILE528 3.6 34.5 1.0 C A:GLU282 3.6 36.8 1.0 HA3 A:GLY525 3.7 29.3 1.0 CA A:GLY280 3.7 30.8 1.0 C A:LYS281 3.8 33.1 1.0 HB3 A:PHE527 3.8 35.6 1.0 HA A:GLU282 3.8 36.8 1.0 CA A:PHE527 3.9 35.6 1.0 C A:GLY280 3.9 30.8 1.0 HG2 A:GLU282 3.9 36.8 1.0 H A:LEU526 3.9 32.5 1.0 CB A:ILE528 4.0 34.5 1.0 HD2 A:PHE527 4.1 35.6 1.0 C A:PHE527 4.1 35.6 1.0 CG A:PHE527 4.2 35.6 1.0 CA A:LYS281 4.2 33.1 1.0 CG2 A:ILE528 4.2 34.5 1.0 HG3 A:GLU282 4.3 36.8 1.0 HA2 A:GLY280 4.3 30.8 1.0 N A:LEU526 4.3 32.5 1.0 CA A:ILE528 4.3 34.5 1.0 HG21 A:ILE528 4.4 34.5 1.0 CD2 A:PHE527 4.4 35.6 1.0 CD A:PRO284 4.5 31.2 1.0 HA A:LYS281 4.6 33.1 1.0 CA A:GLY525 4.6 29.3 1.0 HD2 A:PRO529 4.6 32.9 1.0 CA A:GLY283 4.6 33.1 1.0 H A:GLY280 4.6 30.8 1.0 OE2 A:GLU282 4.6 36.8 1.0 HD3 A:PRO284 4.7 31.2 1.0 N A:GLY280 4.7 30.8 1.0 HA3 A:GLY283 4.7 33.1 1.0 HD3 A:PRO529 4.7 32.9 1.0 C A:GLY525 4.7 29.3 1.0 C A:LEU526 4.7 32.5 1.0 HA A:ILE528 4.8 34.5 1.0 HA A:PHE527 4.8 35.6 1.0 O A:LYS281 4.8 33.1 1.0 O A:GLY280 4.8 30.8 1.0 O A:GLU282 4.9 36.8 1.0

Chlorine binding site 2 out of 6 in the Cryo-Em Structure of Apo State Mclc-3


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of Apo State Mclc-3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl902 b:30.0 occ:1.00 HG A:SER239 1.8 30.0 1.0 OH A:TYR630 1.9 34.2 1.0 HH A:TYR630 2.1 34.2 1.0 OG A:SER239 2.2 30.0 1.0 HA3 A:GLY283 2.3 33.1 1.0 H A:LEU526 2.7 32.5 1.0 HB2 A:SER239 3.0 30.0 1.0 HD12 A:ILE241 3.0 34.5 1.0 CZ A:TYR630 3.1 34.2 1.0 CB A:SER239 3.1 30.0 1.0 HB3 A:LEU526 3.2 32.5 1.0 CA A:GLY283 3.3 33.1 1.0 HA2 A:GLY525 3.3 29.3 1.0 HD3 A:PRO284 3.4 31.2 1.0 N A:LEU526 3.4 32.5 1.0 HE1 A:TYR630 3.5 34.2 1.0 HA2 A:GLY283 3.6 33.1 1.0 H A:GLY283 3.7 33.1 1.0 CE1 A:TYR630 3.7 34.2 1.0 HB3 A:SER239 3.8 30.0 1.0 HD11 A:ILE241 3.8 34.5 1.0 CD1 A:ILE241 3.9 34.5 1.0 H A:PHE527 3.9 35.6 1.0 N A:GLY283 4.0 33.1 1.0 CB A:LEU526 4.0 32.5 1.0 CA A:GLY525 4.0 29.3 1.0 HA A:SER239 4.0 30.0 1.0 HA3 A:GLY525 4.1 29.3 1.0 CE2 A:TYR630 4.1 34.2 1.0 C A:GLY283 4.1 33.1 1.0 CA A:LEU526 4.1 32.5 1.0 C A:GLY525 4.2 29.3 1.0 HE2 A:TYR630 4.2 34.2 1.0 CD A:PRO284 4.2 31.2 1.0 CA A:SER239 4.2 30.0 1.0 HB2 A:LEU526 4.2 32.5 1.0 HD2 A:PRO284 4.4 31.2 1.0 CE1 A:PHE527 4.4 35.6 1.0 CD1 A:PHE527 4.4 35.6 1.0 N A:PHE527 4.4 35.6 1.0 HG13 A:ILE241 4.4 34.5 1.0 N A:PRO284 4.5 31.2 1.0 HD13 A:ILE241 4.5 34.5 1.0 HE1 A:PHE527 4.5 35.6 1.0 HD1 A:PHE527 4.5 35.6 1.0 HB A:ILE241 4.6 34.5 1.0 C A:LEU526 4.6 32.5 1.0 CZ A:PHE527 4.7 35.6 1.0 CG1 A:ILE241 4.7 34.5 1.0 HE1 A:PHE518 4.7 29.7 1.0 CG A:PHE527 4.7 35.6 1.0 C A:SER239 4.8 30.0 1.0 O A:GLY283 4.9 33.1 1.0 O A:SER239 4.9 30.0 1.0 HD23 A:LEU526 4.9 32.5 1.0 H A:ILE241 5.0 34.5 1.0 CD1 A:TYR630 5.0 34.2 1.0

Chlorine binding site 3 out of 6 in the Cryo-Em Structure of Apo State Mclc-3


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Cryo-Em Structure of Apo State Mclc-3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl903 b:30.0 occ:1.00 H A:GLY240 2.8 31.9 1.0 HD2 A:PRO242 3.1 33.9 1.0 HG2 A:PRO242 3.1 33.9 1.0 HA3 A:GLY238 3.3 30.0 1.0 OE1 A:GLU243 3.5 35.8 1.0 H A:SER239 3.6 30.0 1.0 N A:GLY240 3.6 31.9 1.0 HA2 A:GLY240 3.7 31.9 1.0 CD A:PRO242 3.9 33.9 1.0 CG A:PRO242 3.9 33.9 1.0 N A:SER239 3.9 30.0 1.0 CA A:GLY238 4.1 30.0 1.0 HB2 A:PRO242 4.2 33.9 1.0 HB3 A:SER239 4.2 30.0 1.0 CA A:GLY240 4.2 31.9 1.0 HD3 A:PRO242 4.2 33.9 1.0 C A:GLY238 4.3 30.0 1.0 HH A:TYR256 4.3 35.2 1.0 HA2 A:GLY238 4.5 30.0 1.0 CD A:GLU243 4.5 35.8 1.0 CB A:PRO242 4.6 33.9 1.0 HG3 A:PRO242 4.6 33.9 1.0 HZ A:PHE518 4.6 29.7 1.0 C A:SER239 4.7 30.0 1.0 H A:GLU243 4.7 35.8 1.0 CA A:SER239 4.7 30.0 1.0 OH A:TYR256 4.8 35.2 1.0 OE2 A:GLU243 4.8 35.8 1.0 H A:ILE241 4.8 34.5 1.0 O A:CYS237 4.8 33.8 1.0 CB A:SER239 4.9 30.0 1.0 C A:GLY240 5.0 31.9 1.0 HA3 A:GLY240 5.0 31.9 1.0

Chlorine binding site 4 out of 6 in the Cryo-Em Structure of Apo State Mclc-3


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Cryo-Em Structure of Apo State Mclc-3 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl901 b:30.0 occ:1.00 HB2 B:GLU282 1.6 36.7 1.0 H B:GLU282 1.9 36.7 1.0 HB2 B:PHE527 2.4 35.5 1.0 CB B:GLU282 2.5 36.7 1.0 N B:GLU282 2.6 36.7 1.0 H B:GLY283 2.6 32.8 1.0 OE1 B:GLU282 2.7 36.7 1.0 H B:ILE528 2.8 34.5 1.0 HA3 B:GLY280 2.9 30.6 1.0 H B:PHE527 2.9 35.5 1.0 CA B:GLU282 2.9 36.7 1.0 HB3 B:GLU282 3.0 36.7 1.0 H B:LYS281 3.1 33.0 1.0 N B:GLY283 3.3 32.8 1.0 HB B:ILE528 3.3 34.5 1.0 CB B:PHE527 3.4 35.5 1.0 CD B:GLU282 3.5 36.7 1.0 CG B:GLU282 3.5 36.7 1.0 N B:LYS281 3.5 33.0 1.0 N B:ILE528 3.5 34.5 1.0 HD2 B:PRO284 3.6 31.1 1.0 C B:GLU282 3.6 36.7 1.0 N B:PHE527 3.6 35.5 1.0 HG22 B:ILE528 3.7 34.5 1.0 HA3 B:GLY525 3.7 29.1 1.0 C B:LYS281 3.7 33.0 1.0 CA B:GLY280 3.8 30.6 1.0 HA B:GLU282 3.8 36.7 1.0 HB3 B:PHE527 3.9 35.5 1.0 C B:GLY280 3.9 30.6 1.0 CA B:PHE527 3.9 35.5 1.0 HG2 B:GLU282 3.9 36.7 1.0 H B:LEU526 4.0 32.3 1.0 HD2 B:PHE527 4.1 35.5 1.0 CB B:ILE528 4.1 34.5 1.0 C B:PHE527 4.2 35.5 1.0 CA B:LYS281 4.2 33.0 1.0 CG B:PHE527 4.2 35.5 1.0 HG3 B:GLU282 4.2 36.7 1.0 CG2 B:ILE528 4.2 34.5 1.0 HA2 B:GLY280 4.3 30.6 1.0 N B:LEU526 4.4 32.3 1.0 CA B:ILE528 4.4 34.5 1.0 HG21 B:ILE528 4.4 34.5 1.0 CD2 B:PHE527 4.4 35.5 1.0 CD B:PRO284 4.5 31.1 1.0 HA B:LYS281 4.5 33.0 1.0 CA B:GLY525 4.6 29.1 1.0 CA B:GLY283 4.6 32.8 1.0 OE2 B:GLU282 4.6 36.7 1.0 HD3 B:PRO284 4.6 31.1 1.0 HA3 B:GLY283 4.6 32.8 1.0 H B:GLY280 4.7 30.6 1.0 HD2 B:PRO529 4.7 33.0 1.0 N B:GLY280 4.7 30.6 1.0 HD3 B:PRO529 4.7 33.0 1.0 C B:GLY525 4.7 29.1 1.0 C B:LEU526 4.7 32.3 1.0 O B:LYS281 4.8 33.0 1.0 HA B:ILE528 4.8 34.5 1.0 O B:GLU282 4.8 36.7 1.0 HA B:PHE527 4.8 35.5 1.0 O B:GLY280 4.8 30.6 1.0

Chlorine binding site 5 out of 6 in the Cryo-Em Structure of Apo State Mclc-3


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Cryo-Em Structure of Apo State Mclc-3 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl902 b:30.0 occ:1.00 HG B:SER239 1.7 29.9 1.0 OH B:TYR630 1.8 34.0 1.0 HH B:TYR630 2.0 34.0 1.0 OG B:SER239 2.2 29.9 1.0 HA3 B:GLY283 2.3 32.8 1.0 H B:LEU526 2.8 32.3 1.0 HD12 B:ILE241 2.9 34.1 1.0 CZ B:TYR630 3.0 34.0 1.0 HB2 B:SER239 3.0 29.9 1.0 CB B:SER239 3.1 29.9 1.0 HB3 B:LEU526 3.2 32.3 1.0 CA B:GLY283 3.3 32.8 1.0 HA2 B:GLY525 3.4 29.1 1.0 HE1 B:TYR630 3.4 34.0 1.0 HD3 B:PRO284 3.5 31.1 1.0 N B:LEU526 3.5 32.3 1.0 HA2 B:GLY283 3.6 32.8 1.0 CE1 B:TYR630 3.6 34.0 1.0 H B:GLY283 3.7 32.8 1.0 HD11 B:ILE241 3.8 34.1 1.0 CD1 B:ILE241 3.8 34.1 1.0 HB3 B:SER239 3.8 29.9 1.0 CE2 B:TYR630 4.0 34.0 1.0 N B:GLY283 4.0 32.8 1.0 H B:PHE527 4.0 35.5 1.0 HE2 B:TYR630 4.0 34.0 1.0 CB B:LEU526 4.0 32.3 1.0 HA B:SER239 4.1 29.9 1.0 CA B:GLY525 4.1 29.1 1.0 C B:GLY283 4.1 32.8 1.0 HA3 B:GLY525 4.2 29.1 1.0 CA B:SER239 4.2 29.9 1.0 CA B:LEU526 4.2 32.3 1.0 CD B:PRO284 4.2 31.1 1.0 HB2 B:LEU526 4.2 32.3 1.0 C B:GLY525 4.3 29.1 1.0 CE1 B:PHE527 4.3 35.5 1.0 CD1 B:PHE527 4.4 35.5 1.0 HG13 B:ILE241 4.4 34.1 1.0 HD13 B:ILE241 4.4 34.1 1.0 HE1 B:PHE527 4.4 35.5 1.0 N B:PHE527 4.4 35.5 1.0 HD2 B:PRO284 4.4 31.1 1.0 HB B:ILE241 4.5 34.1 1.0 HD1 B:PHE527 4.5 35.5 1.0 N B:PRO284 4.5 31.1 1.0 CG1 B:ILE241 4.6 34.1 1.0 CZ B:PHE527 4.6 35.5 1.0 C B:LEU526 4.6 32.3 1.0 CG B:PHE527 4.7 35.5 1.0 HE1 B:PHE518 4.8 29.6 1.0 C B:SER239 4.8 29.9 1.0 O B:GLY283 4.9 32.8 1.0 CD1 B:TYR630 4.9 34.0 1.0 O B:SER239 4.9 29.9 1.0 H B:ILE241 4.9 34.1 1.0 HD23 B:LEU526 4.9 32.3 1.0 HZ B:PHE527 5.0 35.5 1.0 CE2 B:PHE527 5.0 35.5 1.0

Chlorine binding site 6 out of 6 in the Cryo-Em Structure of Apo State Mclc-3


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Cryo-Em Structure of Apo State Mclc-3 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl903 b:30.0 occ:1.00 H B:GLY240 2.8 31.6 1.0 HD2 B:PRO242 3.1 33.8 1.0 HG2 B:PRO242 3.1 33.8 1.0 HA3 B:GLY238 3.3 29.9 1.0 OE1 B:GLU243 3.4 35.6 1.0 H B:SER239 3.6 29.9 1.0 N B:GLY240 3.6 31.6 1.0 HA2 B:GLY240 3.7 31.6 1.0 CD B:PRO242 3.8 33.8 1.0 CG B:PRO242 3.9 33.8 1.0 N B:SER239 3.9 29.9 1.0 HB2 B:PRO242 4.1 33.8 1.0 OE2 B:GLU243 4.1 35.6 1.0 CA B:GLY238 4.1 29.9 1.0 CD B:GLU243 4.2 35.6 1.0 HB3 B:SER239 4.2 29.9 1.0 CA B:GLY240 4.2 31.6 1.0 HD3 B:PRO242 4.2 33.8 1.0 C B:GLY238 4.3 29.9 1.0 HH B:TYR256 4.3 34.8 1.0 HA2 B:GLY238 4.5 29.9 1.0 CB B:PRO242 4.6 33.8 1.0 HG3 B:PRO242 4.6 33.8 1.0 HZ B:PHE518 4.6 29.6 1.0 C B:SER239 4.7 29.9 1.0 H B:GLU243 4.7 35.6 1.0 CA B:SER239 4.7 29.9 1.0 H B:ILE241 4.8 34.1 1.0 OH B:TYR256 4.8 34.8 1.0 O B:CYS237 4.8 33.5 1.0 CB B:SER239 4.9 29.9 1.0 C B:GLY240 5.0 31.6 1.0 HA3 B:GLY240 5.0 31.6 1.0

Y.Wan, S.Guo, W.Zhen, L.Xu, X.Chen, F.Liu, Y.Shen, S.Liu, L.Hu, X.Wang, F.Ye, Q.Wang, H.Wen, F.Yang. Structural Basis of Adenine Nucleotides Regulation and Neurodegenerative Pathology in Clc-3 Exchanger. Nat Commun V. 15 6654 2024.
ISSN: ESSN 2041-1723
PubMed: 39107281
DOI: 10.1038/S41467-024-50975-W