Chlorine in PDB 8si7: Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State
Enzymatic activity of Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State
All present enzymatic activity of Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State:
2.7.11.1;
Other elements in 8si7:
The structure of Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State
(pdb code 8si7). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 8 binding sites of Chlorine where determined in the
Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State, PDB code: 8si7:
Jump to Chlorine binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Chlorine binding site 1 out
of 8 in 8si7
Go back to
Chlorine Binding Sites List in 8si7
Chlorine binding site 1 out
of 8 in the Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl1304
b:12.9
occ:1.00
|
CL20
|
A:3FD1304
|
0.0
|
12.9
|
1.0
|
|
C16
|
A:3FD1304
|
1.8
|
12.9
|
1.0
|
|
C17
|
A:3FD1304
|
2.7
|
12.9
|
1.0
|
|
C15
|
A:3FD1304
|
2.8
|
12.9
|
1.0
|
|
H37
|
A:POV1301
|
2.8
|
15.7
|
1.0
|
|
H17
|
A:3FD1304
|
2.8
|
12.9
|
1.0
|
|
H33
|
A:POV1301
|
2.9
|
15.7
|
1.0
|
|
HG13
|
A:VAL974
|
3.0
|
32.8
|
1.0
|
|
HG11
|
A:VAL974
|
3.0
|
32.8
|
1.0
|
|
CL21
|
A:3FD1304
|
3.2
|
12.9
|
1.0
|
|
CG1
|
A:VAL974
|
3.3
|
32.8
|
1.0
|
|
HG12
|
A:VAL974
|
3.3
|
32.8
|
1.0
|
|
HD12
|
A:LEU977
|
3.4
|
33.5
|
1.0
|
|
H39
|
A:POV1301
|
3.5
|
15.7
|
1.0
|
|
HH
|
A:TYR923
|
3.6
|
37.6
|
1.0
|
|
C37
|
A:POV1301
|
3.7
|
15.7
|
1.0
|
|
H35A
|
A:POV1301
|
3.9
|
15.7
|
1.0
|
|
C33
|
A:POV1301
|
3.9
|
15.7
|
1.0
|
|
HE2
|
A:TYR923
|
3.9
|
37.6
|
1.0
|
|
HD13
|
A:LEU977
|
4.0
|
33.5
|
1.0
|
|
H37A
|
A:POV1301
|
4.0
|
15.7
|
1.0
|
|
C14
|
A:3FD1304
|
4.0
|
12.9
|
1.0
|
|
OH
|
A:TYR923
|
4.0
|
37.6
|
1.0
|
|
C18
|
A:3FD1304
|
4.0
|
12.9
|
1.0
|
|
H38A
|
A:POV1301
|
4.0
|
15.7
|
1.0
|
|
CD1
|
A:LEU977
|
4.1
|
33.5
|
1.0
|
|
CE2
|
A:TYR923
|
4.1
|
37.6
|
1.0
|
|
C38
|
A:POV1301
|
4.2
|
15.7
|
1.0
|
|
CZ
|
A:TYR923
|
4.2
|
37.6
|
1.0
|
|
HD11
|
A:LEU977
|
4.3
|
33.5
|
1.0
|
|
C39
|
A:POV1301
|
4.3
|
15.7
|
1.0
|
|
H33A
|
A:POV1301
|
4.3
|
15.7
|
1.0
|
|
O1
|
A:CLR1305
|
4.4
|
18.6
|
1.0
|
|
O32
|
A:POV1301
|
4.4
|
15.7
|
1.0
|
|
C35
|
A:POV1301
|
4.5
|
15.7
|
1.0
|
|
C34
|
A:POV1301
|
4.5
|
15.7
|
1.0
|
|
HZ
|
A:PHE924
|
4.5
|
36.7
|
1.0
|
|
H34
|
A:POV1301
|
4.6
|
15.7
|
1.0
|
|
C13
|
A:3FD1304
|
4.6
|
12.9
|
1.0
|
|
C36
|
A:POV1301
|
4.6
|
15.7
|
1.0
|
|
H32A
|
A:POV1301
|
4.7
|
15.7
|
1.0
|
|
C32
|
A:POV1301
|
4.7
|
15.7
|
1.0
|
|
C31
|
A:POV1301
|
4.7
|
15.7
|
1.0
|
|
HE1
|
A:PHE924
|
4.7
|
36.7
|
1.0
|
|
H39A
|
A:POV1301
|
4.7
|
15.7
|
1.0
|
|
CB
|
A:VAL974
|
4.7
|
32.8
|
1.0
|
|
H21
|
A:CLR1305
|
4.8
|
18.6
|
1.0
|
|
H14
|
A:3FD1304
|
4.9
|
12.9
|
1.0
|
|
H18
|
A:3FD1304
|
4.9
|
12.9
|
1.0
|
|
CD2
|
A:TYR923
|
4.9
|
37.6
|
1.0
|
|
H1
|
A:CLR1305
|
4.9
|
18.6
|
1.0
|
|
Chlorine binding site 2 out
of 8 in 8si7
Go back to
Chlorine Binding Sites List in 8si7
Chlorine binding site 2 out
of 8 in the Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl1304
b:12.9
occ:1.00
|
CL21
|
A:3FD1304
|
0.0
|
12.9
|
1.0
|
|
C15
|
A:3FD1304
|
1.8
|
12.9
|
1.0
|
|
C14
|
A:3FD1304
|
2.7
|
12.9
|
1.0
|
|
C16
|
A:3FD1304
|
2.7
|
12.9
|
1.0
|
|
H14
|
A:3FD1304
|
2.8
|
12.9
|
1.0
|
|
H35A
|
A:POV1301
|
2.8
|
15.7
|
1.0
|
|
HB
|
A:ILE993
|
2.9
|
28.4
|
1.0
|
|
HG21
|
A:ILE993
|
2.9
|
28.4
|
1.0
|
|
HG22
|
A:ILE993
|
3.2
|
28.4
|
1.0
|
|
CL20
|
A:3FD1304
|
3.2
|
12.9
|
1.0
|
|
HD12
|
A:ILE993
|
3.3
|
28.4
|
1.0
|
|
HD13
|
A:LEU977
|
3.3
|
33.5
|
1.0
|
|
CG2
|
A:ILE993
|
3.3
|
28.4
|
1.0
|
|
H37
|
A:POV1301
|
3.3
|
15.7
|
1.0
|
|
HD13
|
A:ILE993
|
3.5
|
28.4
|
1.0
|
|
CB
|
A:ILE993
|
3.5
|
28.4
|
1.0
|
|
H38A
|
A:POV1301
|
3.6
|
15.7
|
1.0
|
|
C35
|
A:POV1301
|
3.7
|
15.7
|
1.0
|
|
CD1
|
A:ILE993
|
3.8
|
28.4
|
1.0
|
|
H36A
|
A:POV1301
|
3.8
|
15.7
|
1.0
|
|
H33
|
A:POV1301
|
3.9
|
15.7
|
1.0
|
|
H32A
|
A:POV1301
|
3.9
|
15.7
|
1.0
|
|
CD1
|
A:LEU977
|
4.0
|
33.5
|
1.0
|
|
C37
|
A:POV1301
|
4.0
|
15.7
|
1.0
|
|
C17
|
A:3FD1304
|
4.0
|
12.9
|
1.0
|
|
C13
|
A:3FD1304
|
4.0
|
12.9
|
1.0
|
|
C36
|
A:POV1301
|
4.0
|
15.7
|
1.0
|
|
HD11
|
A:LEU977
|
4.0
|
33.5
|
1.0
|
|
HD12
|
A:LEU977
|
4.1
|
33.5
|
1.0
|
|
HG13
|
A:VAL990
|
4.1
|
31.6
|
1.0
|
|
O
|
A:VAL990
|
4.1
|
31.6
|
1.0
|
|
H35
|
A:POV1301
|
4.2
|
15.7
|
1.0
|
|
CG1
|
A:ILE993
|
4.2
|
28.4
|
1.0
|
|
HG23
|
A:ILE993
|
4.3
|
28.4
|
1.0
|
|
C38
|
A:POV1301
|
4.3
|
15.7
|
1.0
|
|
C33
|
A:POV1301
|
4.5
|
15.7
|
1.0
|
|
C18
|
A:3FD1304
|
4.5
|
12.9
|
1.0
|
|
C32
|
A:POV1301
|
4.6
|
15.7
|
1.0
|
|
H
|
A:GLY994
|
4.6
|
29.0
|
1.0
|
|
HD11
|
A:ILE993
|
4.6
|
28.4
|
1.0
|
|
C34
|
A:POV1301
|
4.7
|
15.7
|
1.0
|
|
HA
|
A:VAL990
|
4.7
|
31.6
|
1.0
|
|
CA
|
A:ILE993
|
4.8
|
28.4
|
1.0
|
|
HG12
|
A:ILE993
|
4.8
|
28.4
|
1.0
|
|
H37A
|
A:POV1301
|
4.8
|
15.7
|
1.0
|
|
H17
|
A:3FD1304
|
4.9
|
12.9
|
1.0
|
|
N
|
A:GLY994
|
4.9
|
29.0
|
1.0
|
|
HG13
|
A:ILE993
|
4.9
|
28.4
|
1.0
|
|
H39
|
A:POV1301
|
4.9
|
15.7
|
1.0
|
|
HG12
|
A:VAL990
|
4.9
|
31.6
|
1.0
|
|
CG1
|
A:VAL990
|
4.9
|
31.6
|
1.0
|
|
C31
|
A:POV1301
|
4.9
|
15.7
|
1.0
|
|
H38
|
A:POV1301
|
5.0
|
15.7
|
1.0
|
|
Chlorine binding site 3 out
of 8 in 8si7
Go back to
Chlorine Binding Sites List in 8si7
Chlorine binding site 3 out
of 8 in the Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl1305
b:21.3
occ:1.00
|
CL20
|
B:3FD1305
|
0.0
|
21.3
|
1.0
|
|
C16
|
B:3FD1305
|
1.8
|
21.3
|
1.0
|
|
C17
|
B:3FD1305
|
2.7
|
21.3
|
1.0
|
|
C15
|
B:3FD1305
|
2.8
|
21.3
|
1.0
|
|
H37
|
B:POV1302
|
2.8
|
24.8
|
1.0
|
|
H17
|
B:3FD1305
|
2.8
|
21.3
|
1.0
|
|
H33
|
B:POV1302
|
2.9
|
24.8
|
1.0
|
|
HG13
|
B:VAL974
|
3.0
|
14.9
|
1.0
|
|
HG11
|
B:VAL974
|
3.0
|
14.9
|
1.0
|
|
CL21
|
B:3FD1305
|
3.2
|
21.3
|
1.0
|
|
CG1
|
B:VAL974
|
3.3
|
14.9
|
1.0
|
|
HG12
|
B:VAL974
|
3.3
|
14.9
|
1.0
|
|
HD12
|
B:LEU977
|
3.4
|
13.3
|
1.0
|
|
H39
|
B:POV1302
|
3.5
|
24.8
|
1.0
|
|
HH
|
B:TYR923
|
3.7
|
22.0
|
1.0
|
|
C37
|
B:POV1302
|
3.7
|
24.8
|
1.0
|
|
H35A
|
B:POV1302
|
3.9
|
24.8
|
1.0
|
|
C33
|
B:POV1302
|
3.9
|
24.8
|
1.0
|
|
HE2
|
B:TYR923
|
3.9
|
22.0
|
1.0
|
|
HD13
|
B:LEU977
|
4.0
|
13.3
|
1.0
|
|
C14
|
B:3FD1305
|
4.0
|
21.3
|
1.0
|
|
H38A
|
B:POV1302
|
4.0
|
24.8
|
1.0
|
|
OH
|
B:TYR923
|
4.0
|
22.0
|
1.0
|
|
H37A
|
B:POV1302
|
4.0
|
24.8
|
1.0
|
|
C18
|
B:3FD1305
|
4.0
|
21.3
|
1.0
|
|
CD1
|
B:LEU977
|
4.1
|
13.3
|
1.0
|
|
CE2
|
B:TYR923
|
4.1
|
22.0
|
1.0
|
|
C38
|
B:POV1302
|
4.2
|
24.8
|
1.0
|
|
CZ
|
B:TYR923
|
4.2
|
22.0
|
1.0
|
|
HD11
|
B:LEU977
|
4.3
|
13.3
|
1.0
|
|
C39
|
B:POV1302
|
4.3
|
24.8
|
1.0
|
|
H33A
|
B:POV1302
|
4.3
|
24.8
|
1.0
|
|
O32
|
B:POV1302
|
4.4
|
24.8
|
1.0
|
|
O1
|
B:CLR1306
|
4.4
|
27.6
|
1.0
|
|
C35
|
B:POV1302
|
4.5
|
24.8
|
1.0
|
|
C34
|
B:POV1302
|
4.5
|
24.8
|
1.0
|
|
HZ
|
B:PHE924
|
4.5
|
17.4
|
1.0
|
|
H34
|
B:POV1302
|
4.6
|
24.8
|
1.0
|
|
C13
|
B:3FD1305
|
4.6
|
21.3
|
1.0
|
|
C36
|
B:POV1302
|
4.6
|
24.8
|
1.0
|
|
H32A
|
B:POV1302
|
4.7
|
24.8
|
1.0
|
|
C32
|
B:POV1302
|
4.7
|
24.8
|
1.0
|
|
C31
|
B:POV1302
|
4.7
|
24.8
|
1.0
|
|
HE1
|
B:PHE924
|
4.7
|
17.4
|
1.0
|
|
H39A
|
B:POV1302
|
4.7
|
24.8
|
1.0
|
|
CB
|
B:VAL974
|
4.7
|
14.9
|
1.0
|
|
H21
|
B:CLR1306
|
4.8
|
27.6
|
1.0
|
|
H14
|
B:3FD1305
|
4.9
|
21.3
|
1.0
|
|
H18
|
B:3FD1305
|
4.9
|
21.3
|
1.0
|
|
CD2
|
B:TYR923
|
4.9
|
22.0
|
1.0
|
|
H1
|
B:CLR1306
|
4.9
|
27.6
|
1.0
|
|
Chlorine binding site 4 out
of 8 in 8si7
Go back to
Chlorine Binding Sites List in 8si7
Chlorine binding site 4 out
of 8 in the Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl1305
b:21.3
occ:1.00
|
CL21
|
B:3FD1305
|
0.0
|
21.3
|
1.0
|
|
C15
|
B:3FD1305
|
1.8
|
21.3
|
1.0
|
|
C14
|
B:3FD1305
|
2.7
|
21.3
|
1.0
|
|
C16
|
B:3FD1305
|
2.7
|
21.3
|
1.0
|
|
H14
|
B:3FD1305
|
2.8
|
21.3
|
1.0
|
|
H35A
|
B:POV1302
|
2.8
|
24.8
|
1.0
|
|
HB
|
B:ILE993
|
2.9
|
24.1
|
1.0
|
|
HG21
|
B:ILE993
|
2.9
|
24.1
|
1.0
|
|
HG22
|
B:ILE993
|
3.2
|
24.1
|
1.0
|
|
CL20
|
B:3FD1305
|
3.2
|
21.3
|
1.0
|
|
HD12
|
B:ILE993
|
3.3
|
24.1
|
1.0
|
|
HD13
|
B:LEU977
|
3.3
|
13.3
|
1.0
|
|
CG2
|
B:ILE993
|
3.3
|
24.1
|
1.0
|
|
H37
|
B:POV1302
|
3.4
|
24.8
|
1.0
|
|
HD13
|
B:ILE993
|
3.5
|
24.1
|
1.0
|
|
CB
|
B:ILE993
|
3.5
|
24.1
|
1.0
|
|
H38A
|
B:POV1302
|
3.6
|
24.8
|
1.0
|
|
C35
|
B:POV1302
|
3.7
|
24.8
|
1.0
|
|
CD1
|
B:ILE993
|
3.8
|
24.1
|
1.0
|
|
H36A
|
B:POV1302
|
3.8
|
24.8
|
1.0
|
|
H33
|
B:POV1302
|
3.9
|
24.8
|
1.0
|
|
H32A
|
B:POV1302
|
3.9
|
24.8
|
1.0
|
|
CD1
|
B:LEU977
|
4.0
|
13.3
|
1.0
|
|
C37
|
B:POV1302
|
4.0
|
24.8
|
1.0
|
|
C17
|
B:3FD1305
|
4.0
|
21.3
|
1.0
|
|
C13
|
B:3FD1305
|
4.0
|
21.3
|
1.0
|
|
C36
|
B:POV1302
|
4.0
|
24.8
|
1.0
|
|
HD11
|
B:LEU977
|
4.1
|
13.3
|
1.0
|
|
HD12
|
B:LEU977
|
4.1
|
13.3
|
1.0
|
|
HG13
|
B:VAL990
|
4.1
|
20.4
|
1.0
|
|
O
|
B:VAL990
|
4.1
|
20.4
|
1.0
|
|
H35
|
B:POV1302
|
4.2
|
24.8
|
1.0
|
|
CG1
|
B:ILE993
|
4.2
|
24.1
|
1.0
|
|
HG23
|
B:ILE993
|
4.3
|
24.1
|
1.0
|
|
C38
|
B:POV1302
|
4.3
|
24.8
|
1.0
|
|
C33
|
B:POV1302
|
4.5
|
24.8
|
1.0
|
|
C18
|
B:3FD1305
|
4.5
|
21.3
|
1.0
|
|
C32
|
B:POV1302
|
4.6
|
24.8
|
1.0
|
|
H
|
B:GLY994
|
4.6
|
10.4
|
1.0
|
|
HD11
|
B:ILE993
|
4.6
|
24.1
|
1.0
|
|
C34
|
B:POV1302
|
4.7
|
24.8
|
1.0
|
|
HA
|
B:VAL990
|
4.7
|
20.4
|
1.0
|
|
CA
|
B:ILE993
|
4.8
|
24.1
|
1.0
|
|
HG12
|
B:ILE993
|
4.8
|
24.1
|
1.0
|
|
H37A
|
B:POV1302
|
4.9
|
24.8
|
1.0
|
|
H17
|
B:3FD1305
|
4.9
|
21.3
|
1.0
|
|
N
|
B:GLY994
|
4.9
|
10.4
|
1.0
|
|
HG13
|
B:ILE993
|
4.9
|
24.1
|
1.0
|
|
HG12
|
B:VAL990
|
4.9
|
20.4
|
1.0
|
|
H39
|
B:POV1302
|
4.9
|
24.8
|
1.0
|
|
CG1
|
B:VAL990
|
4.9
|
20.4
|
1.0
|
|
C31
|
B:POV1302
|
4.9
|
24.8
|
1.0
|
|
H38
|
B:POV1302
|
5.0
|
24.8
|
1.0
|
|
Chlorine binding site 5 out
of 8 in 8si7
Go back to
Chlorine Binding Sites List in 8si7
Chlorine binding site 5 out
of 8 in the Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Cl1305
b:19.9
occ:1.00
|
CL20
|
C:3FD1305
|
0.0
|
19.9
|
1.0
|
|
C16
|
C:3FD1305
|
1.8
|
19.9
|
1.0
|
|
C17
|
C:3FD1305
|
2.7
|
19.9
|
1.0
|
|
C15
|
C:3FD1305
|
2.8
|
19.9
|
1.0
|
|
H37
|
C:POV1302
|
2.8
|
23.6
|
1.0
|
|
H17
|
C:3FD1305
|
2.9
|
19.9
|
1.0
|
|
H33
|
C:POV1302
|
2.9
|
23.6
|
1.0
|
|
HG13
|
C:VAL974
|
3.0
|
21.5
|
1.0
|
|
HG11
|
C:VAL974
|
3.0
|
21.5
|
1.0
|
|
CL21
|
C:3FD1305
|
3.2
|
19.9
|
1.0
|
|
CG1
|
C:VAL974
|
3.3
|
21.5
|
1.0
|
|
HG12
|
C:VAL974
|
3.3
|
21.5
|
1.0
|
|
HD12
|
C:LEU977
|
3.4
|
19.8
|
1.0
|
|
H39
|
C:POV1302
|
3.5
|
23.6
|
1.0
|
|
HH
|
C:TYR923
|
3.7
|
25.8
|
1.0
|
|
C37
|
C:POV1302
|
3.7
|
23.6
|
1.0
|
|
H35A
|
C:POV1302
|
3.8
|
23.6
|
1.0
|
|
C33
|
C:POV1302
|
3.9
|
23.6
|
1.0
|
|
HE2
|
C:TYR923
|
3.9
|
25.8
|
1.0
|
|
HD13
|
C:LEU977
|
4.0
|
19.8
|
1.0
|
|
C14
|
C:3FD1305
|
4.0
|
19.9
|
1.0
|
|
OH
|
C:TYR923
|
4.0
|
25.8
|
1.0
|
|
C18
|
C:3FD1305
|
4.0
|
19.9
|
1.0
|
|
H37A
|
C:POV1302
|
4.0
|
23.6
|
1.0
|
|
H38A
|
C:POV1302
|
4.1
|
23.6
|
1.0
|
|
CD1
|
C:LEU977
|
4.1
|
19.8
|
1.0
|
|
CE2
|
C:TYR923
|
4.1
|
25.8
|
1.0
|
|
C38
|
C:POV1302
|
4.2
|
23.6
|
1.0
|
|
CZ
|
C:TYR923
|
4.2
|
25.8
|
1.0
|
|
HD11
|
C:LEU977
|
4.3
|
19.8
|
1.0
|
|
C39
|
C:POV1302
|
4.3
|
23.6
|
1.0
|
|
H33A
|
C:POV1302
|
4.3
|
23.6
|
1.0
|
|
O1
|
C:CLR1306
|
4.4
|
26.7
|
1.0
|
|
O32
|
C:POV1302
|
4.5
|
23.6
|
1.0
|
|
C35
|
C:POV1302
|
4.5
|
23.6
|
1.0
|
|
C34
|
C:POV1302
|
4.5
|
23.6
|
1.0
|
|
H34
|
C:POV1302
|
4.5
|
23.6
|
1.0
|
|
HZ
|
C:PHE924
|
4.6
|
22.4
|
1.0
|
|
C13
|
C:3FD1305
|
4.6
|
19.9
|
1.0
|
|
C36
|
C:POV1302
|
4.6
|
23.6
|
1.0
|
|
H32A
|
C:POV1302
|
4.7
|
23.6
|
1.0
|
|
C32
|
C:POV1302
|
4.7
|
23.6
|
1.0
|
|
C31
|
C:POV1302
|
4.7
|
23.6
|
1.0
|
|
HE1
|
C:PHE924
|
4.7
|
22.4
|
1.0
|
|
H39A
|
C:POV1302
|
4.7
|
23.6
|
1.0
|
|
CB
|
C:VAL974
|
4.7
|
21.5
|
1.0
|
|
H21
|
C:CLR1306
|
4.8
|
26.7
|
1.0
|
|
H14
|
C:3FD1305
|
4.9
|
19.9
|
1.0
|
|
H18
|
C:3FD1305
|
4.9
|
19.9
|
1.0
|
|
H1
|
C:CLR1306
|
4.9
|
26.7
|
1.0
|
|
CD2
|
C:TYR923
|
4.9
|
25.8
|
1.0
|
|
Chlorine binding site 6 out
of 8 in 8si7
Go back to
Chlorine Binding Sites List in 8si7
Chlorine binding site 6 out
of 8 in the Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Cl1305
b:19.9
occ:1.00
|
CL21
|
C:3FD1305
|
0.0
|
19.9
|
1.0
|
|
C15
|
C:3FD1305
|
1.8
|
19.9
|
1.0
|
|
C14
|
C:3FD1305
|
2.7
|
19.9
|
1.0
|
|
C16
|
C:3FD1305
|
2.7
|
19.9
|
1.0
|
|
H14
|
C:3FD1305
|
2.8
|
19.9
|
1.0
|
|
H35A
|
C:POV1302
|
2.8
|
23.6
|
1.0
|
|
HG21
|
C:ILE993
|
2.9
|
19.9
|
1.0
|
|
HB
|
C:ILE993
|
2.9
|
19.9
|
1.0
|
|
HG22
|
C:ILE993
|
3.1
|
19.9
|
1.0
|
|
CL20
|
C:3FD1305
|
3.2
|
19.9
|
1.0
|
|
HD12
|
C:ILE993
|
3.3
|
19.9
|
1.0
|
|
HD13
|
C:LEU977
|
3.3
|
19.8
|
1.0
|
|
CG2
|
C:ILE993
|
3.3
|
19.9
|
1.0
|
|
H37
|
C:POV1302
|
3.4
|
23.6
|
1.0
|
|
HD13
|
C:ILE993
|
3.5
|
19.9
|
1.0
|
|
CB
|
C:ILE993
|
3.5
|
19.9
|
1.0
|
|
H38A
|
C:POV1302
|
3.6
|
23.6
|
1.0
|
|
C35
|
C:POV1302
|
3.7
|
23.6
|
1.0
|
|
CD1
|
C:ILE993
|
3.8
|
19.9
|
1.0
|
|
H36A
|
C:POV1302
|
3.8
|
23.6
|
1.0
|
|
H33
|
C:POV1302
|
3.9
|
23.6
|
1.0
|
|
H32A
|
C:POV1302
|
3.9
|
23.6
|
1.0
|
|
CD1
|
C:LEU977
|
4.0
|
19.8
|
1.0
|
|
C37
|
C:POV1302
|
4.0
|
23.6
|
1.0
|
|
C17
|
C:3FD1305
|
4.0
|
19.9
|
1.0
|
|
C13
|
C:3FD1305
|
4.0
|
19.9
|
1.0
|
|
C36
|
C:POV1302
|
4.0
|
23.6
|
1.0
|
|
HD11
|
C:LEU977
|
4.0
|
19.8
|
1.0
|
|
HD12
|
C:LEU977
|
4.1
|
19.8
|
1.0
|
|
HG13
|
C:VAL990
|
4.1
|
17.6
|
1.0
|
|
O
|
C:VAL990
|
4.2
|
17.6
|
1.0
|
|
H35
|
C:POV1302
|
4.2
|
23.6
|
1.0
|
|
CG1
|
C:ILE993
|
4.2
|
19.9
|
1.0
|
|
HG23
|
C:ILE993
|
4.3
|
19.9
|
1.0
|
|
C38
|
C:POV1302
|
4.3
|
23.6
|
1.0
|
|
C33
|
C:POV1302
|
4.5
|
23.6
|
1.0
|
|
C18
|
C:3FD1305
|
4.5
|
19.9
|
1.0
|
|
C32
|
C:POV1302
|
4.6
|
23.6
|
1.0
|
|
H
|
C:GLY994
|
4.6
|
21.9
|
1.0
|
|
HD11
|
C:ILE993
|
4.6
|
19.9
|
1.0
|
|
C34
|
C:POV1302
|
4.7
|
23.6
|
1.0
|
|
HA
|
C:VAL990
|
4.7
|
17.6
|
1.0
|
|
CA
|
C:ILE993
|
4.8
|
19.9
|
1.0
|
|
HG12
|
C:ILE993
|
4.8
|
19.9
|
1.0
|
|
H17
|
C:3FD1305
|
4.9
|
19.9
|
1.0
|
|
H37A
|
C:POV1302
|
4.9
|
23.6
|
1.0
|
|
HG13
|
C:ILE993
|
4.9
|
19.9
|
1.0
|
|
N
|
C:GLY994
|
4.9
|
21.9
|
1.0
|
|
H39
|
C:POV1302
|
4.9
|
23.6
|
1.0
|
|
HG12
|
C:VAL990
|
4.9
|
17.6
|
1.0
|
|
CG1
|
C:VAL990
|
4.9
|
17.6
|
1.0
|
|
C31
|
C:POV1302
|
4.9
|
23.6
|
1.0
|
|
H38
|
C:POV1302
|
5.0
|
23.6
|
1.0
|
|
Chlorine binding site 7 out
of 8 in 8si7
Go back to
Chlorine Binding Sites List in 8si7
Chlorine binding site 7 out
of 8 in the Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 7 of Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Cl1306
b:20.4
occ:1.00
|
CL20
|
D:3FD1306
|
0.0
|
20.4
|
1.0
|
|
C16
|
D:3FD1306
|
1.8
|
20.4
|
1.0
|
|
C17
|
D:3FD1306
|
2.7
|
20.4
|
1.0
|
|
C15
|
D:3FD1306
|
2.8
|
20.4
|
1.0
|
|
H37
|
D:POV1304
|
2.8
|
23.9
|
1.0
|
|
H17
|
D:3FD1306
|
2.8
|
20.4
|
1.0
|
|
H33
|
D:POV1304
|
2.9
|
23.9
|
1.0
|
|
HG13
|
D:VAL974
|
3.0
|
32.5
|
1.0
|
|
HG11
|
D:VAL974
|
3.0
|
32.5
|
1.0
|
|
CL21
|
D:3FD1306
|
3.2
|
20.4
|
1.0
|
|
CG1
|
D:VAL974
|
3.3
|
32.5
|
1.0
|
|
HG12
|
D:VAL974
|
3.3
|
32.5
|
1.0
|
|
HD12
|
D:LEU977
|
3.4
|
32.3
|
1.0
|
|
H39
|
D:POV1304
|
3.5
|
23.9
|
1.0
|
|
HH
|
D:TYR923
|
3.6
|
37.2
|
1.0
|
|
C37
|
D:POV1304
|
3.7
|
23.9
|
1.0
|
|
H35A
|
D:POV1304
|
3.9
|
23.9
|
1.0
|
|
C33
|
D:POV1304
|
3.9
|
23.9
|
1.0
|
|
HE2
|
D:TYR923
|
3.9
|
37.2
|
1.0
|
|
HD13
|
D:LEU977
|
4.0
|
32.3
|
1.0
|
|
C14
|
D:3FD1306
|
4.0
|
20.4
|
1.0
|
|
OH
|
D:TYR923
|
4.0
|
37.2
|
1.0
|
|
H38A
|
D:POV1304
|
4.0
|
23.9
|
1.0
|
|
C18
|
D:3FD1306
|
4.0
|
20.4
|
1.0
|
|
H37A
|
D:POV1304
|
4.0
|
23.9
|
1.0
|
|
CD1
|
D:LEU977
|
4.1
|
32.3
|
1.0
|
|
CE2
|
D:TYR923
|
4.1
|
37.2
|
1.0
|
|
C38
|
D:POV1304
|
4.2
|
23.9
|
1.0
|
|
CZ
|
D:TYR923
|
4.2
|
37.2
|
1.0
|
|
HD11
|
D:LEU977
|
4.3
|
32.3
|
1.0
|
|
C39
|
D:POV1304
|
4.3
|
23.9
|
1.0
|
|
H33A
|
D:POV1304
|
4.3
|
23.9
|
1.0
|
|
O1
|
D:CLR1307
|
4.4
|
26.9
|
1.0
|
|
O32
|
D:POV1304
|
4.5
|
23.9
|
1.0
|
|
C35
|
D:POV1304
|
4.5
|
23.9
|
1.0
|
|
C34
|
D:POV1304
|
4.5
|
23.9
|
1.0
|
|
HZ
|
D:PHE924
|
4.5
|
35.8
|
1.0
|
|
H34
|
D:POV1304
|
4.5
|
23.9
|
1.0
|
|
C13
|
D:3FD1306
|
4.6
|
20.4
|
1.0
|
|
C36
|
D:POV1304
|
4.6
|
23.9
|
1.0
|
|
H32A
|
D:POV1304
|
4.7
|
23.9
|
1.0
|
|
C32
|
D:POV1304
|
4.7
|
23.9
|
1.0
|
|
HE1
|
D:PHE924
|
4.7
|
35.8
|
1.0
|
|
C31
|
D:POV1304
|
4.7
|
23.9
|
1.0
|
|
H39A
|
D:POV1304
|
4.7
|
23.9
|
1.0
|
|
CB
|
D:VAL974
|
4.7
|
32.5
|
1.0
|
|
H21
|
D:CLR1307
|
4.8
|
26.9
|
1.0
|
|
H14
|
D:3FD1306
|
4.9
|
20.4
|
1.0
|
|
H18
|
D:3FD1306
|
4.9
|
20.4
|
1.0
|
|
CD2
|
D:TYR923
|
4.9
|
37.2
|
1.0
|
|
H1
|
D:CLR1307
|
4.9
|
26.9
|
1.0
|
|
Chlorine binding site 8 out
of 8 in 8si7
Go back to
Chlorine Binding Sites List in 8si7
Chlorine binding site 8 out
of 8 in the Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 8 of Cryo-Em Structure of TRPM7 in Gdn Detergent in Complex with Inhibitor VER155008 in Closed State within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Cl1306
b:20.4
occ:1.00
|
CL21
|
D:3FD1306
|
0.0
|
20.4
|
1.0
|
|
C15
|
D:3FD1306
|
1.8
|
20.4
|
1.0
|
|
C14
|
D:3FD1306
|
2.7
|
20.4
|
1.0
|
|
C16
|
D:3FD1306
|
2.7
|
20.4
|
1.0
|
|
H14
|
D:3FD1306
|
2.8
|
20.4
|
1.0
|
|
H35A
|
D:POV1304
|
2.8
|
23.9
|
1.0
|
|
HB
|
D:ILE993
|
2.9
|
29.7
|
1.0
|
|
HG21
|
D:ILE993
|
2.9
|
29.7
|
1.0
|
|
HG22
|
D:ILE993
|
3.2
|
29.7
|
1.0
|
|
CL20
|
D:3FD1306
|
3.2
|
20.4
|
1.0
|
|
HD12
|
D:ILE993
|
3.3
|
29.7
|
1.0
|
|
HD13
|
D:LEU977
|
3.3
|
32.3
|
1.0
|
|
CG2
|
D:ILE993
|
3.3
|
29.7
|
1.0
|
|
H37
|
D:POV1304
|
3.4
|
23.9
|
1.0
|
|
HD13
|
D:ILE993
|
3.5
|
29.7
|
1.0
|
|
CB
|
D:ILE993
|
3.5
|
29.7
|
1.0
|
|
H38A
|
D:POV1304
|
3.6
|
23.9
|
1.0
|
|
C35
|
D:POV1304
|
3.7
|
23.9
|
1.0
|
|
CD1
|
D:ILE993
|
3.8
|
29.7
|
1.0
|
|
H36A
|
D:POV1304
|
3.8
|
23.9
|
1.0
|
|
H33
|
D:POV1304
|
3.9
|
23.9
|
1.0
|
|
H32A
|
D:POV1304
|
3.9
|
23.9
|
1.0
|
|
CD1
|
D:LEU977
|
4.0
|
32.3
|
1.0
|
|
C37
|
D:POV1304
|
4.0
|
23.9
|
1.0
|
|
C17
|
D:3FD1306
|
4.0
|
20.4
|
1.0
|
|
C13
|
D:3FD1306
|
4.0
|
20.4
|
1.0
|
|
C36
|
D:POV1304
|
4.0
|
23.9
|
1.0
|
|
HD11
|
D:LEU977
|
4.1
|
32.3
|
1.0
|
|
HD12
|
D:LEU977
|
4.1
|
32.3
|
1.0
|
|
HG13
|
D:VAL990
|
4.1
|
31.9
|
1.0
|
|
O
|
D:VAL990
|
4.1
|
31.9
|
1.0
|
|
H35
|
D:POV1304
|
4.2
|
23.9
|
1.0
|
|
CG1
|
D:ILE993
|
4.2
|
29.7
|
1.0
|
|
HG23
|
D:ILE993
|
4.3
|
29.7
|
1.0
|
|
C38
|
D:POV1304
|
4.3
|
23.9
|
1.0
|
|
C33
|
D:POV1304
|
4.5
|
23.9
|
1.0
|
|
C18
|
D:3FD1306
|
4.5
|
20.4
|
1.0
|
|
C32
|
D:POV1304
|
4.6
|
23.9
|
1.0
|
|
H
|
D:GLY994
|
4.6
|
28.3
|
1.0
|
|
HD11
|
D:ILE993
|
4.6
|
29.7
|
1.0
|
|
C34
|
D:POV1304
|
4.7
|
23.9
|
1.0
|
|
HA
|
D:VAL990
|
4.7
|
31.9
|
1.0
|
|
CA
|
D:ILE993
|
4.8
|
29.7
|
1.0
|
|
HG12
|
D:ILE993
|
4.8
|
29.7
|
1.0
|
|
H17
|
D:3FD1306
|
4.9
|
20.4
|
1.0
|
|
H37A
|
D:POV1304
|
4.9
|
23.9
|
1.0
|
|
N
|
D:GLY994
|
4.9
|
28.3
|
1.0
|
|
HG13
|
D:ILE993
|
4.9
|
29.7
|
1.0
|
|
HG12
|
D:VAL990
|
4.9
|
31.9
|
1.0
|
|
H39
|
D:POV1304
|
4.9
|
23.9
|
1.0
|
|
CG1
|
D:VAL990
|
4.9
|
31.9
|
1.0
|
|
C31
|
D:POV1304
|
4.9
|
23.9
|
1.0
|
|
H38
|
D:POV1304
|
5.0
|
23.9
|
1.0
|
|
Reference:
K.D.Nadezhdin,
L.Correia,
C.Narangoda,
D.S.Patel,
A.Neuberger,
T.Gudermann,
M.G.Kurnikova,
V.Chubanov,
A.I.Sobolevsky.
Structural Mechanisms of TRPM7 Activation and Inhibition Nat Commun.
ISSN: ESSN 2041-1723
Page generated: Wed Jul 26 17:16:50 2023
|
