Chlorine in PDB 8pd6: Crystal Structure of the TRIM58 Pry-Spry Domain in Complex with Trim- 473

Enzymatic activity of Crystal Structure of the TRIM58 Pry-Spry Domain in Complex with Trim- 473

All present enzymatic activity of Crystal Structure of the TRIM58 Pry-Spry Domain in Complex with Trim- 473:
2.3.2.27;

Protein crystallography data

The structure of Crystal Structure of the TRIM58 Pry-Spry Domain in Complex with Trim- 473, PDB code: 8pd6 was solved by M.Renatus, K.Hoegenauer, M.Schroeder, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.01 / 1.30
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 55.284, 55.284, 202.763, 90, 90, 120
R / Rfree (%) 13.9 / 17.8

Other elements in 8pd6:

The structure of Crystal Structure of the TRIM58 Pry-Spry Domain in Complex with Trim- 473 also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the TRIM58 Pry-Spry Domain in Complex with Trim- 473 (pdb code 8pd6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the TRIM58 Pry-Spry Domain in Complex with Trim- 473, PDB code: 8pd6:

Chlorine binding site 1 out of 1 in 8pd6

Go back to Chlorine Binding Sites List in 8pd6
Chlorine binding site 1 out of 1 in the Crystal Structure of the TRIM58 Pry-Spry Domain in Complex with Trim- 473


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the TRIM58 Pry-Spry Domain in Complex with Trim- 473 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl504

b:15.6
occ:1.00
 N8 A:YCB501 3.3 12.1 1.0
C7 A:YCB501 3.7 11.1 1.0
CZ A:PHE449 3.9 12.1 1.0
C15 A:YCB501 3.9 12.0 1.0
CZ3 A:TRP332 3.9 16.3 1.0
C24 A:YCB501 4.1 14.0 1.0
CE3 A:TRP332 4.2 14.3 1.0
C2 A:YCB501 4.3 11.5 1.0
CD A:PRO333 4.4 14.0 1.0
CE1 A:PHE449 4.4 12.5 1.0
C3 A:YCB501 4.5 10.1 1.0
C28 A:YCB501 4.5 13.8 1.0
C9 A:YCB501 4.7 11.9 1.0
CG A:PRO333 4.7 13.9 1.0
C14 A:YCB501 4.7 11.4 1.0
C18 A:YCB501 4.8 12.5 1.0
C29 A:YCB501 4.9 13.6 1.0
CE2 A:PHE449 4.9 12.6 1.0

Reference:

K.Hoegenauer, S.An, J.Axford, C.Benander, C.Bergsdorf, J.Botsch, S.Chau, C.Fernandez, S.Gleim, U.Hassiepen, J.Hunziker, E.Joly, A.Keller, S.Lopez Romero, R.Maher, A.S.Mangold, C.Mickanin, M.Mihalic, P.Neuner, A.W.Patterson, F.Perruccio, S.Roggo, J.Scesa, M.Schroder, D.Shkoza, B.Thai, A.Vulpetti, M.Renatus, J.S.Reece-Hoyes. Discovery of Ligands For TRIM58, A Novel Tissue-Selective E3 Ligase Acs Med.Chem.Lett. 2023.
ISSN: ISSN 1948-5875
DOI: 10.1021/ACSMEDCHEMLETT.3C00259
Page generated: Tue Jul 30 11:32:29 2024

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