Chlorine in PDB 8sx4: Crystal Structure of EIF4E in Complex with Compound 7N

The structure of Crystal Structure of EIF4E in Complex with Compound 7N, PDB code: 8sx4 was solved by J.L.Meagher, J.A.Stuckey, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.81 / 1.99
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	49.125, 74.328, 51.877, 90, 97.13, 90
R / Rfree (%)	19.7 / 24.3

The binding sites of Chlorine atom in the Crystal Structure of EIF4E in Complex with Compound 7N (pdb code 8sx4). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of EIF4E in Complex with Compound 7N, PDB code: 8sx4:

Chlorine binding site 1 out of 1 in the Crystal Structure of EIF4E in Complex with Compound 7N


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of EIF4E in Complex with Compound 7N within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:25.0 occ:1.00 CL A:WXL301 0.0 25.0 1.0 C14 A:WXL301 1.7 25.2 1.0 C13 A:WXL301 2.7 25.6 1.0 C15 A:WXL301 2.7 25.5 1.0 OG A:SER92 3.1 17.1 1.0 CB A:SER92 3.8 15.3 1.0 C A:PHE47 3.8 23.1 1.0 N A:PHE48 3.9 25.2 1.0 CD2 A:LEU60 4.0 24.0 1.0 N A:SER92 4.0 17.5 1.0 O A:TRP46 4.0 17.6 1.0 CA A:PHE47 4.0 21.9 1.0 C16 A:WXL301 4.0 26.0 1.0 C12 A:WXL301 4.0 26.1 1.0 C A:TYR91 4.0 21.2 1.0 CB A:PHE48 4.1 29.2 1.0 C A:TRP46 4.1 17.8 1.0 N A:PHE47 4.1 18.9 1.0 CB A:TRP46 4.1 15.7 1.0 O A:PHE47 4.1 21.6 1.0 CA A:TYR91 4.3 26.3 1.0 O A:ASP90 4.3 29.6 1.0 CG A:PRO100 4.4 17.6 1.0 O A:TYR91 4.4 19.6 1.0 C17 A:WXL301 4.5 26.1 1.0 CA A:PHE48 4.5 29.2 1.0 CA A:SER92 4.5 15.7 1.0 N A:TYR91 4.6 27.6 1.0 CB A:PRO100 4.6 17.2 1.0 C A:ASP90 4.6 30.1 1.0 CA A:TRP46 4.8 16.1 1.0

E.L.Cardenas, R.L.O'rourke, A.Menon, J.Meagher, J.Stuckey, A.L.Garner. Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (EIF4E) For Inhibiting Aberrant Cap-Dependent Translation in Cancer. Biorxiv 2023.
ISSN: ISSN 2692-8205
PubMed: 37292917
DOI: 10.1101/2023.05.23.541912