Chlorine in PDB 8tc7: Human Asparaginyl-Trna Synthetase, Apo Form

Enzymatic activity of Human Asparaginyl-Trna Synthetase, Apo Form

All present enzymatic activity of Human Asparaginyl-Trna Synthetase, Apo Form:
6.1.1.22;

Protein crystallography data

The structure of Human Asparaginyl-Trna Synthetase, Apo Form, PDB code: 8tc7 was solved by C.Dogovski, R.D.Metcalfe, S.C.Xie, C.J.Morton, L.Tilley, M.D.W.Griffin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.58 / 1.90
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 113.49, 127.195, 163.16, 90, 90, 90
R / Rfree (%) 18.1 / 21.7

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human Asparaginyl-Trna Synthetase, Apo Form (pdb code 8tc7). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human Asparaginyl-Trna Synthetase, Apo Form, PDB code: 8tc7:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 8tc7

Go back to Chlorine Binding Sites List in 8tc7
Chlorine binding site 1 out of 2 in the Human Asparaginyl-Trna Synthetase, Apo Form


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Asparaginyl-Trna Synthetase, Apo Form within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl610

b:70.5
occ:1.00
O B:HOH968 2.3 54.5 1.0
O B:HOH1013 2.7 64.3 1.0
NH2 B:ARG127 3.2 46.4 1.0
CD2 B:PHE204 4.0 48.4 1.0
NH1 B:ARG127 4.1 41.9 1.0
CZ B:ARG127 4.1 48.4 1.0
CG B:PHE204 4.2 48.3 1.0
CB B:PHE204 4.4 43.4 1.0
CD2 B:TYR182 4.5 42.3 1.0
CE2 B:PHE204 4.6 51.8 1.0
CE2 B:TYR182 4.7 37.8 1.0
CB B:LEU109 4.7 69.7 1.0
CG B:TYR182 4.9 39.0 1.0
CD1 B:PHE204 4.9 51.0 1.0

Chlorine binding site 2 out of 2 in 8tc7

Go back to Chlorine Binding Sites List in 8tc7
Chlorine binding site 2 out of 2 in the Human Asparaginyl-Trna Synthetase, Apo Form


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Asparaginyl-Trna Synthetase, Apo Form within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl604

b:83.5
occ:1.00
NH2 C:ARG127 3.5 60.9 1.0
NH1 C:ARG127 4.0 73.6 1.0
CD2 C:PHE204 4.2 45.4 1.0
CZ C:ARG127 4.3 59.4 1.0
CD2 C:TYR182 4.4 42.6 1.0
CE2 C:TYR182 4.4 43.4 1.0
CE2 C:PHE204 4.6 48.2 1.0
CG C:PHE204 4.6 48.1 1.0
CB C:PHE204 4.9 44.1 1.0

Reference:

S.C.Xie, L.Tilley. Human Asparaginyl-Trna Synthetase, Apo Form Nat Commun 2024.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-024-45224-Z
Page generated: Tue Jul 30 12:47:00 2024

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