Chlorine in PDB 8p19: USP28 Usp Domain Apo

All present enzymatic activity of USP28 Usp Domain Apo:
3.4.19.12;

The structure of USP28 Usp Domain Apo, PDB code: 8p19 was solved by F.Sauer, R.Karal Nair, C.Kisker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.97 / 2.45
Space group	H 3 2
Cell size a, b, c (Å), α, β, γ (°)	106.634, 106.634, 329.857, 90, 90, 120
R / Rfree (%)	19.4 / 22.2

The binding sites of Chlorine atom in the USP28 Usp Domain Apo (pdb code 8p19). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the USP28 Usp Domain Apo, PDB code: 8p19:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the USP28 Usp Domain Apo


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of USP28 Usp Domain Apo within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl602 b:109.4 occ:1.00 ND2 A:ASN321 3.6 79.1 1.0 O A:GLY322 3.8 58.9 1.0 O A:HOH767 3.8 79.8 1.0 C A:GLY322 4.1 57.9 1.0 CD1 A:TYR323 4.5 55.4 1.0 CE1 A:TYR323 4.5 47.0 1.0 CG A:ASN321 4.5 83.9 1.0 N A:TYR323 4.6 44.6 1.0 CA A:GLY322 4.6 57.5 1.0 OD1 A:ASN321 4.7 124.3 1.0 N A:GLY322 4.8 65.0 1.0 CA A:TYR323 5.0 58.3 1.0

Chlorine binding site 2 out of 4 in the USP28 Usp Domain Apo


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of USP28 Usp Domain Apo within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl603 b:96.4 occ:1.00 NZ A:LYS441 3.5 89.4 1.0 ND2 A:ASN443 3.6 71.2 1.0 OE2 A:GLU419 3.8 99.9 1.0 CZ3 A:TRP428 4.0 63.6 1.0 CH2 A:TRP428 4.0 72.2 1.0 CE A:LYS441 4.1 66.6 1.0 CE3 A:TRP428 4.2 62.4 1.0 CZ2 A:TRP428 4.3 54.0 1.0 CD2 A:TRP428 4.4 63.8 1.0 CE2 A:TRP428 4.4 58.8 1.0 CG A:ASN443 4.4 64.5 1.0 CD A:GLU419 4.6 101.7 1.0 CD2 A:HIS426 4.8 82.6 1.0 OD1 A:ASN443 4.8 69.9 1.0 OE1 A:GLU419 4.9 98.6 1.0 O A:HOH781 4.9 76.5 1.0

Chlorine binding site 3 out of 4 in the USP28 Usp Domain Apo


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of USP28 Usp Domain Apo within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl604 b:66.6 occ:1.00 N A:ARG464 3.6 48.8 1.0 CG A:ARG464 3.9 53.1 1.0 CD2 A:LEU463 4.0 43.6 1.0 CB A:ARG464 4.1 47.0 1.0 CA A:LEU463 4.3 48.7 1.0 CD A:ARG464 4.3 51.1 1.0 CB A:LEU463 4.4 45.0 1.0 CA A:ARG464 4.5 57.5 1.0 C A:LEU463 4.5 55.5 1.0 NE A:ARG464 4.7 53.2 1.0 CG A:LEU463 4.8 57.8 1.0 O A:ARG464 5.0 57.3 1.0

Chlorine binding site 4 out of 4 in the USP28 Usp Domain Apo


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of USP28 Usp Domain Apo within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl605 b:57.2 occ:1.00 O A:HOH754 3.1 47.9 1.0 CD A:PRO389 3.6 48.1 1.0 N A:PRO389 3.6 47.8 1.0 CA A:PHE388 3.6 44.3 1.0 C A:PHE388 3.6 45.3 1.0 N A:PHE388 3.7 48.0 1.0 C A:GLU387 3.9 52.0 1.0 O A:GLU387 3.9 48.6 1.0 CB A:ASN325 4.0 36.9 1.0 CB A:PRO389 4.2 39.3 1.0 CG A:PRO389 4.2 44.8 1.0 CB A:GLU387 4.2 36.7 1.0 CA A:PRO389 4.3 40.3 1.0 O A:PHE388 4.3 49.8 1.0 CA A:GLU387 4.7 45.9 1.0 OE1 A:GLU387 4.9 58.2 1.0 CG A:ASN325 4.9 56.0 1.0 N A:LEU326 4.9 47.6 1.0

F.Sauer, R.Karal Nair, C.Kisker. USP28 Usp Domain Apo To Be Published.