Chlorine in PDB 8kcu: Cryo-Em Structure of Human Gamma-Secretase in Complex with Mk-0752

The structure of Cryo-Em Structure of Human Gamma-Secretase in Complex with Mk-0752 also contains other interesting chemical elements:

Fluorine

(F)

2 atoms

The binding sites of Chlorine atom in the Cryo-Em Structure of Human Gamma-Secretase in Complex with Mk-0752 (pdb code 8kcu). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Cryo-Em Structure of Human Gamma-Secretase in Complex with Mk-0752, PDB code: 8kcu:

Chlorine binding site 1 out of 1 in the Cryo-Em Structure of Human Gamma-Secretase in Complex with Mk-0752


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Human Gamma-Secretase in Complex with Mk-0752 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl502 b:60.3 occ:1.00 CL01 B:OL9502 0.0 60.3 1.0 C29 B:OL9502 1.8 60.3 1.0 C28 B:OL9502 2.7 60.3 1.0 C27 B:OL9502 2.8 60.3 1.0 CG2 B:THR421 3.0 54.5 1.0 CB B:THR421 3.4 54.5 1.0 CB B:ALA434 3.6 54.5 1.0 CD1 B:LEU418 3.6 51.1 1.0 C22 B:OL9502 4.0 60.3 1.0 C21 B:OL9502 4.0 60.3 1.0 CD2 B:LEU422 4.1 54.8 1.0 CA B:ALA434 4.1 54.5 1.0 N B:LEU422 4.2 54.8 1.0 CG B:LEU422 4.2 54.8 1.0 O B:LEU418 4.3 51.1 1.0 C B:THR421 4.3 54.5 1.0 OG1 B:THR421 4.3 54.5 1.0 CA B:THR421 4.5 54.5 1.0 C17 B:OL9502 4.5 60.3 1.0 CD1 B:LEU381 4.6 55.7 1.0 O B:THR421 4.8 54.5 1.0 CA B:LEU422 4.8 54.8 1.0 CG B:LEU418 4.8 51.1 1.0 CA B:LEU418 5.0 51.1 1.0

X.Guo, H.Li, U.Kai, C.Yan, J.Lei, R.Zhou, Y.Shi. Structural Basis of Gamma-Secretase Inhibition By Anti-Cancer Clinical Drugs To Be Published.