Chlorine in PDB 8sp8: Human Trp Channel TRPV6 in CNW30 Nanodiscs Inhibited By Tetrahydrocannabivarin (Thcv)

The structure of Human Trp Channel TRPV6 in CNW30 Nanodiscs Inhibited By Tetrahydrocannabivarin (Thcv) also contains other interesting chemical elements:

Calcium

(Ca)

1 atom

The binding sites of Chlorine atom in the Human Trp Channel TRPV6 in CNW30 Nanodiscs Inhibited By Tetrahydrocannabivarin (Thcv) (pdb code 8sp8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Trp Channel TRPV6 in CNW30 Nanodiscs Inhibited By Tetrahydrocannabivarin (Thcv), PDB code: 8sp8:

Chlorine binding site 1 out of 1 in the Human Trp Channel TRPV6 in CNW30 Nanodiscs Inhibited By Tetrahydrocannabivarin (Thcv)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Trp Channel TRPV6 in CNW30 Nanodiscs Inhibited By Tetrahydrocannabivarin (Thcv) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl814 b:67.3 occ:1.00 HD21 C:LEU574 2.6 81.3 1.0 HD21 D:LEU574 2.6 81.5 1.0 HD21 A:LEU574 2.6 82.1 1.0 HD21 B:LEU574 2.6 78.2 1.0 HE1 B:MET578 2.7 94.0 1.0 HE1 D:MET578 2.7 97.6 1.0 HE1 A:MET578 2.7 98.2 1.0 HE1 C:MET578 2.7 97.5 1.0 CD2 C:LEU574 3.5 81.3 1.0 CD2 A:LEU574 3.5 82.1 1.0 CD2 D:LEU574 3.5 81.5 1.0 CE A:MET578 3.5 98.2 1.0 CD2 B:LEU574 3.5 78.2 1.0 CE D:MET578 3.5 97.6 1.0 CE B:MET578 3.5 94.0 1.0 CE C:MET578 3.5 97.5 1.0 HE3 A:MET578 3.7 98.2 1.0 HE3 C:MET578 3.7 97.5 1.0 HE3 D:MET578 3.7 97.6 1.0 HE3 B:MET578 3.7 94.0 1.0 HD22 A:LEU574 3.7 82.1 1.0 HD22 C:LEU574 3.7 81.3 1.0 HE2 D:MET578 3.7 97.6 1.0 HD22 D:LEU574 3.7 81.5 1.0 HE2 A:MET578 3.7 98.2 1.0 HE2 B:MET578 3.7 94.0 1.0 HD22 B:LEU574 3.7 78.2 1.0 HE2 C:MET578 3.7 97.5 1.0 HD23 A:LEU574 3.8 82.1 1.0 HD23 C:LEU574 3.8 81.3 1.0 HD23 D:LEU574 3.8 81.5 1.0 HD23 B:LEU574 3.8 78.2 1.0 HD11 C:LEU574 4.0 81.3 1.0 HD11 B:LEU574 4.0 78.2 1.0 HD11 D:LEU574 4.0 81.5 1.0 HD11 A:LEU574 4.0 82.1 1.0 CG C:LEU574 4.6 81.3 1.0 CG D:LEU574 4.6 81.5 1.0 CG B:LEU574 4.6 78.2 1.0 CG A:LEU574 4.6 82.1 1.0 CD1 C:LEU574 4.6 81.3 1.0 CD1 A:LEU574 4.6 82.1 1.0 CD1 D:LEU574 4.6 81.5 1.0 CD1 B:LEU574 4.6 78.2 1.0 HD13 C:LEU574 4.7 81.3 1.0 HD13 A:LEU574 4.7 82.1 1.0 HD13 D:LEU574 4.7 81.5 1.0 HG C:LEU574 4.7 81.3 1.0 HG B:LEU574 4.7 78.2 1.0 HD13 B:LEU574 4.7 78.2 1.0 HG D:LEU574 4.7 81.5 1.0 HG A:LEU574 4.7 82.1 1.0 SD A:MET578 5.0 98.2 1.0 SD D:MET578 5.0 97.6 1.0 SD B:MET578 5.0 94.0 1.0 SD C:MET578 5.0 97.5 1.0

A.Neuberger, Y.A.Trofimov, M.V.Yelshanskaya, J.Khau, K.D.Nadezhdin, L.S.Khosrof, N.A.Krylov, R.G.Efremov, A.I.Sobolevsky. Molecular Pathway and Structural Mechanism of Human Oncochannel TRPV6 Inhibition By the Phytocannabinoid Tetrahydrocannabivarin. Nat Commun V. 14 4630 2023.
ISSN: ESSN 2041-1723
PubMed: 37532722
DOI: 10.1038/S41467-023-40362-2