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Chlorine in PDB 8vmg: Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435

Enzymatic activity of Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435

All present enzymatic activity of Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435:
2.7.11.1; 2.7.11.26;

Protein crystallography data

The structure of Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435, PDB code: 8vmg was solved by M.D.Enos, M.Gavagan, N.Jameson, J.G.Zalatan, W.I.Weis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.76 / 2.45
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 195.585, 195.585, 152.204, 90, 90, 120
R / Rfree (%) 19.5 / 23

Other elements in 8vmg:

The structure of Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435 also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Chlorine Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 15;

Binding sites:

The binding sites of Chlorine atom in the Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435 (pdb code 8vmg). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 15 binding sites of Chlorine where determined in the Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435, PDB code: 8vmg:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 15 in 8vmg

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Chlorine binding site 1 out of 15 in the Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl437

b:85.6
occ:1.00
 NE2 C:GLN400 3.5 69.2 1.0
N A:GLN295 3.5 60.1 1.0
CA A:PRO294 4.0 62.2 1.0
CB A:GLN295 4.2 58.4 1.0
C A:PRO294 4.3 59.0 1.0
CG A:GLN295 4.3 61.4 1.0
CA A:GLN295 4.4 58.3 1.0
CD C:GLN400 4.6 74.2 1.0
CB A:PRO294 4.6 59.4 1.0
OE1 C:GLN400 4.7 73.9 1.0
O A:GLN295 4.7 67.0 1.0

Chlorine binding site 2 out of 15 in 8vmg

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Chlorine binding site 2 out of 15 in the Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl438

b:79.6
occ:1.00
 O A:HOH574 3.3 70.7 1.0
NZ A:LYS183 3.7 68.7 1.0
CG A:GLN185 3.9 60.4 1.0
CB A:GLN185 3.9 57.7 1.0
O A:HOH561 4.0 82.3 1.0
O A:HOH558 4.1 82.6 1.0
CD A:GLN185 4.6 59.7 1.0
MG A:MG436 4.7 73.5 1.0
CD A:LYS183 4.7 62.6 1.0
CE A:LYS183 4.8 65.9 1.0
O3 A:SO4434 4.8 95.0 1.0

Chlorine binding site 3 out of 15 in 8vmg

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Chlorine binding site 3 out of 15 in the Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl439

b:106.6
occ:1.00
 N A:ARG209 3.5 77.8 1.0
CG A:ARG209 3.7 110.8 1.0
CB A:ARG209 4.1 93.8 1.0
CG1 A:VAL208 4.1 78.9 1.0
CA A:VAL208 4.1 75.2 1.0
CD A:ARG209 4.3 125.2 1.0
C A:VAL208 4.3 77.6 1.0
CA A:ARG209 4.4 85.2 1.0
O A:LEU207 4.6 70.9 1.0
CB A:VAL208 4.7 80.6 1.0

Chlorine binding site 4 out of 15 in 8vmg

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Chlorine binding site 4 out of 15 in the Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl440

b:117.5
occ:1.00
 NH2 A:ARG278 3.1 95.3 1.0
NH1 A:ARG282 3.4 108.2 1.0
NH2 A:ARG282 3.8 100.2 1.0
CZ A:ARG282 4.1 110.9 1.0
CZ A:ARG278 4.3 99.8 1.0
NE A:ARG278 4.8 86.1 1.0

Chlorine binding site 5 out of 15 in 8vmg

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Chlorine binding site 5 out of 15 in the Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl441

b:79.0
occ:1.00
 OE1 A:GLU322 3.4 63.8 1.0
NE2 A:GLN280 3.5 50.2 1.0
CD2 A:TYR323 3.6 50.6 1.0
N A:TYR323 3.7 44.0 1.0
CA A:GLU322 4.0 51.0 1.0
O A:LEU321 4.1 49.5 1.0
CE2 A:TYR323 4.3 56.4 1.0
CG A:TYR323 4.4 50.8 1.0
C A:GLU322 4.4 49.2 1.0
CD A:GLU322 4.5 67.9 1.0
CB A:TYR323 4.5 49.0 1.0
CD A:GLN280 4.6 60.2 1.0
O A:HOH580 4.6 57.6 1.0
CB A:GLU322 4.7 49.2 1.0
CA A:TYR323 4.7 50.4 1.0
CD1 A:LEU273 4.8 50.0 1.0
OE1 A:GLN280 4.9 60.1 1.0
CB A:LEU273 4.9 47.0 1.0
C A:LEU321 5.0 49.2 1.0
N A:GLU322 5.0 45.6 1.0

Chlorine binding site 6 out of 15 in 8vmg

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Chlorine binding site 6 out of 15 in the Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl423

b:102.8
occ:1.00
 N B:PHE360 3.4 83.8 1.0
N B:LEU359 3.4 88.2 1.0
CA B:ALA358 3.7 91.4 1.0
CB B:ALA358 4.0 83.2 1.0
CD2 B:PHE360 4.0 88.4 1.0
N B:ASN361 4.0 92.3 1.0
C B:ALA358 4.0 87.2 1.0
CA B:PHE360 4.1 89.2 1.0
CB B:PHE360 4.2 89.1 1.0
C B:PHE360 4.2 93.3 1.0
C B:LEU359 4.3 78.0 1.0
CG B:PHE360 4.4 81.9 1.0
CA B:LEU359 4.4 76.9 1.0
OD1 B:ASN361 4.6 96.3 1.0
CB B:ASN361 4.6 103.3 1.0
CG B:ASN361 4.7 101.5 1.0
CE2 B:PHE360 4.8 91.8 1.0
CA B:ASN361 4.9 98.0 1.0
N B:ALA358 5.0 90.5 1.0

Chlorine binding site 7 out of 15 in 8vmg

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Chlorine binding site 7 out of 15 in the Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl424

b:120.4
occ:1.00
 NH2 B:ARG306 3.3 133.8 1.0
N B:THR152 3.5 92.1 1.0
CG2 B:THR152 3.5 90.6 1.0
CB B:THR152 4.0 98.2 1.0
CA B:GLN151 4.2 90.8 1.0
CA B:THR152 4.3 95.9 1.0
C B:GLN151 4.4 83.6 1.0
CB B:GLN151 4.4 91.8 1.0
O B:THR152 4.6 85.9 1.0
CZ B:ARG306 4.6 126.3 1.0
CG B:GLN151 4.9 102.7 1.0
C B:THR152 4.9 85.6 1.0
HO2 B:EDO402 4.9 102.7 1.0

Chlorine binding site 8 out of 15 in 8vmg

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Chlorine binding site 8 out of 15 in the Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl425

b:87.4
occ:1.00
 N B:ARG308 3.5 62.0 1.0
CB B:ARG308 3.5 71.7 1.0
CD B:ARG308 3.6 98.8 1.0
CG B:ARG308 3.6 81.5 1.0
CG B:PRO307 3.8 63.9 1.0
CD B:PRO307 3.8 56.1 1.0
N B:PRO307 4.0 61.0 1.0
CB B:ARG306 4.1 63.4 1.0
NE B:ARG306 4.1 113.9 1.0
CA B:ARG308 4.2 63.0 1.0
NE B:ARG308 4.2 123.6 1.0
CD B:ARG306 4.3 101.2 1.0
CZ B:ARG306 4.4 126.3 1.0
C B:PRO307 4.5 63.0 1.0
C B:ARG306 4.5 66.3 1.0
CB B:PRO307 4.6 64.3 1.0
CA B:PRO307 4.6 74.3 1.0
CZ B:ARG308 4.8 131.8 1.0
NH2 B:ARG306 4.8 133.8 1.0
NH1 B:ARG306 4.8 106.3 1.0
CG B:ARG306 4.8 104.1 1.0
NH1 B:ARG308 4.9 127.4 1.0
CA B:ARG306 4.9 63.0 1.0

Chlorine binding site 9 out of 15 in 8vmg

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Chlorine binding site 9 out of 15 in the Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl426

b:123.2
occ:1.00
 OD2 B:ASP233 3.0 102.4 1.0
O B:GLU283 3.6 81.0 1.0
CG B:ASP233 3.7 95.7 1.0
OD1 B:ASP233 3.9 89.0 1.0
O B:MET284 4.3 75.6 1.0
C B:GLU283 4.6 84.9 1.0
CD B:PRO286 4.7 100.4 1.0
O B:ARG282 4.7 102.4 1.0
CB B:ASP233 4.8 84.2 1.0
CG B:PRO286 4.8 107.0 1.0
O B:ASP233 4.9 83.3 1.0
C B:MET284 5.0 86.5 1.0

Chlorine binding site 10 out of 15 in 8vmg

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Chlorine binding site 10 out of 15 in the Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Crystal Structure of Gsk-3 26-383 Bound to Axin 383-435 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl427

b:105.0
occ:1.00
 N B:GLN295 3.9 102.1 1.0
NE2 D:GLN400 3.9 121.7 1.0
CA B:PRO294 4.4 99.8 1.0
CB B:GLN295 4.4 100.4 1.0
C B:PRO294 4.7 103.9 1.0
CA B:GLN295 4.7 104.4 1.0
CG B:GLN295 4.7 101.1 1.0
O B:GLN295 4.8 95.2 1.0
CB B:PRO294 4.8 100.2 1.0
OE1 D:GLN400 4.8 123.7 1.0
CD D:GLN400 4.9 116.8 1.0

Reference:

M.D.Enos, M.Gavagan, N.Jameson, J.G.Zalatan, W.I.Weis. Structural and Functional Effects of Phosphopriming and Scaffolding in the Kinase GSK3BETA Sci.Signal. 2024.
ISSN: ESSN 1937-9145
DOI: 10.1126/SCISIGNAL.ADO0881
Page generated: Sat Sep 28 19:35:02 2024

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