Chlorine in PDB 8uh6: Degrader-Induced Complex Between PTPN2 and Crbn-DDB1

All present enzymatic activity of Degrader-Induced Complex Between PTPN2 and Crbn-DDB1:
3.1.3.48;

The structure of Degrader-Induced Complex Between PTPN2 and Crbn-DDB1 also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Chlorine atom in the Degrader-Induced Complex Between PTPN2 and Crbn-DDB1 (pdb code 8uh6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Degrader-Induced Complex Between PTPN2 and Crbn-DDB1, PDB code: 8uh6:

Chlorine binding site 1 out of 1 in the Degrader-Induced Complex Between PTPN2 and Crbn-DDB1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Degrader-Induced Complex Between PTPN2 and Crbn-DDB1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl501 b:32.3 occ:1.00 CL01 B:WO8501 0.0 32.3 1.0 C02 B:WO8501 1.8 36.4 1.0 C62 B:WO8501 2.8 38.4 1.0 C03 B:WO8501 2.8 33.8 1.0 O63 B:WO8501 3.2 34.4 1.0 C05 B:WO8501 3.3 28.2 1.0 C04 B:WO8501 3.4 36.1 1.0 C64 B:WO8501 3.6 34.8 1.0 C65 B:WO8501 4.0 31.8 1.0 C58 B:WO8501 4.1 38.1 1.0 N C:GLY221 4.1 77.9 1.0 CB C:ALA218 4.2 73.4 1.0 O66 B:WO8501 4.2 27.2 1.0 S57 B:WO8501 4.2 16.6 1.0 CA C:GLY221 4.4 84.0 1.0 CB C:ILE220 4.4 71.2 1.0 C06 B:WO8501 4.4 27.5 1.0 C56 B:WO8501 4.6 32.9 1.0 OE1 C:GLN260 4.6 37.1 1.0 CG2 C:ILE220 4.6 64.9 1.0 O67 B:WO8501 4.7 37.1 1.0 CG C:GLN260 4.7 38.8 1.0 CD C:GLN260 4.9 39.7 1.0

Q.Hao, M.K.Rathinaswamy, K.L.Klinge, M.Bratkowski, A.Mafi, C.K.Baumgartner, K.M.Hamel, G.K.Veits, R.Jain, C.Catalano, M.Fitzgerald, A.W.Hird, E.Park, H.U.Vora, J.A.Henderson, K.Longenecker, C.W.Hutchins, W.Qiu, G.Scapin, Q.Sun, V.S.Stoll, C.Sun, P.Li, D.Eaton, D.Stokoe, S.L.Fisher, C.G.Nasveschuk, M.Paddock, M.E.Kort. Mechanistic Insights Into A Heterobifunctional Degrader-Induced PTPN2/N1 Complex. Commun Chem V. 7 183 2024.
ISSN: ESSN 2399-3669
PubMed: 39152201
DOI: 10.1038/S42004-024-01263-7