Chlorine in PDB 8q6e: Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide

Enzymatic activity of Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide

All present enzymatic activity of Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide:
1.14.11.29;

Protein crystallography data

The structure of Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide, PDB code: 8q6e was solved by G.Fiorini, W.D.Figg Jr, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.77 / 1.37
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 130.9, 38.12, 42.77, 90, 90, 90
R / Rfree (%) 18 / 20.5

Other elements in 8q6e:

The structure of Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide also contains other interesting chemical elements:

Iron (Fe) 1 atom
Magnesium (Mg) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide (pdb code 8q6e). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide, PDB code: 8q6e:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 8q6e

Go back to Chlorine Binding Sites List in 8q6e
Chlorine binding site 1 out of 2 in the Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl504

b:23.6
occ:0.00
 HE1 A:TRP367 2.3 25.6 1.0
O A:HOH737 2.6 36.4 1.0
O A:HOH778 2.8 31.7 1.0
O A:ASN203 3.1 25.3 1.0
NE1 A:TRP367 3.2 21.3 1.0
O A:MET202 3.3 20.4 1.0
H A:GLY206 3.6 22.5 1.0
N A:GLY206 3.7 18.7 1.0
HA3 A:GLY206 3.7 21.7 1.0
HH11 A:ARG371 3.8 28.4 1.0
C A:ASN203 3.8 21.4 1.0
HA A:ASN203 3.8 23.8 1.0
HA2 A:GLY206 3.9 21.7 1.0
HD1 A:TRP367 3.9 25.1 1.0
CD1 A:TRP367 4.0 20.9 1.0
CA A:GLY206 4.0 18.1 1.0
HZ2 A:TRP367 4.1 25.9 1.0
C A:HIS205 4.1 20.7 1.0
N A:HIS205 4.2 19.1 1.0
CE2 A:TRP367 4.2 19.6 1.0
C A:LYS204 4.2 20.9 1.0
NH1 A:ARG371 4.3 23.6 1.0
HH12 A:ARG371 4.3 28.4 1.0
CA A:ASN203 4.3 19.8 1.0
HD2 A:ARG371 4.3 26.1 1.0
H A:HIS205 4.3 22.9 1.0
O A:LYS204 4.4 24.6 1.0
C A:MET202 4.5 20.5 1.0
O A:HOH771 4.5 34.9 1.0
O A:HOH704 4.5 30.5 1.0
O A:HOH815 4.6 39.4 1.0
N A:LYS204 4.6 20.0 1.0
CZ2 A:TRP367 4.6 21.5 1.0
CA A:HIS205 4.6 19.5 1.0
HA A:HIS205 4.7 23.4 1.0
HA A:LYS204 4.8 25.7 1.0
O A:HIS205 4.8 19.8 1.0
CA A:LYS204 4.8 21.4 1.0
N A:ASN203 5.0 19.8 1.0

Chlorine binding site 2 out of 2 in 8q6e

Go back to Chlorine Binding Sites List in 8q6e
Chlorine binding site 2 out of 2 in the Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl505

b:28.4
occ:0.00
 H A:ILE292 2.0 22.9 1.0
O A:HOH739 2.3 40.5 1.0
H A:GLY285 2.4 36.9 1.0
O A:HOH766 2.6 40.6 1.0
HA A:ASN284 2.7 36.2 1.0
HA A:LYS291 2.8 27.5 1.0
N A:ILE292 2.8 19.1 1.0
O A:HOH638 3.1 31.2 1.0
N A:GLY285 3.1 30.7 1.0
HB A:ILE292 3.3 24.0 1.0
CA A:ASN284 3.5 30.2 1.0
CA A:LYS291 3.5 22.9 1.0
O A:HOH659 3.6 28.7 1.0
C A:LYS291 3.6 21.9 1.0
HG13 A:ILE292 3.7 25.7 1.0
C A:ASN284 3.8 24.9 1.0
CA A:ILE292 3.8 19.1 1.0
O A:ILE292 3.8 27.3 1.0
O A:TYR290 3.8 25.7 1.0
CB A:ILE292 3.9 20.0 1.0
CB A:ASN284 3.9 30.0 1.0
HA2 A:GLY285 3.9 30.1 1.0
CA A:GLY285 4.1 25.1 1.0
C A:ILE292 4.2 23.5 1.0
CG1 A:ILE292 4.3 21.4 1.0
N A:LYS291 4.4 23.5 1.0
C A:TYR290 4.4 23.3 1.0
HD12 A:ILE292 4.5 28.0 1.0
CB A:LYS291 4.6 29.3 1.0
HA3 A:GLY285 4.6 30.1 1.0
HA A:ILE292 4.6 22.9 1.0
N A:ASN284 4.6 29.0 1.0
O A:CYS283 4.7 27.6 1.0
O A:LYS291 4.8 25.6 1.0
CD1 A:ILE292 4.9 23.3 1.0
H A:LYS286 5.0 26.3 1.0
O A:HOH675 5.0 24.9 1.0
O A:ASN284 5.0 29.2 1.0

Reference:

G.Fiorini, W.D.Figg Jr, C.J.Schofield. Hif Prolyl Hydroxylase 2 in Complex with HIF2ALPHA-Codd To Be Published.
Page generated: Sat Sep 28 19:27:12 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy