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Atomistry » Chlorine » PDB 8sbx-8sxr » 8siw | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 8sbx-8sxr » 8siw » |
Chlorine in PDB 8siw: Structure of Compound 5 Bound to the CHK1 10-Point MutantEnzymatic activity of Structure of Compound 5 Bound to the CHK1 10-Point Mutant
All present enzymatic activity of Structure of Compound 5 Bound to the CHK1 10-Point Mutant:
2.7.11.1; Protein crystallography data
The structure of Structure of Compound 5 Bound to the CHK1 10-Point Mutant, PDB code: 8siw
was solved by
R.L.Palte,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of Compound 5 Bound to the CHK1 10-Point Mutant
(pdb code 8siw). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of Compound 5 Bound to the CHK1 10-Point Mutant, PDB code: 8siw: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 8siwGo back to Chlorine Binding Sites List in 8siw
Chlorine binding site 1 out
of 2 in the Structure of Compound 5 Bound to the CHK1 10-Point Mutant
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 8siwGo back to Chlorine Binding Sites List in 8siw
Chlorine binding site 2 out
of 2 in the Structure of Compound 5 Bound to the CHK1 10-Point Mutant
Mono view Stereo pair view
Reference:
S.D.Kattar,
A.Gulati,
K.A.Margrey,
M.H.Keylor,
M.Ardolino,
X.Yan,
R.Johnson,
R.L.Palte,
S.E.Mcminn,
L.Nogle,
J.Su,
D.Xiao,
J.Piesvaux,
S.Lee,
L.G.Hegde,
J.D.Woodhouse,
R.Faltus,
L.Y.Moy,
T.Xiong,
P.J.Ciaccio,
K.Pearson,
M.Patel,
K.M.Otte,
C.E.G.Leyns,
M.E.Kennedy,
D.J.Bennett,
E.F.Dimauro,
M.J.Fell,
P.H.Fuller.
Discovery of Mk-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor For the Potential Treatment of Parkinson'S Disease. J.Med.Chem. 2023.
Page generated: Thu Dec 28 03:29:45 2023
ISSN: ISSN 0022-2623 PubMed: 37861679 DOI: 10.1021/ACS.JMEDCHEM.3C01486 |
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