Chlorine in PDB 8sij: Crystal Structure of F. Varium Tryptophanase

The structure of Crystal Structure of F. Varium Tryptophanase, PDB code: 8sij was solved by A.L.Graboski, M.R.Redinbo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.54 / 2.60
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	98.589, 98.589, 278.515, 90, 90, 90
R / Rfree (%)	24 / 26

The binding sites of Chlorine atom in the Crystal Structure of F. Varium Tryptophanase (pdb code 8sij). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of F. Varium Tryptophanase, PDB code: 8sij:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of F. Varium Tryptophanase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of F. Varium Tryptophanase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl502 b:71.8 occ:1.00 O A:GLY54 3.2 64.5 1.0 O A:ASN264 3.8 66.0 1.0 C A:GLY54 4.1 64.0 1.0 CA A:GLY54 4.6 64.6 1.0 O A:SER53 4.7 67.1 1.0 CG2 A:THR55 4.8 63.0 1.0 C A:ASN264 4.9 64.8 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of F. Varium Tryptophanase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of F. Varium Tryptophanase within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl502 b:64.2 occ:1.00 O B:GLY54 3.5 57.8 1.0 O B:ASN264 4.2 59.4 1.0 C B:GLY54 4.3 57.8 1.0 CA B:GLY54 4.7 59.2 1.0 CB B:ASN264 4.9 55.6 1.0

A.L.Graboski, M.R.Redinbo. Mechanism-Based Inhibition of Gut Microbial Tryptophanases Reduces Serum Indoxyl Sulfate Cell Chem Biol 2023.
ISSN: ESSN 2451-9456
DOI: 10.1016/J.CHEMBIOL.2023.07.015