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Atomistry » Chlorine » PDB 8sbx-8sxr » 8siv | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 8sbx-8sxr » 8siv » |
Chlorine in PDB 8siv: Structure of Compound 2 Bound to the CHK1 10-Point MutantEnzymatic activity of Structure of Compound 2 Bound to the CHK1 10-Point Mutant
All present enzymatic activity of Structure of Compound 2 Bound to the CHK1 10-Point Mutant:
2.7.11.1; Protein crystallography data
The structure of Structure of Compound 2 Bound to the CHK1 10-Point Mutant, PDB code: 8siv
was solved by
R.L.Palte,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of Compound 2 Bound to the CHK1 10-Point Mutant
(pdb code 8siv). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Compound 2 Bound to the CHK1 10-Point Mutant, PDB code: 8siv: Chlorine binding site 1 out of 1 in 8sivGo back to Chlorine Binding Sites List in 8siv
Chlorine binding site 1 out
of 1 in the Structure of Compound 2 Bound to the CHK1 10-Point Mutant
Mono view Stereo pair view
Reference:
S.D.Kattar,
A.Gulati,
K.A.Margrey,
M.H.Keylor,
M.Ardolino,
X.Yan,
R.Johnson,
R.L.Palte,
S.E.Mcminn,
L.Nogle,
J.Su,
D.Xiao,
J.Piesvaux,
S.Lee,
L.G.Hegde,
J.D.Woodhouse,
R.Faltus,
L.Y.Moy,
T.Xiong,
P.J.Ciaccio,
K.Pearson,
M.Patel,
K.M.Otte,
C.E.G.Leyns,
M.E.Kennedy,
D.J.Bennett,
E.F.Dimauro,
M.J.Fell,
P.H.Fuller.
Discovery of Mk-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor For the Potential Treatment of Parkinson'S Disease. J.Med.Chem. 2023.
Page generated: Thu Dec 28 03:29:45 2023
ISSN: ISSN 0022-2623 PubMed: 37861679 DOI: 10.1021/ACS.JMEDCHEM.3C01486 |
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