Chlorine in PDB 8ta2: Cryo-Em Structure of the Human Clc-2 Chloride Channel Transmembrane Domain with Bound Inhibitor Ak-42

The binding sites of Chlorine atom in the Cryo-Em Structure of the Human Clc-2 Chloride Channel Transmembrane Domain with Bound Inhibitor Ak-42 (pdb code 8ta2). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Cryo-Em Structure of the Human Clc-2 Chloride Channel Transmembrane Domain with Bound Inhibitor Ak-42, PDB code: 8ta2:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in the Cryo-Em Structure of the Human Clc-2 Chloride Channel Transmembrane Domain with Bound Inhibitor Ak-42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of the Human Clc-2 Chloride Channel Transmembrane Domain with Bound Inhibitor Ak-42 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl601 b:40.0 occ:1.00 CL1 A:GH6601 0.0 40.0 1.0 C12 A:GH6601 1.8 34.0 1.0 HE21 A:GLN393 2.3 28.0 1.0 C14 A:GH6601 2.7 64.0 1.0 C11 A:GH6601 2.7 38.0 1.0 HD22 A:LEU196 2.8 48.0 1.0 H10 A:GH6601 2.9 74.0 1.0 H14 A:GH6601 2.9 64.0 1.0 N10 A:GH6601 3.0 74.0 1.0 NE2 A:GLN393 3.2 28.0 1.0 HB2 A:GLN393 3.4 60.0 1.0 HB3 A:LEU196 3.5 72.0 1.0 HE22 A:GLN393 3.5 28.0 1.0 HD13 A:LEU196 3.8 60.0 1.0 C09 A:GH6601 3.8 42.0 1.0 CD2 A:LEU196 3.8 48.0 1.0 C15 A:GH6601 4.0 78.0 1.0 C25 A:GH6601 4.0 56.0 1.0 HG2 A:MET460 4.1 96.0 1.0 O01 A:GH6601 4.1 38.0 1.0 HG3 A:GLN393 4.2 48.0 1.0 HD21 A:LEU196 4.2 48.0 1.0 CD A:GLN393 4.2 26.0 1.0 HG22 A:ILE112 4.3 36.0 1.0 O A:LEU202 4.3 46.0 1.0 N08 A:GH6601 4.3 48.0 1.0 CB A:GLN393 4.3 60.0 1.0 CB A:LEU196 4.4 72.0 1.0 CG A:GLN393 4.5 48.0 1.0 HD23 A:LEU196 4.5 48.0 1.0 CG A:LEU196 4.5 52.0 1.0 C16 A:GH6601 4.6 40.0 1.0 CD1 A:LEU196 4.6 60.0 1.0 HA A:LEU196 4.6 46.0 1.0 HE3 A:MET460 4.6 34.0 1.0 C04 A:GH6601 4.6 28.0 1.0 HB3 A:GLN393 4.7 60.0 1.0 O A:LEU196 4.8 48.0 1.0 HD12 A:LEU116 4.8 50.0 1.0 C02 A:GH6601 4.8 34.0 1.0 H51 A:GH6601 4.9 78.0 1.0 HD3 A:LYS204 4.9 36.0 1.0 H A:GLN393 4.9 52.0 1.0 HA2 A:GLY203 4.9 32.0 1.0 HZ2 A:LYS204 5.0 70.0 1.0

Chlorine binding site 2 out of 6 in the Cryo-Em Structure of the Human Clc-2 Chloride Channel Transmembrane Domain with Bound Inhibitor Ak-42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of the Human Clc-2 Chloride Channel Transmembrane Domain with Bound Inhibitor Ak-42 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl601 b:118.0 occ:1.00 CL2 A:GH6601 0.0 118.0 1.0 C25 A:GH6601 1.8 56.0 1.0 HE3 A:LYS394 2.7 62.0 1.0 C16 A:GH6601 2.7 40.0 1.0 C11 A:GH6601 2.7 38.0 1.0 O17 A:GH6601 3.0 44.0 1.0 HZ A:PHE306 3.0 46.0 1.0 HE2 A:LYS394 3.0 62.0 1.0 N10 A:GH6601 3.0 74.0 1.0 HB2 A:LYS394 3.2 46.0 1.0 CE A:LYS394 3.3 62.0 1.0 HE3 A:MET460 3.4 34.0 1.0 C09 A:GH6601 3.4 42.0 1.0 N08 A:GH6601 3.5 48.0 1.0 H10 A:GH6601 3.7 74.0 1.0 H20 A:GH6601 3.8 38.0 1.0 HE2 A:MET460 3.8 34.0 1.0 HE1 A:MET460 3.8 34.0 1.0 HZ3 A:LYS204 3.9 70.0 1.0 CE A:MET460 3.9 34.0 1.0 HE2 A:PHE306 3.9 52.0 1.0 HZ1 A:LYS394 3.9 66.0 1.0 CZ A:PHE306 4.0 46.0 1.0 C15 A:GH6601 4.0 78.0 1.0 C12 A:GH6601 4.0 34.0 1.0 HG3 A:LYS394 4.1 68.0 1.0 HZ2 A:LYS204 4.1 70.0 1.0 CB A:LYS394 4.2 46.0 1.0 NZ A:LYS394 4.2 66.0 1.0 C18 A:GH6601 4.3 42.0 1.0 C20 A:GH6601 4.3 38.0 1.0 C07 A:GH6601 4.4 36.0 1.0 CE2 A:PHE306 4.4 52.0 1.0 C04 A:GH6601 4.4 28.0 1.0 CG A:LYS394 4.4 68.0 1.0 NZ A:LYS204 4.4 70.0 1.0 CD A:LYS394 4.5 36.0 1.0 HA A:LYS394 4.5 44.0 1.0 HE2 A:LYS204 4.5 48.0 1.0 C14 A:GH6601 4.6 64.0 1.0 C19 A:GH6601 4.6 48.0 1.0 HZ2 A:LYS394 4.7 66.0 1.0 H18 A:GH6601 4.8 42.0 1.0 H07 A:GH6601 4.8 36.0 1.0 CA A:LYS394 4.9 44.0 1.0 H51 A:GH6601 4.9 78.0 1.0 HB3 A:LYS394 5.0 46.0 1.0 HZ3 A:LYS394 5.0 66.0 1.0

Chlorine binding site 3 out of 6 in the Cryo-Em Structure of the Human Clc-2 Chloride Channel Transmembrane Domain with Bound Inhibitor Ak-42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Cryo-Em Structure of the Human Clc-2 Chloride Channel Transmembrane Domain with Bound Inhibitor Ak-42 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl602 b:22.0 occ:1.00 H A:LYS204 2.2 32.0 1.0 H A:MET460 2.3 50.0 1.0 H A:GLU205 2.6 54.0 1.0 HB3 A:PHE459 2.8 50.0 1.0 H51 A:GH6601 2.9 78.0 1.0 H24 A:GH6601 3.0 44.0 1.0 HA3 A:GLY203 3.1 32.0 1.0 HB3 A:GLU205 3.1 50.0 1.0 HB2 A:MET460 3.1 62.0 1.0 N A:LYS204 3.2 32.0 1.0 H19 A:GH6601 3.2 42.0 1.0 N A:MET460 3.2 50.0 1.0 HB3 A:MET460 3.3 62.0 1.0 HA2 A:GLY203 3.3 32.0 1.0 HG2 A:LYS204 3.4 114.0 1.0 N A:GLU205 3.5 54.0 1.0 CA A:GLY203 3.6 32.0 1.0 CB A:MET460 3.6 62.0 1.0 HE1 A:PHE252 3.6 48.0 1.0 H A:PHE459 3.7 34.0 1.0 CB A:PHE459 3.8 50.0 1.0 C A:GLY203 3.8 24.0 1.0 HD1 A:PHE459 3.9 46.0 1.0 C15 A:GH6601 4.0 78.0 1.0 CA A:MET460 4.0 50.0 1.0 C24 A:GH6601 4.0 44.0 1.0 C A:PHE459 4.1 32.0 1.0 CB A:GLU205 4.1 50.0 1.0 CA A:LYS204 4.1 36.0 1.0 N A:PHE459 4.1 34.0 1.0 CA A:PHE459 4.2 38.0 1.0 C A:LYS204 4.2 36.0 1.0 C18 A:GH6601 4.2 42.0 1.0 H14 A:GH6601 4.3 64.0 1.0 CA A:GLU205 4.3 54.0 1.0 SG A:CYS251 4.4 38.0 1.0 HA A:MET460 4.4 50.0 1.0 CG A:LYS204 4.4 114.0 1.0 HB2 A:PHE459 4.4 50.0 1.0 OE1 A:GLU205 4.5 106.0 1.0 HD3 A:PRO461 4.6 54.0 1.0 HG A:CYS251 4.6 38.0 1.0 C19 A:GH6601 4.6 48.0 1.0 HB2 A:GLU205 4.6 50.0 1.0 CE1 A:PHE252 4.6 48.0 1.0 C14 A:GH6601 4.6 64.0 1.0 HA A:GLU205 4.6 54.0 1.0 CD1 A:PHE459 4.7 46.0 1.0 HG3 A:LYS204 4.7 114.0 1.0 CG A:PHE459 4.7 48.0 1.0 HD2 A:PRO461 4.8 54.0 1.0 H18 A:GH6601 4.8 42.0 1.0 CB A:LYS204 4.8 76.0 1.0 C16 A:GH6601 4.9 40.0 1.0 HE2 A:LYS204 5.0 48.0 1.0 N A:GLY203 5.0 58.0 1.0

Chlorine binding site 4 out of 6 in the Cryo-Em Structure of the Human Clc-2 Chloride Channel Transmembrane Domain with Bound Inhibitor Ak-42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Cryo-Em Structure of the Human Clc-2 Chloride Channel Transmembrane Domain with Bound Inhibitor Ak-42 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl601 b:44.0 occ:1.00 CL1 B:GH6601 0.0 44.0 1.0 C12 B:GH6601 1.7 46.0 1.0 C14 B:GH6601 2.7 50.0 1.0 C11 B:GH6601 2.7 46.0 1.0 H10 B:GH6601 2.8 42.0 1.0 H14 B:GH6601 2.8 50.0 1.0 N10 B:GH6601 3.0 42.0 1.0 HB2 B:GLN393 3.3 56.0 1.0 OE1 B:GLN393 3.3 34.0 1.0 HD22 B:LEU196 3.4 20.0 1.0 HB3 B:LEU196 3.6 80.0 1.0 O B:LEU202 3.9 46.0 1.0 HD13 B:LEU196 3.9 80.0 1.0 C09 B:GH6601 4.0 38.0 1.0 HG2 B:MET460 4.0 76.0 1.0 C15 B:GH6601 4.0 52.0 1.0 C25 B:GH6601 4.1 42.0 1.0 O03 B:GH6601 4.1 70.0 1.0 CD B:GLN393 4.1 28.0 1.0 HG3 B:GLN393 4.1 60.0 1.0 CB B:GLN393 4.2 56.0 1.0 CG B:GLN393 4.4 60.0 1.0 CD2 B:LEU196 4.5 20.0 1.0 HD12 B:LEU116 4.5 44.0 1.0 N08 B:GH6601 4.5 48.0 1.0 C16 B:GH6601 4.6 50.0 1.0 HB3 B:GLN393 4.6 56.0 1.0 HG22 B:ILE112 4.6 58.0 1.0 CB B:LEU196 4.6 80.0 1.0 HE2 B:MET460 4.7 24.0 1.0 HE3 B:LYS204 4.7 64.0 1.0 C04 B:GH6601 4.8 34.0 1.0 HA B:LEU196 4.8 50.0 1.0 C02 B:GH6601 4.8 40.0 1.0 H B:GLN393 4.8 58.0 1.0 H51 B:GH6601 4.8 52.0 1.0 CD1 B:LEU196 4.9 80.0 1.0 H B:LEU202 4.9 58.0 1.0 CG B:LEU196 4.9 54.0 1.0

Chlorine binding site 5 out of 6 in the Cryo-Em Structure of the Human Clc-2 Chloride Channel Transmembrane Domain with Bound Inhibitor Ak-42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Cryo-Em Structure of the Human Clc-2 Chloride Channel Transmembrane Domain with Bound Inhibitor Ak-42 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl601 b:64.0 occ:1.00 CL2 B:GH6601 0.0 64.0 1.0 C25 B:GH6601 1.8 42.0 1.0 H19 B:GH6601 2.5 78.0 1.0 HE3 B:LYS394 2.6 108.0 1.0 C11 B:GH6601 2.7 46.0 1.0 C16 B:GH6601 2.8 50.0 1.0 N10 B:GH6601 3.1 42.0 1.0 HE2 B:LYS394 3.1 108.0 1.0 O17 B:GH6601 3.1 66.0 1.0 N08 B:GH6601 3.2 48.0 1.0 HG3 B:LYS394 3.2 56.0 1.0 C18 B:GH6601 3.2 78.0 1.0 C09 B:GH6601 3.3 38.0 1.0 CE B:LYS394 3.3 108.0 1.0 HZ3 B:LYS204 3.4 48.0 1.0 HG2 B:LYS394 3.5 56.0 1.0 HZ2 B:LYS204 3.6 48.0 1.0 HE3 B:MET460 3.6 24.0 1.0 CG B:LYS394 3.8 56.0 1.0 H10 B:GH6601 3.9 42.0 1.0 NZ B:LYS204 4.0 48.0 1.0 C07 B:GH6601 4.0 38.0 1.0 H18 B:GH6601 4.0 78.0 1.0 C15 B:GH6601 4.0 52.0 1.0 C12 B:GH6601 4.0 46.0 1.0 CD B:LYS394 4.2 76.0 1.0 HE3 B:LYS204 4.2 64.0 1.0 C19 B:GH6601 4.2 60.0 1.0 HE2 B:MET460 4.2 24.0 1.0 CE B:MET460 4.3 24.0 1.0 HZ B:PHE306 4.3 36.0 1.0 C04 B:GH6601 4.3 34.0 1.0 H07 B:GH6601 4.3 38.0 1.0 HE1 B:MET460 4.4 24.0 1.0 HZ1 B:LYS394 4.5 84.0 1.0 NZ B:LYS394 4.5 84.0 1.0 H20 B:GH6601 4.5 40.0 1.0 C14 B:GH6601 4.6 50.0 1.0 HG22 B:THR301 4.6 104.0 1.0 CE B:LYS204 4.7 64.0 1.0 C20 B:GH6601 4.7 40.0 1.0 HZ1 B:LYS204 4.7 48.0 1.0 HD2 B:LYS394 4.8 76.0 1.0 C06 B:GH6601 4.9 48.0 1.0 H51 B:GH6601 4.9 52.0 1.0 HZ3 B:LYS394 4.9 84.0 1.0 HD3 B:LYS394 5.0 76.0 1.0 C05 B:GH6601 5.0 36.0 1.0

Chlorine binding site 6 out of 6 in the Cryo-Em Structure of the Human Clc-2 Chloride Channel Transmembrane Domain with Bound Inhibitor Ak-42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Cryo-Em Structure of the Human Clc-2 Chloride Channel Transmembrane Domain with Bound Inhibitor Ak-42 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl602 b:32.0 occ:1.00 H B:LYS204 2.2 60.0 1.0 H B:MET460 2.3 34.0 1.0 H B:GLU205 2.7 52.0 1.0 HB3 B:PHE459 2.8 50.0 1.0 H51 B:GH6601 2.9 52.0 1.0 HB3 B:GLU205 3.0 42.0 1.0 H24 B:GH6601 3.1 50.0 1.0 HA3 B:GLY203 3.1 62.0 1.0 N B:LYS204 3.2 60.0 1.0 HB2 B:MET460 3.2 52.0 1.0 N B:MET460 3.2 34.0 1.0 HA2 B:GLY203 3.3 62.0 1.0 HE1 B:PHE252 3.3 44.0 1.0 H B:PHE459 3.4 52.0 1.0 HG2 B:LYS204 3.5 58.0 1.0 HB3 B:MET460 3.5 52.0 1.0 N B:GLU205 3.6 52.0 1.0 CA B:GLY203 3.6 62.0 1.0 HD1 B:PHE459 3.7 68.0 1.0 CB B:MET460 3.8 52.0 1.0 CB B:PHE459 3.8 50.0 1.0 C B:GLY203 3.9 34.0 1.0 C15 B:GH6601 4.0 52.0 1.0 N B:PHE459 4.0 52.0 1.0 CB B:GLU205 4.0 42.0 1.0 H23 B:GH6601 4.1 40.0 1.0 C B:PHE459 4.1 42.0 1.0 C24 B:GH6601 4.1 50.0 1.0 CA B:PHE459 4.1 40.0 1.0 CA B:MET460 4.1 48.0 1.0 CA B:LYS204 4.2 46.0 1.0 C B:LYS204 4.3 40.0 1.0 OE1 B:GLU205 4.3 58.0 1.0 HG B:CYS251 4.4 40.0 1.0 CG B:LYS204 4.4 58.0 1.0 CA B:GLU205 4.4 42.0 1.0 CE1 B:PHE252 4.4 44.0 1.0 HG3 B:LYS204 4.4 58.0 1.0 HB2 B:PHE459 4.5 50.0 1.0 CD1 B:PHE459 4.5 68.0 1.0 SG B:CYS251 4.5 40.0 1.0 H14 B:GH6601 4.5 50.0 1.0 C23 B:GH6601 4.5 40.0 1.0 HA B:MET460 4.6 48.0 1.0 HD2 B:PRO461 4.6 72.0 1.0 HD3 B:PRO461 4.7 72.0 1.0 CG B:PHE459 4.7 50.0 1.0 O17 B:GH6601 4.7 66.0 1.0 HB2 B:GLU205 4.7 42.0 1.0 C14 B:GH6601 4.7 50.0 1.0 HA B:GLU205 4.7 42.0 1.0 CD B:GLU205 4.8 42.0 1.0 CB B:LYS204 4.8 56.0 1.0 CG B:GLU205 4.8 42.0 1.0 C16 B:GH6601 4.9 50.0 1.0 H B:ALA458 4.9 58.0 1.0 HA3 B:GLY457 5.0 52.0 1.0 HG3 B:GLU205 5.0 42.0 1.0 N B:GLY203 5.0 44.0 1.0

M.Xu, T.Neelands, A.S.Powers, Y.Liu, S.Miller, G.Pintilie, J.Du Bois, R.O.Dror, W.Chiu, M.Maduke. Cryo-Em Structures of the Human Clc-2 Voltage Gated Chloride Channel Reveal A Closed Conformational State and Pore Block By An N-Terminal Hairpin Peptide To Be Published.