Chlorine in PDB 8q38: Crystal Structure of YTHDC1 in Complex with Compound 19 (ZA_347)

The structure of Crystal Structure of YTHDC1 in Complex with Compound 19 (ZA_347), PDB code: 8q38 was solved by R.K.Bedi, F.Zalesak, A.Caflisch, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.67 / 1.42
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	39.66, 103.89, 41.98, 90, 104.33, 90
R / Rfree (%)	20.8 / 22.8

The binding sites of Chlorine atom in the Crystal Structure of YTHDC1 in Complex with Compound 19 (ZA_347) (pdb code 8q38). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of YTHDC1 in Complex with Compound 19 (ZA_347), PDB code: 8q38:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of YTHDC1 in Complex with Compound 19 (ZA_347)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of YTHDC1 in Complex with Compound 19 (ZA_347) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl601 b:52.6 occ:1.00 CL01 A:IZJ601 0.0 52.6 1.0 C02 A:IZJ601 1.8 39.3 1.0 ND2 A:ASN367 2.6 33.3 1.0 ND2 A:ASN364 2.6 44.2 1.0 N23 A:IZJ601 2.8 41.5 1.0 N03 A:IZJ601 2.8 38.3 1.0 CG A:ASN364 3.3 39.1 1.0 O A:VAL429 3.5 49.8 1.0 N A:ASN363 3.5 31.4 1.0 CB A:ASN363 3.6 39.4 1.0 OD1 A:ASN364 3.6 33.1 1.0 N A:ASN364 3.6 27.8 1.0 CG A:ASN367 3.7 32.5 1.0 OG A:SER362 3.8 29.7 1.0 CA A:ASN363 3.9 38.2 1.0 CG A:PRO431 3.9 62.9 1.0 CD A:PRO431 4.0 59.5 1.0 C A:ASN363 4.1 33.8 1.0 C04 A:IZJ601 4.1 33.2 1.0 C08 A:IZJ601 4.2 40.6 1.0 CB A:ASN367 4.3 27.1 1.0 CB A:ASN364 4.3 33.3 1.0 CA A:ASN364 4.5 31.6 1.0 C A:SER362 4.5 27.4 1.0 OD1 A:ASN367 4.7 32.0 1.0 C07 A:IZJ601 4.7 38.0 1.0 CG A:ASN363 4.7 47.3 1.0 C A:VAL429 4.7 50.6 1.0 O A:ASN364 4.8 26.9 1.0 CA A:SER362 4.9 29.3 1.0 OD1 A:ASN363 4.9 49.3 1.0 CB A:SER362 4.9 28.5 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of YTHDC1 in Complex with Compound 19 (ZA_347)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of YTHDC1 in Complex with Compound 19 (ZA_347) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl601 b:38.5 occ:1.00 CL01 B:IZJ601 0.0 38.5 1.0 C02 B:IZJ601 1.8 31.0 1.0 N23 B:IZJ601 2.8 30.9 1.0 N03 B:IZJ601 2.8 32.2 1.0 ND2 B:ASN364 3.1 31.0 1.0 ND2 B:ASN367 3.2 30.1 1.0 CG B:ASN364 3.3 33.1 1.0 N B:ASN364 3.5 22.7 1.0 N B:ASN363 3.5 25.8 1.0 OD1 B:ASN364 3.6 31.2 1.0 OG B:SER362 3.6 25.8 1.0 CB B:ASN363 3.7 30.8 1.0 CA B:ASN363 3.9 29.2 1.0 CD B:PRO431 3.9 38.6 1.0 C B:ASN363 4.0 24.0 1.0 CG B:ASN367 4.1 24.6 1.0 O B:VAL429 4.1 33.4 1.0 CG B:PRO431 4.1 45.0 1.0 C04 B:IZJ601 4.1 28.9 1.0 CB B:ASN364 4.2 27.6 1.0 C08 B:IZJ601 4.2 34.4 1.0 CA B:ASN364 4.3 27.3 1.0 CB B:ASN367 4.3 20.1 1.0 C B:SER362 4.5 24.3 1.0 C07 B:IZJ601 4.7 31.4 1.0 CG B:ASN363 4.7 37.0 1.0 O B:ASN364 4.7 26.0 1.0 CA B:SER362 4.8 25.0 1.0 CB B:SER362 4.8 25.1 1.0 CB B:PRO431 4.8 43.2 1.0 C B:ASN364 5.0 22.8 1.0

R.K.Bedi, F.Zalesak, A.Caflisch. Crystal Structure of YTHDC1 in Complex with Compound 19 (ZA_347) To Be Published.