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Chlorine in PDB 8kfd: Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy

Enzymatic activity of Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy

All present enzymatic activity of Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy:
1.16.3.1;

Protein crystallography data

The structure of Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy, PDB code: 8kfd was solved by X.Chen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.30 / 1.80
Space group F 4 3 2
Cell size a, b, c (Å), α, β, γ (°) 183.45, 183.45, 183.45, 90, 90, 90
R / Rfree (%) 15.3 / 16.6

Other elements in 8kfd:

The structure of Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy also contains other interesting chemical elements:

Magnesium (Mg) 3 atoms
Calcium (Ca) 1 atom
Platinum (Pt) 1 atom

Chlorine Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Chlorine atom in the Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy (pdb code 8kfd). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 12 binding sites of Chlorine where determined in the Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy, PDB code: 8kfd:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 12 in 8kfd

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Chlorine binding site 1 out of 12 in the Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl206

b:18.8
occ:0.25
 NE2 A:HIS173 3.2 23.1 1.0
CE1 A:HIS173 4.0 25.7 1.0
CD2 A:LEU169 4.0 18.4 1.0
CD2 A:HIS173 4.2 20.0 1.0
CD1 A:LEU169 4.9 18.4 1.0

Chlorine binding site 2 out of 12 in 8kfd

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Chlorine binding site 2 out of 12 in the Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl207

b:65.1
occ:1.00
 O A:HOH512 2.2 43.6 1.0
O A:HOH366 2.8 24.4 1.0
O A:ARG22 2.9 17.0 0.5
O A:ARG22 2.9 16.8 0.5
C A:ARG22 3.6 19.6 0.5
C A:ARG22 3.7 19.6 0.5
O A:HOH309 3.7 31.1 1.0
CA A:ARG22 3.8 16.4 0.5
CB A:ARG22 3.8 18.1 0.5
CA A:ARG22 3.8 16.4 0.5
CB A:ARG22 3.9 18.2 0.5
O A:HOH362 4.0 33.4 1.0
CB A:ASN25 4.0 14.3 1.0
OD1 A:ASN25 4.0 17.0 1.0
N A:LEU26 4.1 15.3 1.0
CB A:LEU26 4.3 15.0 1.0
CG A:ASN25 4.4 14.5 1.0
CG A:ARG22 4.5 22.8 0.5
CG A:ARG22 4.5 22.8 0.5
CA A:LEU26 4.6 13.9 1.0
C A:ASN25 4.7 15.2 1.0
CA A:ASN25 4.8 14.7 1.0
N A:GLN23 4.8 15.4 1.0
CD A:ARG22 5.0 29.1 0.5

Chlorine binding site 3 out of 12 in 8kfd

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Chlorine binding site 3 out of 12 in the Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl208

b:33.3
occ:0.90
 N A:GLN14 3.2 17.4 1.0
CG A:GLN14 3.2 27.9 0.6
O A:HOH490 3.6 39.6 1.0
CG A:GLN14 3.6 21.7 0.4
CB A:GLN14 3.8 23.3 0.6
CD2 A:HIS13 3.8 25.1 1.0
CG A:HIS13 3.8 23.4 1.0
CA A:HIS13 3.8 16.1 1.0
CB A:GLN14 3.9 23.7 0.4
NE2 A:HIS13 3.9 26.5 1.0
ND1 A:HIS13 3.9 22.0 1.0
CE1 A:HIS13 4.0 23.5 1.0
C A:HIS13 4.0 18.4 1.0
O A:HOH320 4.1 55.5 1.0
CA A:GLN14 4.1 19.1 0.6
CA A:GLN14 4.1 19.1 0.4
CD A:GLN14 4.4 29.3 0.4
CB A:HIS13 4.4 17.6 1.0
CD A:GLN14 4.5 46.5 0.6
OE1 A:GLN14 4.5 31.8 0.4
O A:TYR12 4.6 20.1 1.0
NE2 A:GLN14 4.8 46.0 0.6
N A:HIS13 5.0 15.8 1.0

Chlorine binding site 4 out of 12 in 8kfd

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Chlorine binding site 4 out of 12 in the Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl209

b:33.8
occ:0.80
 O A:HOH483 2.7 33.7 1.0
O A:HOH480 3.0 47.3 1.0
ND2 A:ASN21 3.3 17.5 1.0
CB A:ASN21 3.9 16.5 1.0
CA A:ALA18 3.9 16.7 1.0
CB A:PHE81 4.0 18.8 0.6
CD2 A:PHE81 4.0 38.2 0.4
CG A:ASN21 4.1 18.8 1.0
CB A:ALA18 4.1 17.3 1.0
CD2 A:PHE81 4.1 28.9 0.6
CB A:PHE81 4.3 22.9 0.4
CG A:PHE81 4.3 17.8 0.6
O A:HOH409 4.3 25.9 1.0
O A:ALA18 4.4 17.9 1.0
CG A:PHE81 4.6 28.1 0.4
O A:HOH311 4.6 43.8 1.0
C A:ALA18 4.7 15.9 1.0
N A:ALA18 4.9 16.4 1.0
O A:HOH430 4.9 29.3 1.0
O A:HOH468 4.9 42.1 1.0

Chlorine binding site 5 out of 12 in 8kfd

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Chlorine binding site 5 out of 12 in the Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl210

b:29.2
occ:0.70
 O A:THR135 3.0 24.1 1.0
N A:ASN139 3.1 17.5 1.0
N A:GLU140 3.1 18.7 0.5
N A:GLU140 3.1 18.7 0.5
O A:HOH441 3.3 28.0 1.0
O A:GLU134 3.3 23.5 0.5
O A:HOH431 3.4 37.0 1.0
N A:TYR137 3.4 18.0 1.0
CB A:ASN139 3.5 20.4 1.0
C A:HIS136 3.5 22.5 1.0
O A:GLU134 3.5 23.4 0.5
C A:THR135 3.5 25.6 1.0
CA A:ASN139 3.6 18.9 1.0
N A:LEU138 3.7 17.3 1.0
C A:TYR137 3.7 18.3 1.0
CG A:GLU140 3.7 23.6 0.5
C A:ASN139 3.8 19.4 1.0
O A:HIS136 3.9 21.0 1.0
N A:HIS136 3.9 16.6 1.0
CA A:HIS136 4.0 15.9 1.0
CA A:TYR137 4.0 17.5 1.0
C A:LEU138 4.1 17.0 1.0
CB A:GLU140 4.1 22.4 0.5
CB A:GLU140 4.1 22.4 0.5
O A:TYR137 4.1 19.3 1.0
CA A:GLU140 4.2 20.8 0.5
CA A:GLU140 4.2 20.8 0.5
C A:GLU134 4.4 21.8 0.5
CA A:LEU138 4.4 15.8 1.0
C A:GLU134 4.5 21.8 0.5
O A:HOH385 4.5 33.7 1.0
CA A:THR135 4.5 20.1 1.0
O A:HOH356 4.6 42.0 1.0
CD A:GLU140 4.7 31.8 0.0
OE2 A:GLU140 4.7 36.9 0.5
O A:HOH500 4.8 41.9 1.0
CG A:ASN139 4.8 25.4 1.0
N A:THR135 4.9 19.6 1.0
O A:ASN139 4.9 18.0 1.0

Chlorine binding site 6 out of 12 in 8kfd

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Chlorine binding site 6 out of 12 in the Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl211

b:26.8
occ:0.80
 O A:HOH410 2.5 32.8 1.0
O A:HOH470 2.9 42.8 1.0
NE2 A:GLN75 3.1 23.1 1.0
CG A:GLN75 3.8 19.5 1.0
CD A:GLN75 3.9 27.1 1.0
NZ A:LYS71 4.1 33.7 0.5
CE A:LYS71 4.2 30.9 0.5
CE A:LYS71 4.3 31.1 0.5
NZ A:LYS71 4.8 34.4 0.5

Chlorine binding site 7 out of 12 in 8kfd

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Chlorine binding site 7 out of 12 in the Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl212

b:24.9
occ:0.80
 OE1 A:GLN83 2.7 25.9 0.0
N A:ASP84 3.2 14.7 1.0
OD1 A:ASP84 3.6 19.6 1.0
CG A:ASP84 3.6 20.8 1.0
CB A:GLN83 3.6 19.5 0.5
CA A:GLN83 3.6 19.1 0.5
CA A:GLN83 3.7 19.1 0.5
CB A:GLN83 3.7 19.4 0.5
CD A:GLN83 3.8 26.1 0.0
OD2 A:ASP84 3.9 20.2 1.0
C A:GLN83 3.9 16.9 0.5
C A:GLN83 3.9 16.9 0.5
CG A:GLN83 4.0 24.6 0.5
CB A:ASP84 4.0 16.3 1.0
CA A:ASP84 4.2 12.8 1.0
CG A:GLN83 4.3 22.4 0.5
CD A:GLN83 4.5 29.8 0.5
O A:HOH370 4.6 17.2 0.9
O A:HOH325 4.6 21.8 0.5
NE2 A:GLN83 4.6 43.1 0.5
CA A:CA205 4.7 23.9 0.3
O A:HOH363 4.8 23.8 1.0
NE2 A:GLN83 4.9 39.3 0.5

Chlorine binding site 8 out of 12 in 8kfd

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Chlorine binding site 8 out of 12 in the Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl213

b:48.1
occ:0.90
 N A:ASN11 3.0 18.9 1.0
CA A:GLN10 3.8 15.7 1.0
CL A:CL216 3.8 25.4 0.8
C A:GLN10 3.9 20.3 1.0
CA A:ASN11 3.9 15.7 1.0
CG A:GLN10 4.1 25.5 1.0
CB A:GLN10 4.5 17.2 1.0
CB A:ASN11 4.7 18.4 1.0
O A:ARG9 4.9 19.2 1.0
N A:GLN10 4.9 15.9 1.0

Chlorine binding site 9 out of 12 in 8kfd

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Chlorine binding site 9 out of 12 in the Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl214

b:32.0
occ:0.25
 CE1 A:HIS173 3.6 25.7 1.0
ND1 A:HIS173 4.3 25.9 1.0
NE2 A:HIS173 4.5 23.1 1.0
O A:HOH427 4.8 41.9 1.0

Chlorine binding site 10 out of 12 in 8kfd

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Chlorine binding site 10 out of 12 in the Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl215

b:27.4
occ:0.80
 ND2 A:ASN139 3.4 20.8 1.0
O A:HOH487 3.5 49.5 1.0
CD A:LYS143 3.8 22.2 1.0
O A:HOH347 3.9 26.5 1.0
CG A:LYS143 4.1 19.6 1.0
OD1 A:ASN139 4.1 21.6 1.0
CG A:ASN139 4.2 25.4 1.0

Reference:

B.Jiang, X.Chen, K.Fan. Ferritin Drug Carrier(Fdc) For Encapsulated Platinum (IV) Prodrug For Esophageal Squamous Cell Carcinoma Targeted Therapy To Be Published.
Page generated: Tue Jul 30 11:05:39 2024

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