Chlorine in PDB 8rpb: Structure of S79 Fab in Complex with Igv Domain of Human Pd-L1

The structure of Structure of S79 Fab in Complex with Igv Domain of Human Pd-L1, PDB code: 8rpb was solved by A.Svensson, V.Kelpsas, M.Laursen, N.Rose, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.24 / 2.79
Space group	P 62 2 2
Cell size a, b, c (Å), α, β, γ (°)	185.852, 185.852, 110.237, 90, 90, 120
R / Rfree (%)	22.9 / 25.1

The binding sites of Chlorine atom in the Structure of S79 Fab in Complex with Igv Domain of Human Pd-L1 (pdb code 8rpb). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of S79 Fab in Complex with Igv Domain of Human Pd-L1, PDB code: 8rpb:

Chlorine binding site 1 out of 1 in the Structure of S79 Fab in Complex with Igv Domain of Human Pd-L1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of S79 Fab in Complex with Igv Domain of Human Pd-L1 within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl301 b:90.6 occ:1.00 N H:TRP47 3.3 66.8 1.0 N L:PHE102 3.5 76.8 1.0 CA L:VAL101 3.7 75.5 1.0 CA H:GLU46 3.9 67.5 1.0 C L:VAL101 4.0 76.4 1.0 CB H:TRP47 4.1 66.2 1.0 C H:GLU46 4.1 67.5 1.0 CD2 L:PHE102 4.1 75.8 1.0 O L:HIS100 4.2 74.0 1.0 CA H:TRP47 4.2 67.0 1.0 CB L:PHE102 4.3 76.2 1.0 CG H:GLU46 4.3 69.4 1.0 CB L:VAL101 4.4 76.0 1.0 CA L:PHE102 4.5 77.4 1.0 O H:TRP47 4.5 69.2 1.0 O H:LEU45 4.5 71.2 1.0 CG1 L:VAL101 4.5 76.8 1.0 N L:VAL101 4.6 74.5 1.0 CB H:GLU46 4.6 67.8 1.0 CG L:PHE102 4.7 75.7 1.0 C L:HIS100 4.7 74.2 1.0 O L:PHE102 4.8 79.4 1.0 C H:TRP47 4.9 68.3 1.0

P.Malinge, X.Chauchet, J.Bourguignon, N.Bosson, S.Calloud, T.Bautzova, M.Borlet, M.Laursen, V.Kelpsas, N.Rose, F.Gueneau, U.Ravn, G.Magistrelli, N.Fischer. Structural Analysis of Light Chain-Driven Bispecific Antibodies Targeting CD47 and Pd-L1. Mabs V. 16 62432 2024.
ISSN: ESSN 1942-0870
PubMed: 38849989
DOI: 10.1080/19420862.2024.2362432