Chlorine in PDB 8v8c: ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1
Other elements in 8v8c:
The structure of ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1
(pdb code 8v8c). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 10 binding sites of Chlorine where determined in the
ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1, PDB code: 8v8c:
Jump to Chlorine binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Chlorine binding site 1 out
of 10 in 8v8c
Go back to
Chlorine Binding Sites List in 8v8c
Chlorine binding site 1 out
of 10 in the ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl603
b:79.7
occ:1.00
|
CL
|
A:EPJ603
|
0.0
|
79.7
|
1.0
|
|
C10
|
A:EPJ603
|
1.7
|
79.7
|
1.0
|
|
N2
|
A:EPJ603
|
2.6
|
79.7
|
1.0
|
|
C9
|
A:EPJ603
|
2.7
|
79.7
|
1.0
|
|
HB3
|
B:LEU108
|
2.8
|
79.0
|
1.0
|
|
HB2
|
B:LEU108
|
2.8
|
79.0
|
1.0
|
|
H9
|
A:EPJ603
|
2.9
|
79.7
|
1.0
|
|
H
|
B:LEU108
|
3.0
|
79.0
|
1.0
|
|
O
|
B:GLN116
|
3.1
|
77.3
|
1.0
|
|
CB
|
B:LEU108
|
3.3
|
79.0
|
1.0
|
|
N
|
B:LEU108
|
3.6
|
79.0
|
1.0
|
|
O
|
B:ASN106
|
3.6
|
79.3
|
1.0
|
|
HB3
|
A:SER149
|
3.7
|
80.2
|
1.0
|
|
HB3
|
B:GLN116
|
3.7
|
77.3
|
1.0
|
|
HA
|
B:TYR117
|
3.7
|
76.0
|
1.0
|
|
HB2
|
A:SER149
|
3.8
|
80.2
|
1.0
|
|
HD13
|
B:LEU118
|
3.8
|
76.0
|
1.0
|
|
C11
|
A:EPJ603
|
3.8
|
79.7
|
1.0
|
|
H
|
B:LEU118
|
3.8
|
76.0
|
1.0
|
|
C
|
B:GLN116
|
3.9
|
77.3
|
1.0
|
|
C8
|
A:EPJ603
|
4.0
|
79.7
|
1.0
|
|
HA
|
B:VAL107
|
4.0
|
77.3
|
1.0
|
|
HD22
|
B:LEU108
|
4.0
|
79.0
|
1.0
|
|
CA
|
B:LEU108
|
4.1
|
79.0
|
1.0
|
|
HD23
|
B:LEU108
|
4.2
|
79.0
|
1.0
|
|
HB2
|
B:LEU118
|
4.2
|
76.0
|
1.0
|
|
CB
|
A:SER149
|
4.3
|
80.2
|
1.0
|
|
HD12
|
B:LEU118
|
4.3
|
76.0
|
1.0
|
|
CD2
|
B:LEU108
|
4.4
|
79.0
|
1.0
|
|
CA
|
B:TYR117
|
4.4
|
76.0
|
1.0
|
|
C7
|
A:EPJ603
|
4.4
|
79.7
|
1.0
|
|
C
|
B:VAL107
|
4.5
|
77.3
|
1.0
|
|
N
|
B:LEU118
|
4.5
|
76.0
|
1.0
|
|
CG
|
B:LEU108
|
4.5
|
79.0
|
1.0
|
|
C
|
B:ASN106
|
4.5
|
79.3
|
1.0
|
|
N
|
B:TYR117
|
4.5
|
76.0
|
1.0
|
|
CD1
|
B:LEU118
|
4.6
|
76.0
|
1.0
|
|
CA
|
B:VAL107
|
4.6
|
77.3
|
1.0
|
|
HA
|
A:SER149
|
4.6
|
80.2
|
1.0
|
|
H11
|
A:EPJ603
|
4.7
|
79.7
|
1.0
|
|
HA
|
B:LEU108
|
4.7
|
79.0
|
1.0
|
|
CB
|
B:GLN116
|
4.7
|
77.3
|
1.0
|
|
H8
|
A:EPJ603
|
4.8
|
79.7
|
1.0
|
|
HG2
|
B:GLN116
|
4.9
|
77.3
|
1.0
|
|
HB2
|
B:ASN106
|
4.9
|
79.3
|
1.0
|
|
N
|
B:VAL107
|
4.9
|
77.3
|
1.0
|
|
CA
|
B:GLN116
|
4.9
|
77.3
|
1.0
|
|
HD1
|
A:TRP148
|
4.9
|
76.7
|
1.0
|
|
C
|
B:TYR117
|
5.0
|
76.0
|
1.0
|
|
Chlorine binding site 2 out
of 10 in 8v8c
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Chlorine Binding Sites List in 8v8c
Chlorine binding site 2 out
of 10 in the ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl604
b:72.1
occ:1.00
|
CL1
|
A:I34604
|
0.0
|
72.1
|
1.0
|
|
C20
|
A:I34604
|
1.7
|
72.1
|
1.0
|
|
C19
|
A:I34604
|
2.7
|
72.1
|
1.0
|
|
C03
|
A:I34604
|
2.7
|
72.1
|
1.0
|
|
H12
|
A:I34604
|
2.8
|
72.1
|
1.0
|
|
O02
|
A:I34604
|
2.9
|
72.1
|
1.0
|
|
HB3
|
B:PRO217
|
3.3
|
66.8
|
1.0
|
|
HD11
|
B:ILE221
|
3.3
|
69.7
|
1.0
|
|
SD
|
A:MET278
|
3.4
|
71.9
|
1.0
|
|
HG22
|
A:THR250
|
3.6
|
73.0
|
1.0
|
|
HZ
|
B:PHE252
|
3.7
|
70.2
|
1.0
|
|
HB2
|
B:PRO217
|
3.8
|
66.8
|
1.0
|
|
C08
|
A:I34604
|
4.0
|
72.1
|
1.0
|
|
C04
|
A:I34604
|
4.0
|
72.1
|
1.0
|
|
CB
|
B:PRO217
|
4.1
|
66.8
|
1.0
|
|
HE1
|
A:MET278
|
4.1
|
71.9
|
1.0
|
|
HG21
|
A:THR250
|
4.3
|
73.0
|
1.0
|
|
HG13
|
B:ILE221
|
4.3
|
69.7
|
1.0
|
|
C01
|
A:I34604
|
4.3
|
72.1
|
1.0
|
|
CD1
|
B:ILE221
|
4.3
|
69.7
|
1.0
|
|
CE
|
A:MET278
|
4.3
|
71.9
|
1.0
|
|
CG2
|
A:THR250
|
4.4
|
73.0
|
1.0
|
|
HB3
|
A:MET278
|
4.4
|
71.9
|
1.0
|
|
HB
|
A:THR250
|
4.4
|
73.0
|
1.0
|
|
C05
|
A:I34604
|
4.5
|
72.1
|
1.0
|
|
HA
|
B:PRO217
|
4.6
|
66.8
|
1.0
|
|
HD12
|
B:ILE221
|
4.6
|
69.7
|
1.0
|
|
HE3
|
A:MET278
|
4.7
|
71.9
|
1.0
|
|
HA
|
A:THR250
|
4.7
|
73.0
|
1.0
|
|
H1
|
A:I34604
|
4.7
|
72.1
|
1.0
|
|
CG1
|
B:ILE221
|
4.7
|
69.7
|
1.0
|
|
HG12
|
B:ILE221
|
4.7
|
69.7
|
1.0
|
|
CZ
|
B:PHE252
|
4.7
|
70.2
|
1.0
|
|
H3
|
A:I34604
|
4.8
|
72.1
|
1.0
|
|
H2
|
A:I34604
|
4.8
|
72.1
|
1.0
|
|
H4
|
A:I34604
|
4.8
|
72.1
|
1.0
|
|
CA
|
B:PRO217
|
4.9
|
66.8
|
1.0
|
|
CG
|
A:MET278
|
4.9
|
71.9
|
1.0
|
|
HB2
|
A:MET278
|
4.9
|
71.9
|
1.0
|
|
CB
|
A:THR250
|
4.9
|
73.0
|
1.0
|
|
CB
|
A:MET278
|
5.0
|
71.9
|
1.0
|
|
O11
|
A:I34604
|
5.0
|
72.1
|
1.0
|
|
Chlorine binding site 3 out
of 10 in 8v8c
Go back to
Chlorine Binding Sites List in 8v8c
Chlorine binding site 3 out
of 10 in the ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl604
b:81.0
occ:1.00
|
CL
|
B:EPJ604
|
0.0
|
81.0
|
1.0
|
|
C10
|
B:EPJ604
|
1.7
|
81.0
|
1.0
|
|
N2
|
B:EPJ604
|
2.6
|
81.0
|
1.0
|
|
C9
|
B:EPJ604
|
2.7
|
81.0
|
1.0
|
|
HB2
|
C:LEU108
|
2.7
|
79.9
|
1.0
|
|
H9
|
B:EPJ604
|
2.9
|
81.0
|
1.0
|
|
H
|
C:LEU108
|
2.9
|
79.9
|
1.0
|
|
O
|
C:GLN116
|
3.1
|
79.8
|
1.0
|
|
O
|
C:ASN106
|
3.2
|
78.8
|
1.0
|
|
HB3
|
C:LEU108
|
3.2
|
79.9
|
1.0
|
|
HA
|
C:VAL107
|
3.3
|
79.0
|
1.0
|
|
N
|
C:LEU108
|
3.3
|
79.9
|
1.0
|
|
HG
|
B:SER149
|
3.4
|
80.0
|
1.0
|
|
CB
|
C:LEU108
|
3.4
|
79.9
|
1.0
|
|
HB2
|
B:SER149
|
3.5
|
80.0
|
1.0
|
|
HA
|
C:TYR117
|
3.6
|
78.0
|
1.0
|
|
OG
|
B:SER149
|
3.6
|
80.0
|
1.0
|
|
H
|
C:LEU118
|
3.7
|
78.7
|
1.0
|
|
C11
|
B:EPJ604
|
3.8
|
81.0
|
1.0
|
|
C8
|
B:EPJ604
|
4.0
|
81.0
|
1.0
|
|
C
|
C:VAL107
|
4.0
|
79.0
|
1.0
|
|
CA
|
C:LEU108
|
4.0
|
79.9
|
1.0
|
|
CA
|
C:VAL107
|
4.0
|
79.0
|
1.0
|
|
C
|
C:ASN106
|
4.0
|
78.8
|
1.0
|
|
C
|
C:GLN116
|
4.1
|
79.8
|
1.0
|
|
CB
|
B:SER149
|
4.1
|
80.0
|
1.0
|
|
HD13
|
C:LEU118
|
4.3
|
78.7
|
1.0
|
|
HG2
|
C:GLN116
|
4.3
|
79.8
|
1.0
|
|
HD22
|
C:LEU108
|
4.3
|
79.9
|
1.0
|
|
HB2
|
C:LEU118
|
4.4
|
78.7
|
1.0
|
|
N
|
C:VAL107
|
4.4
|
79.0
|
1.0
|
|
CA
|
C:TYR117
|
4.4
|
78.0
|
1.0
|
|
HB3
|
C:GLN116
|
4.4
|
79.8
|
1.0
|
|
C7
|
B:EPJ604
|
4.5
|
81.0
|
1.0
|
|
N
|
C:LEU118
|
4.5
|
78.7
|
1.0
|
|
HA
|
C:LEU108
|
4.5
|
79.9
|
1.0
|
|
HA
|
B:SER149
|
4.6
|
80.0
|
1.0
|
|
N
|
C:TYR117
|
4.6
|
78.0
|
1.0
|
|
H11
|
B:EPJ604
|
4.7
|
81.0
|
1.0
|
|
CG
|
C:LEU108
|
4.7
|
79.9
|
1.0
|
|
HD1
|
B:TRP148
|
4.7
|
76.8
|
1.0
|
|
HB2
|
C:ASN106
|
4.8
|
78.8
|
1.0
|
|
HD1
|
C:TYR117
|
4.8
|
78.0
|
1.0
|
|
HD23
|
C:LEU108
|
4.8
|
79.9
|
1.0
|
|
H8
|
B:EPJ604
|
4.8
|
81.0
|
1.0
|
|
CD2
|
C:LEU108
|
4.9
|
79.9
|
1.0
|
|
HD13
|
C:LEU108
|
4.9
|
79.9
|
1.0
|
|
HB3
|
B:SER149
|
4.9
|
80.0
|
1.0
|
|
HD12
|
C:LEU118
|
4.9
|
78.7
|
1.0
|
|
HG2
|
C:ARG78
|
4.9
|
79.9
|
1.0
|
|
CA
|
B:SER149
|
4.9
|
80.0
|
1.0
|
|
HB3
|
C:ASN106
|
4.9
|
78.8
|
1.0
|
|
O
|
C:VAL107
|
5.0
|
79.0
|
1.0
|
|
C
|
C:TYR117
|
5.0
|
78.0
|
1.0
|
|
Chlorine binding site 4 out
of 10 in 8v8c
Go back to
Chlorine Binding Sites List in 8v8c
Chlorine binding site 4 out
of 10 in the ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl605
b:71.8
occ:1.00
|
CL1
|
B:I34605
|
0.0
|
71.8
|
1.0
|
|
C20
|
B:I34605
|
1.7
|
71.8
|
1.0
|
|
HE1
|
B:MET278
|
2.1
|
70.0
|
1.0
|
|
C19
|
B:I34605
|
2.7
|
71.8
|
1.0
|
|
C03
|
B:I34605
|
2.7
|
71.8
|
1.0
|
|
H12
|
B:I34605
|
2.8
|
71.8
|
1.0
|
|
O02
|
B:I34605
|
2.9
|
71.8
|
1.0
|
|
HE2
|
B:MET278
|
3.0
|
70.0
|
1.0
|
|
CE
|
B:MET278
|
3.0
|
70.0
|
1.0
|
|
HG22
|
B:THR250
|
3.0
|
72.9
|
1.0
|
|
HB3
|
C:PRO217
|
3.1
|
67.1
|
1.0
|
|
HZ
|
C:PHE252
|
3.1
|
72.7
|
1.0
|
|
HD11
|
C:ILE221
|
3.1
|
70.1
|
1.0
|
|
HE3
|
B:MET278
|
3.8
|
70.0
|
1.0
|
|
SD
|
B:MET278
|
3.9
|
70.0
|
1.0
|
|
C08
|
B:I34605
|
4.0
|
71.8
|
1.0
|
|
C04
|
B:I34605
|
4.0
|
71.8
|
1.0
|
|
CG2
|
B:THR250
|
4.0
|
72.9
|
1.0
|
|
CZ
|
C:PHE252
|
4.1
|
72.7
|
1.0
|
|
CD1
|
C:ILE221
|
4.1
|
70.1
|
1.0
|
|
CB
|
C:PRO217
|
4.1
|
67.1
|
1.0
|
|
HB
|
B:THR250
|
4.1
|
72.9
|
1.0
|
|
HG21
|
B:THR250
|
4.2
|
72.9
|
1.0
|
|
HD12
|
C:ILE221
|
4.2
|
70.1
|
1.0
|
|
C01
|
B:I34605
|
4.3
|
71.8
|
1.0
|
|
HE2
|
C:PHE252
|
4.3
|
72.7
|
1.0
|
|
HB2
|
C:PRO217
|
4.4
|
67.1
|
1.0
|
|
HA
|
B:THR250
|
4.4
|
72.9
|
1.0
|
|
C05
|
B:I34605
|
4.5
|
71.8
|
1.0
|
|
HG3
|
B:MET253
|
4.5
|
71.8
|
1.0
|
|
CB
|
B:THR250
|
4.6
|
72.9
|
1.0
|
|
HD13
|
C:ILE221
|
4.6
|
70.1
|
1.0
|
|
CE2
|
C:PHE252
|
4.7
|
72.7
|
1.0
|
|
H1
|
B:I34605
|
4.7
|
71.8
|
1.0
|
|
HG2
|
C:PRO217
|
4.8
|
67.1
|
1.0
|
|
H3
|
B:I34605
|
4.8
|
71.8
|
1.0
|
|
HG23
|
B:THR250
|
4.8
|
72.9
|
1.0
|
|
H2
|
B:I34605
|
4.8
|
71.8
|
1.0
|
|
CG
|
C:PRO217
|
4.8
|
67.1
|
1.0
|
|
HG3
|
C:PRO217
|
4.8
|
67.1
|
1.0
|
|
H4
|
B:I34605
|
4.8
|
71.8
|
1.0
|
|
O11
|
B:I34605
|
5.0
|
71.8
|
1.0
|
|
HB3
|
B:MET278
|
5.0
|
70.0
|
1.0
|
|
Chlorine binding site 5 out
of 10 in 8v8c
Go back to
Chlorine Binding Sites List in 8v8c
Chlorine binding site 5 out
of 10 in the ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Cl604
b:80.2
occ:1.00
|
CL
|
C:EPJ604
|
0.0
|
80.2
|
1.0
|
|
C10
|
C:EPJ604
|
1.7
|
80.2
|
1.0
|
|
N2
|
C:EPJ604
|
2.6
|
80.2
|
1.0
|
|
C9
|
C:EPJ604
|
2.7
|
80.2
|
1.0
|
|
HB2
|
D:LEU108
|
2.8
|
77.4
|
1.0
|
|
H9
|
C:EPJ604
|
2.9
|
80.2
|
1.0
|
|
HB3
|
D:LEU108
|
3.1
|
77.4
|
1.0
|
|
HB3
|
C:SER149
|
3.2
|
78.2
|
1.0
|
|
H
|
D:LEU108
|
3.4
|
77.4
|
1.0
|
|
CB
|
D:LEU108
|
3.4
|
77.4
|
1.0
|
|
O
|
D:GLN116
|
3.6
|
78.4
|
1.0
|
|
HD13
|
D:LEU118
|
3.6
|
76.6
|
1.0
|
|
HB2
|
C:SER149
|
3.7
|
78.2
|
1.0
|
|
HG2
|
D:GLN116
|
3.8
|
78.4
|
1.0
|
|
O
|
D:ASN106
|
3.8
|
77.5
|
1.0
|
|
HD13
|
D:LEU108
|
3.8
|
77.4
|
1.0
|
|
C11
|
C:EPJ604
|
3.8
|
80.2
|
1.0
|
|
N
|
D:LEU108
|
3.9
|
77.4
|
1.0
|
|
CB
|
C:SER149
|
3.9
|
78.2
|
1.0
|
|
C8
|
C:EPJ604
|
4.0
|
80.2
|
1.0
|
|
HA
|
D:TYR117
|
4.0
|
75.9
|
1.0
|
|
H
|
D:LEU118
|
4.0
|
76.6
|
1.0
|
|
HD12
|
D:LEU118
|
4.1
|
76.6
|
1.0
|
|
HA
|
C:SER149
|
4.1
|
78.2
|
1.0
|
|
HB2
|
D:LEU118
|
4.1
|
76.6
|
1.0
|
|
HA
|
D:VAL107
|
4.2
|
76.6
|
1.0
|
|
CA
|
D:LEU108
|
4.3
|
77.4
|
1.0
|
|
HD12
|
D:LEU108
|
4.3
|
77.4
|
1.0
|
|
CD1
|
D:LEU118
|
4.4
|
76.6
|
1.0
|
|
CD1
|
D:LEU108
|
4.4
|
77.4
|
1.0
|
|
C
|
D:GLN116
|
4.5
|
78.4
|
1.0
|
|
C7
|
C:EPJ604
|
4.5
|
80.2
|
1.0
|
|
CG
|
D:LEU108
|
4.5
|
77.4
|
1.0
|
|
CA
|
C:SER149
|
4.6
|
78.2
|
1.0
|
|
HD1
|
C:TRP148
|
4.6
|
76.2
|
1.0
|
|
C
|
D:ASN106
|
4.6
|
77.5
|
1.0
|
|
N
|
D:LEU118
|
4.6
|
76.6
|
1.0
|
|
C
|
D:VAL107
|
4.7
|
76.6
|
1.0
|
|
H11
|
C:EPJ604
|
4.7
|
80.2
|
1.0
|
|
HE21
|
D:GLN116
|
4.7
|
78.4
|
1.0
|
|
CA
|
D:TYR117
|
4.8
|
75.9
|
1.0
|
|
HA
|
D:LEU108
|
4.8
|
77.4
|
1.0
|
|
CG
|
D:GLN116
|
4.8
|
78.4
|
1.0
|
|
H8
|
C:EPJ604
|
4.8
|
80.2
|
1.0
|
|
CA
|
D:VAL107
|
4.8
|
76.6
|
1.0
|
|
HH
|
C:TYR194
|
4.9
|
82.9
|
1.0
|
|
HD22
|
D:LEU108
|
4.9
|
77.4
|
1.0
|
|
HB2
|
D:ASN106
|
4.9
|
77.5
|
1.0
|
|
N
|
D:TYR117
|
4.9
|
75.9
|
1.0
|
|
O
|
C:TRP148
|
5.0
|
76.2
|
1.0
|
|
HG2
|
D:ARG78
|
5.0
|
77.9
|
1.0
|
|
Chlorine binding site 6 out
of 10 in 8v8c
Go back to
Chlorine Binding Sites List in 8v8c
Chlorine binding site 6 out
of 10 in the ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Cl605
b:73.2
occ:1.00
|
CL1
|
C:I34605
|
0.0
|
73.2
|
1.0
|
|
C20
|
C:I34605
|
1.7
|
73.2
|
1.0
|
|
C19
|
C:I34605
|
2.7
|
73.2
|
1.0
|
|
C03
|
C:I34605
|
2.7
|
73.2
|
1.0
|
|
H12
|
C:I34605
|
2.8
|
73.2
|
1.0
|
|
HG22
|
C:THR250
|
2.8
|
73.6
|
1.0
|
|
O02
|
C:I34605
|
2.9
|
73.2
|
1.0
|
|
HZ
|
D:PHE252
|
3.0
|
73.9
|
1.0
|
|
HD11
|
D:ILE221
|
3.0
|
71.9
|
1.0
|
|
HB3
|
D:PRO217
|
3.0
|
70.0
|
1.0
|
|
HE2
|
D:PHE252
|
3.4
|
73.9
|
1.0
|
|
SD
|
C:MET278
|
3.7
|
72.6
|
1.0
|
|
CZ
|
D:PHE252
|
3.8
|
73.9
|
1.0
|
|
CG2
|
C:THR250
|
3.8
|
73.6
|
1.0
|
|
HG21
|
C:THR250
|
3.9
|
73.6
|
1.0
|
|
C08
|
C:I34605
|
4.0
|
73.2
|
1.0
|
|
CD1
|
D:ILE221
|
4.0
|
71.9
|
1.0
|
|
C04
|
C:I34605
|
4.0
|
73.2
|
1.0
|
|
CE2
|
D:PHE252
|
4.0
|
73.9
|
1.0
|
|
CB
|
D:PRO217
|
4.1
|
70.0
|
1.0
|
|
HD12
|
D:ILE221
|
4.1
|
71.9
|
1.0
|
|
HE1
|
C:MET278
|
4.2
|
72.6
|
1.0
|
|
HB2
|
D:PRO217
|
4.3
|
70.0
|
1.0
|
|
C01
|
C:I34605
|
4.3
|
73.2
|
1.0
|
|
HB
|
C:THR250
|
4.4
|
73.6
|
1.0
|
|
CE
|
C:MET278
|
4.4
|
72.6
|
1.0
|
|
HG3
|
D:PRO217
|
4.5
|
70.0
|
1.0
|
|
HG23
|
C:THR250
|
4.5
|
73.6
|
1.0
|
|
HD13
|
D:ILE221
|
4.5
|
71.9
|
1.0
|
|
C05
|
C:I34605
|
4.5
|
73.2
|
1.0
|
|
HE2
|
C:MET278
|
4.5
|
72.6
|
1.0
|
|
HA
|
C:THR250
|
4.6
|
73.6
|
1.0
|
|
H1
|
C:I34605
|
4.7
|
73.2
|
1.0
|
|
CB
|
C:THR250
|
4.7
|
73.6
|
1.0
|
|
H3
|
C:I34605
|
4.8
|
73.2
|
1.0
|
|
H2
|
C:I34605
|
4.8
|
73.2
|
1.0
|
|
H4
|
C:I34605
|
4.8
|
73.2
|
1.0
|
|
HA
|
D:PRO217
|
4.9
|
70.0
|
1.0
|
|
CG
|
D:PRO217
|
4.9
|
70.0
|
1.0
|
|
HG13
|
D:ILE221
|
4.9
|
71.9
|
1.0
|
|
HG2
|
C:MET253
|
5.0
|
74.6
|
1.0
|
|
HG2
|
C:MET278
|
5.0
|
72.6
|
1.0
|
|
O11
|
C:I34605
|
5.0
|
73.2
|
1.0
|
|
Chlorine binding site 7 out
of 10 in 8v8c
Go back to
Chlorine Binding Sites List in 8v8c
Chlorine binding site 7 out
of 10 in the ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 7 of ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Cl604
b:80.2
occ:1.00
|
CL
|
D:EPJ604
|
0.0
|
80.2
|
1.0
|
|
C10
|
D:EPJ604
|
1.7
|
80.2
|
1.0
|
|
N2
|
D:EPJ604
|
2.6
|
80.2
|
1.0
|
|
C9
|
D:EPJ604
|
2.7
|
80.2
|
1.0
|
|
HB2
|
E:LEU108
|
2.8
|
79.4
|
1.0
|
|
H9
|
D:EPJ604
|
2.9
|
80.2
|
1.0
|
|
HB3
|
E:LEU108
|
3.0
|
79.4
|
1.0
|
|
H
|
E:LEU108
|
3.0
|
79.4
|
1.0
|
|
O
|
E:GLN116
|
3.2
|
80.7
|
1.0
|
|
O
|
E:ASN106
|
3.3
|
78.4
|
1.0
|
|
CB
|
E:LEU108
|
3.4
|
79.4
|
1.0
|
|
N
|
E:LEU108
|
3.5
|
79.4
|
1.0
|
|
HB2
|
D:SER149
|
3.7
|
80.4
|
1.0
|
|
HA
|
E:TYR117
|
3.7
|
77.4
|
1.0
|
|
HB3
|
D:SER149
|
3.8
|
80.4
|
1.0
|
|
HA
|
E:VAL107
|
3.8
|
79.0
|
1.0
|
|
C11
|
D:EPJ604
|
3.8
|
80.2
|
1.0
|
|
H
|
E:LEU118
|
3.9
|
78.0
|
1.0
|
|
C8
|
D:EPJ604
|
4.0
|
80.2
|
1.0
|
|
HB3
|
E:GLN116
|
4.0
|
80.7
|
1.0
|
|
CA
|
E:LEU108
|
4.1
|
79.4
|
1.0
|
|
C
|
E:GLN116
|
4.1
|
80.7
|
1.0
|
|
C
|
E:ASN106
|
4.1
|
78.4
|
1.0
|
|
HD22
|
E:LEU108
|
4.2
|
79.4
|
1.0
|
|
CB
|
D:SER149
|
4.2
|
80.4
|
1.0
|
|
C
|
E:VAL107
|
4.3
|
79.0
|
1.0
|
|
HA
|
D:SER149
|
4.3
|
80.4
|
1.0
|
|
CA
|
E:VAL107
|
4.4
|
79.0
|
1.0
|
|
HD13
|
E:LEU118
|
4.4
|
78.0
|
1.0
|
|
C7
|
D:EPJ604
|
4.5
|
80.2
|
1.0
|
|
HB2
|
E:LEU118
|
4.5
|
78.0
|
1.0
|
|
HD23
|
E:LEU108
|
4.5
|
79.4
|
1.0
|
|
CA
|
E:TYR117
|
4.5
|
77.4
|
1.0
|
|
HB2
|
E:ASN106
|
4.5
|
78.4
|
1.0
|
|
CG
|
E:LEU108
|
4.6
|
79.4
|
1.0
|
|
N
|
E:LEU118
|
4.6
|
78.0
|
1.0
|
|
HA
|
E:LEU108
|
4.6
|
79.4
|
1.0
|
|
N
|
E:TYR117
|
4.6
|
77.4
|
1.0
|
|
N
|
E:VAL107
|
4.6
|
79.0
|
1.0
|
|
CD2
|
E:LEU108
|
4.7
|
79.4
|
1.0
|
|
H11
|
D:EPJ604
|
4.7
|
80.2
|
1.0
|
|
H8
|
D:EPJ604
|
4.8
|
80.2
|
1.0
|
|
HD1
|
D:TRP148
|
4.8
|
75.5
|
1.0
|
|
CA
|
D:SER149
|
4.8
|
80.4
|
1.0
|
|
HG2
|
E:ARG78
|
4.8
|
80.7
|
1.0
|
|
HD12
|
E:LEU118
|
4.9
|
78.0
|
1.0
|
|
HB3
|
E:ASN106
|
4.9
|
78.4
|
1.0
|
|
HD1
|
E:TYR117
|
5.0
|
77.4
|
1.0
|
|
CB
|
E:GLN116
|
5.0
|
80.7
|
1.0
|
|
Chlorine binding site 8 out
of 10 in 8v8c
Go back to
Chlorine Binding Sites List in 8v8c
Chlorine binding site 8 out
of 10 in the ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 8 of ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Cl601
b:72.7
occ:1.00
|
CL1
|
E:I34601
|
0.0
|
72.7
|
1.0
|
|
C20
|
E:I34601
|
1.7
|
72.7
|
1.0
|
|
C19
|
E:I34601
|
2.7
|
72.7
|
1.0
|
|
HE3
|
D:MET278
|
2.7
|
71.8
|
1.0
|
|
C03
|
E:I34601
|
2.7
|
72.7
|
1.0
|
|
HB3
|
E:PRO217
|
2.8
|
68.9
|
1.0
|
|
H12
|
E:I34601
|
2.8
|
72.7
|
1.0
|
|
O02
|
E:I34601
|
2.9
|
72.7
|
1.0
|
|
HE1
|
D:MET278
|
2.9
|
71.8
|
1.0
|
|
HD11
|
E:ILE221
|
3.1
|
71.7
|
1.0
|
|
CE
|
D:MET278
|
3.3
|
71.8
|
1.0
|
|
HZ
|
E:PHE252
|
3.5
|
71.3
|
1.0
|
|
HG22
|
D:THR250
|
3.6
|
75.5
|
1.0
|
|
CB
|
E:PRO217
|
3.8
|
68.9
|
1.0
|
|
HE2
|
D:MET278
|
3.9
|
71.8
|
1.0
|
|
CD1
|
E:ILE221
|
4.0
|
71.7
|
1.0
|
|
C08
|
E:I34601
|
4.0
|
72.7
|
1.0
|
|
C04
|
E:I34601
|
4.0
|
72.7
|
1.0
|
|
HD12
|
E:ILE221
|
4.1
|
71.7
|
1.0
|
|
HG21
|
D:THR250
|
4.2
|
75.5
|
1.0
|
|
HB2
|
E:PRO217
|
4.3
|
68.9
|
1.0
|
|
C01
|
E:I34601
|
4.3
|
72.7
|
1.0
|
|
HG3
|
E:PRO217
|
4.3
|
68.9
|
1.0
|
|
HG13
|
E:ILE221
|
4.4
|
71.7
|
1.0
|
|
CG2
|
D:THR250
|
4.4
|
75.5
|
1.0
|
|
CZ
|
E:PHE252
|
4.5
|
71.3
|
1.0
|
|
HA
|
E:PRO217
|
4.5
|
68.9
|
1.0
|
|
C05
|
E:I34601
|
4.5
|
72.7
|
1.0
|
|
CG
|
E:PRO217
|
4.5
|
68.9
|
1.0
|
|
HE2
|
E:PHE252
|
4.5
|
71.3
|
1.0
|
|
HD13
|
E:ILE221
|
4.6
|
71.7
|
1.0
|
|
H1
|
E:I34601
|
4.7
|
72.7
|
1.0
|
|
CG1
|
E:ILE221
|
4.7
|
71.7
|
1.0
|
|
CA
|
E:PRO217
|
4.7
|
68.9
|
1.0
|
|
HG2
|
E:PRO217
|
4.7
|
68.9
|
1.0
|
|
SD
|
D:MET278
|
4.7
|
71.8
|
1.0
|
|
HB
|
D:THR250
|
4.8
|
75.5
|
1.0
|
|
H3
|
E:I34601
|
4.8
|
72.7
|
1.0
|
|
H2
|
E:I34601
|
4.8
|
72.7
|
1.0
|
|
H4
|
E:I34601
|
4.8
|
72.7
|
1.0
|
|
HG12
|
E:ILE221
|
4.8
|
71.7
|
1.0
|
|
HB3
|
D:MET278
|
4.9
|
71.8
|
1.0
|
|
CE2
|
E:PHE252
|
5.0
|
71.3
|
1.0
|
|
O11
|
E:I34601
|
5.0
|
72.7
|
1.0
|
|
Chlorine binding site 9 out
of 10 in 8v8c
Go back to
Chlorine Binding Sites List in 8v8c
Chlorine binding site 9 out
of 10 in the ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 9 of ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Cl604
b:79.2
occ:1.00
|
CL
|
E:EPJ604
|
0.0
|
79.2
|
1.0
|
|
C10
|
E:EPJ604
|
1.7
|
79.2
|
1.0
|
|
N2
|
E:EPJ604
|
2.6
|
79.2
|
1.0
|
|
HB2
|
A:LEU108
|
2.6
|
78.8
|
1.0
|
|
C9
|
E:EPJ604
|
2.7
|
79.2
|
1.0
|
|
H9
|
E:EPJ604
|
2.9
|
79.2
|
1.0
|
|
HB3
|
A:LEU108
|
3.0
|
78.8
|
1.0
|
|
H
|
A:LEU108
|
3.0
|
78.8
|
1.0
|
|
O
|
A:GLN116
|
3.1
|
77.6
|
1.0
|
|
CB
|
A:LEU108
|
3.3
|
78.8
|
1.0
|
|
N
|
A:LEU108
|
3.6
|
78.8
|
1.0
|
|
HB2
|
E:SER149
|
3.6
|
78.9
|
1.0
|
|
O
|
A:ASN106
|
3.6
|
77.6
|
1.0
|
|
HA
|
A:TYR117
|
3.7
|
76.2
|
1.0
|
|
HD13
|
A:LEU108
|
3.7
|
78.8
|
1.0
|
|
HB3
|
E:SER149
|
3.8
|
78.9
|
1.0
|
|
C11
|
E:EPJ604
|
3.8
|
79.2
|
1.0
|
|
HD13
|
A:LEU118
|
3.9
|
76.4
|
1.0
|
|
H
|
A:LEU118
|
3.9
|
76.4
|
1.0
|
|
HB3
|
A:GLN116
|
3.9
|
77.6
|
1.0
|
|
HA
|
A:VAL107
|
3.9
|
77.8
|
1.0
|
|
C8
|
E:EPJ604
|
4.0
|
79.2
|
1.0
|
|
C
|
A:GLN116
|
4.0
|
77.6
|
1.0
|
|
HD12
|
A:LEU108
|
4.0
|
78.8
|
1.0
|
|
CA
|
A:LEU108
|
4.0
|
78.8
|
1.0
|
|
HD12
|
A:LEU118
|
4.2
|
76.4
|
1.0
|
|
CB
|
E:SER149
|
4.2
|
78.9
|
1.0
|
|
CD1
|
A:LEU108
|
4.2
|
78.8
|
1.0
|
|
HB2
|
A:LEU118
|
4.4
|
76.4
|
1.0
|
|
C
|
A:VAL107
|
4.4
|
77.8
|
1.0
|
|
CG
|
A:LEU108
|
4.4
|
78.8
|
1.0
|
|
C
|
A:ASN106
|
4.4
|
77.6
|
1.0
|
|
C7
|
E:EPJ604
|
4.5
|
79.2
|
1.0
|
|
CA
|
A:TYR117
|
4.5
|
76.2
|
1.0
|
|
HA
|
E:SER149
|
4.5
|
78.9
|
1.0
|
|
CA
|
A:VAL107
|
4.5
|
77.8
|
1.0
|
|
N
|
A:LEU118
|
4.5
|
76.4
|
1.0
|
|
N
|
A:TYR117
|
4.5
|
76.2
|
1.0
|
|
CD1
|
A:LEU118
|
4.6
|
76.4
|
1.0
|
|
HG2
|
A:GLN116
|
4.6
|
77.6
|
1.0
|
|
HA
|
A:LEU108
|
4.6
|
78.8
|
1.0
|
|
H11
|
E:EPJ604
|
4.7
|
79.2
|
1.0
|
|
CB
|
A:GLN116
|
4.8
|
77.6
|
1.0
|
|
H8
|
E:EPJ604
|
4.8
|
79.2
|
1.0
|
|
HD1
|
E:TRP148
|
4.8
|
75.5
|
1.0
|
|
N
|
A:VAL107
|
4.9
|
77.8
|
1.0
|
|
HD22
|
A:LEU108
|
4.9
|
78.8
|
1.0
|
|
HB2
|
A:ASN106
|
4.9
|
77.6
|
1.0
|
|
HD1
|
A:TYR117
|
4.9
|
76.2
|
1.0
|
|
CA
|
E:SER149
|
4.9
|
78.9
|
1.0
|
|
CA
|
A:GLN116
|
5.0
|
77.6
|
1.0
|
|
Chlorine binding site 10 out
of 10 in 8v8c
Go back to
Chlorine Binding Sites List in 8v8c
Chlorine binding site 10 out
of 10 in the ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 10 of ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Cl605
b:70.0
occ:1.00
|
CL1
|
E:I34605
|
0.0
|
70.0
|
1.0
|
|
C20
|
E:I34605
|
1.7
|
70.0
|
1.0
|
|
C19
|
E:I34605
|
2.7
|
70.0
|
1.0
|
|
C03
|
E:I34605
|
2.7
|
70.0
|
1.0
|
|
H12
|
E:I34605
|
2.8
|
70.0
|
1.0
|
|
O02
|
E:I34605
|
2.9
|
70.0
|
1.0
|
|
HG22
|
E:THR250
|
3.0
|
72.2
|
1.0
|
|
HE1
|
E:MET278
|
3.0
|
70.2
|
1.0
|
|
SD
|
E:MET278
|
3.3
|
70.2
|
1.0
|
|
HZ
|
A:PHE252
|
3.3
|
70.1
|
1.0
|
|
HD11
|
A:ILE221
|
3.5
|
69.2
|
1.0
|
|
HB3
|
A:PRO217
|
3.5
|
67.1
|
1.0
|
|
CE
|
E:MET278
|
3.7
|
70.2
|
1.0
|
|
CG2
|
E:THR250
|
3.9
|
72.2
|
1.0
|
|
HB
|
E:THR250
|
3.9
|
72.2
|
1.0
|
|
HG21
|
E:THR250
|
3.9
|
72.2
|
1.0
|
|
C08
|
E:I34605
|
4.0
|
70.0
|
1.0
|
|
C04
|
E:I34605
|
4.0
|
70.0
|
1.0
|
|
HE1
|
A:PHE252
|
4.1
|
70.1
|
1.0
|
|
HE3
|
E:MET278
|
4.2
|
70.2
|
1.0
|
|
HB2
|
A:PRO217
|
4.2
|
67.1
|
1.0
|
|
CZ
|
A:PHE252
|
4.3
|
70.1
|
1.0
|
|
C01
|
E:I34605
|
4.3
|
70.0
|
1.0
|
|
CB
|
A:PRO217
|
4.3
|
67.1
|
1.0
|
|
HA
|
E:THR250
|
4.4
|
72.2
|
1.0
|
|
CD1
|
A:ILE221
|
4.4
|
69.2
|
1.0
|
|
CB
|
E:THR250
|
4.5
|
72.2
|
1.0
|
|
C05
|
E:I34605
|
4.5
|
70.0
|
1.0
|
|
HD12
|
A:ILE221
|
4.5
|
69.2
|
1.0
|
|
HE2
|
E:MET278
|
4.5
|
70.2
|
1.0
|
|
CE1
|
A:PHE252
|
4.6
|
70.1
|
1.0
|
|
H1
|
E:I34605
|
4.7
|
70.0
|
1.0
|
|
HG23
|
E:THR250
|
4.8
|
72.2
|
1.0
|
|
H3
|
E:I34605
|
4.8
|
70.0
|
1.0
|
|
H2
|
E:I34605
|
4.8
|
70.0
|
1.0
|
|
HB3
|
E:MET253
|
4.8
|
69.1
|
1.0
|
|
H4
|
E:I34605
|
4.8
|
70.0
|
1.0
|
|
HG13
|
A:ILE221
|
5.0
|
69.2
|
1.0
|
|
O11
|
E:I34605
|
5.0
|
70.0
|
1.0
|
|
Reference:
S.M.Burke,
M.Avstrikova,
C.M.Noviello,
N.Mukhtasimova,
J.P.Changeux,
G.A.Thakur,
S.M.Sine,
M.Cecchini,
R.E.Hibbs.
ALPHA7-Nicotinic Acetylcholine Receptor Time Resolved Bound to Epibatidine and Pnu-120596 Asymmetric State 1 To Be Published.
Page generated: Tue Jul 30 13:32:07 2024
|
