Chlorine in PDB 8p1i: Single Particle Cryo-Em Co-Structure of Klebsiella Pneumoniae Acrb with the BDM91288 Efflux Pump Inhibitor at 2.97 Angstrom Resolution

The binding sites of Chlorine atom in the Single Particle Cryo-Em Co-Structure of Klebsiella Pneumoniae Acrb with the BDM91288 Efflux Pump Inhibitor at 2.97 Angstrom Resolution (pdb code 8p1i). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Single Particle Cryo-Em Co-Structure of Klebsiella Pneumoniae Acrb with the BDM91288 Efflux Pump Inhibitor at 2.97 Angstrom Resolution, PDB code: 8p1i:

Chlorine binding site 1 out of 1 in the Single Particle Cryo-Em Co-Structure of Klebsiella Pneumoniae Acrb with the BDM91288 Efflux Pump Inhibitor at 2.97 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Single Particle Cryo-Em Co-Structure of Klebsiella Pneumoniae Acrb with the BDM91288 Efflux Pump Inhibitor at 2.97 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1101 b:73.1 occ:1.00 CL1 A:WQW1101 0.0 73.1 1.0 C12 A:WQW1101 1.7 73.1 1.0 H16 A:WQW1101 2.6 73.1 1.0 C11 A:WQW1101 2.6 73.1 1.0 H15 A:WQW1101 2.7 73.1 1.0 H14 A:WQW1101 2.7 73.1 1.0 C13 A:WQW1101 2.8 73.1 1.0 HG A:LEU943 2.8 73.3 1.0 C14 A:WQW1101 2.9 73.1 1.0 N4 A:WQW1101 3.1 73.1 1.0 HG21 A:ILE445 3.2 68.0 1.0 HG22 A:ILE942 3.3 69.2 1.0 HG2 A:LYS939 3.4 69.1 1.0 HD23 A:LEU943 3.6 73.3 1.0 CG A:LEU943 3.7 73.3 1.0 HD13 A:ILE445 3.7 68.0 1.0 HD21 A:LEU943 3.8 73.3 1.0 HG3 A:LYS939 3.8 69.1 1.0 CD2 A:LEU943 3.9 73.3 1.0 C7 A:WQW1101 4.0 73.1 1.0 O A:LYS939 4.0 69.1 1.0 N3 A:WQW1101 4.0 73.1 1.0 HB A:ILE942 4.0 69.2 1.0 CG A:LYS939 4.1 69.1 1.0 CG2 A:ILE445 4.1 68.0 1.0 HA A:LEU943 4.1 73.3 1.0 HG22 A:ILE445 4.1 68.0 1.0 CG2 A:ILE942 4.1 69.2 1.0 H A:LEU943 4.2 73.3 1.0 HG21 A:ILE942 4.3 69.2 1.0 HD12 A:ILE445 4.3 68.0 1.0 N A:LEU943 4.3 73.3 1.0 C15 A:WQW1101 4.4 73.1 1.0 HB3 A:ASP407 4.4 73.2 1.0 HA A:LYS939 4.4 69.1 1.0 CD1 A:ILE445 4.5 68.0 1.0 C8 A:WQW1101 4.5 73.1 1.0 HD11 A:LEU943 4.5 73.3 1.0 CA A:LEU943 4.5 73.3 1.0 C17 A:WQW1101 4.5 73.1 1.0 HD11 A:LEU449 4.6 67.0 1.0 H18 A:WQW1101 4.6 73.1 1.0 CB A:LEU943 4.6 73.3 1.0 HG23 A:ILE445 4.6 68.0 1.0 CB A:ILE942 4.6 69.2 1.0 CD1 A:LEU943 4.6 73.3 1.0 HB2 A:ASP407 4.7 73.2 1.0 HD2 A:LYS939 4.8 69.1 1.0 H22 A:WQW1101 4.8 73.1 1.0 H17 A:WQW1101 4.8 73.1 1.0 HE3 A:LYS939 4.8 69.1 1.0 HD12 A:LEU943 4.8 73.3 1.0 C A:ILE942 4.8 69.2 1.0 C A:LYS939 4.9 69.1 1.0 H23 A:WQW1101 4.9 73.1 1.0 HD22 A:LEU943 4.9 73.3 1.0 HG23 A:ILE942 4.9 69.2 1.0 HB2 A:LEU943 4.9 73.3 1.0 HB A:ILE445 4.9 68.0 1.0 CB A:ASP407 4.9 73.2 1.0 CD A:LYS939 5.0 69.1 1.0

A.Vieira Da Cruz, J.C.Jimenez-Castellanos, C.Bornsen, L.Van Maele, N.Compagne, E.Pradel, R.T.Muller, V.Meurillon, D.Soulard, C.Piveteau, A.Biela, J.Dumont, F.Leroux, B.Deprez, N.Willand, K.M.Pos, A.S.Frangakis, R.C.Hartkoorn, M.Flipo. Pyridylpiperazine Efflux Pump Inhibitor Boosts in Vivo Antibiotic Efficacy Against K. Pneumoniae. Embo Mol Med 2023.
ISSN: ESSN 1757-4684
PubMed: 38177534
DOI: 10.1038/S44321-023-00007-9