Chlorine in PDB 8vpp: Phosphorylated Human Ncc in Complex with Chlorthalidone

The binding sites of Chlorine atom in the Phosphorylated Human Ncc in Complex with Chlorthalidone (pdb code 8vpp). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Phosphorylated Human Ncc in Complex with Chlorthalidone, PDB code: 8vpp:

Chlorine binding site 1 out of 1 in the Phosphorylated Human Ncc in Complex with Chlorthalidone


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Phosphorylated Human Ncc in Complex with Chlorthalidone within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1101 b:93.7 occ:1.00 CL1 A:KLT1101 0.0 93.7 1.0 C3 A:KLT1101 1.8 66.4 1.0 OH A:TYR539 2.5 76.9 1.0 C4 A:KLT1101 2.7 72.2 1.0 C1 A:KLT1101 2.8 67.8 1.0 CE1 A:TYR539 2.8 67.1 1.0 H4 A:KLT1101 2.8 73.8 1.0 CZ A:TYR539 3.1 68.2 1.0 O1 A:KLT1101 3.1 62.8 1.0 S1 A:KLT1101 3.3 69.2 1.0 O2 A:KLT1101 3.4 86.7 1.0 O A:THR351 3.5 76.6 1.0 CD1 A:LEU354 3.5 62.9 1.0 CG A:LEU354 3.6 60.2 1.0 CD1 A:PHE535 3.9 68.1 1.0 CZ A:PHE222 4.0 58.7 1.0 C5 A:KLT1101 4.0 77.9 1.0 C2 A:KLT1101 4.1 66.5 1.0 CD1 A:TYR539 4.1 67.5 1.0 CA A:GLY352 4.3 64.8 1.0 N A:ILE353 4.3 53.5 1.0 CE1 A:PHE222 4.3 63.5 1.0 CB A:LEU354 4.3 57.4 1.0 CE2 A:TYR539 4.4 64.9 1.0 C A:THR351 4.4 72.5 1.0 CE1 A:PHE535 4.4 58.7 1.0 N A:LEU354 4.5 68.5 1.0 CG A:PHE535 4.5 66.2 1.0 C6 A:KLT1101 4.5 74.8 1.0 CB A:PHE535 4.7 58.5 1.0 C A:GLY352 4.7 66.1 1.0 N A:GLY352 4.8 67.2 1.0 CD2 A:LEU354 4.8 61.6 1.0 H5 A:KLT1101 4.9 74.5 1.0 H2 A:KLT1101 4.9 73.1 1.0 N1 A:KLT1101 4.9 72.2 1.0

Y.Zhao, H.Schubert, A.Blakely, B.Forbush, M.D.Smith, J.Rinehart, E.Cao. Structural Bases For Na + -Cl - Cotransporter Inhibition By Thiazide Diuretic Drugs and Activation By Kinases. Nat Commun V. 15 7006 2024.
ISSN: ESSN 2041-1723
PubMed: 39143061
DOI: 10.1038/S41467-024-51381-Y