Chlorine in PDB 8vtp: Structure of FABS1CE-Epr-1, A High Affinity Antibody For the Erythropoeitin Receptor

The structure of Structure of FABS1CE-Epr-1, A High Affinity Antibody For the Erythropoeitin Receptor, PDB code: 8vtp was solved by A.U.Singer, H.A.Bruce, L.Blazer, J.J.Adams, S.S.Sidhu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	64.79 / 1.77
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	66.75, 72.938, 129.581, 90, 90, 90
R / Rfree (%)	17.5 / 19.5

The structure of Structure of FABS1CE-Epr-1, A High Affinity Antibody For the Erythropoeitin Receptor also contains other interesting chemical elements:

Sodium

(Na)

5 atoms

The binding sites of Chlorine atom in the Structure of FABS1CE-Epr-1, A High Affinity Antibody For the Erythropoeitin Receptor (pdb code 8vtp). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Structure of FABS1CE-Epr-1, A High Affinity Antibody For the Erythropoeitin Receptor, PDB code: 8vtp:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Structure of FABS1CE-Epr-1, A High Affinity Antibody For the Erythropoeitin Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of FABS1CE-Epr-1, A High Affinity Antibody For the Erythropoeitin Receptor within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl308 b:66.3 occ:1.00 O A:HOH515 3.1 42.7 1.0 N A:THR65 3.2 30.4 1.0 OG1 A:THR65 3.4 32.0 1.0 O A:HOH522 3.6 46.7 1.0 CA A:TYR64 3.7 27.6 1.0 O A:THR65 3.8 33.1 1.0 C A:TYR64 4.0 30.1 1.0 CA A:THR65 4.2 28.6 1.0 CD1 A:TYR64 4.2 30.7 1.0 CB A:TYR64 4.3 27.4 1.0 CB A:THR65 4.3 29.1 1.0 C A:THR65 4.5 32.7 1.0 O A:SER63 4.5 31.9 1.0 CG A:TYR64 4.8 30.1 1.0 N A:TYR64 4.9 30.1 1.0 CG2 A:THR65 4.9 29.7 1.0

Chlorine binding site 2 out of 3 in the Structure of FABS1CE-Epr-1, A High Affinity Antibody For the Erythropoeitin Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of FABS1CE-Epr-1, A High Affinity Antibody For the Erythropoeitin Receptor within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl309 b:54.0 occ:1.00 N A:THR174 2.9 36.0 1.0 N A:SER175 3.0 36.7 1.0 O A:HOH569 3.2 51.2 1.0 OG1 A:THR174 3.4 44.3 1.0 OG A:SER175 3.5 59.1 1.0 O A:ALA172 3.7 41.9 1.0 CB A:SER175 3.8 55.0 1.0 CA A:LEU173 3.8 38.8 1.0 CA A:THR174 3.8 39.9 1.0 C A:LEU173 3.8 34.2 1.0 C A:THR174 3.9 35.0 1.0 CA A:SER175 4.0 35.9 1.0 CD1 A:LEU173 4.0 36.9 1.0 CB A:THR174 4.2 42.2 1.0 O A:HOH414 4.3 55.8 1.0 C A:ALA172 4.6 39.9 1.0 N A:LEU173 4.6 34.5 1.0 O A:SER175 4.8 37.1 1.0 CB A:LEU173 4.8 31.9 1.0 CG A:LEU173 4.9 31.7 1.0 CG2 A:THR174 4.9 40.4 1.0 C A:SER175 4.9 38.3 1.0

Chlorine binding site 3 out of 3 in the Structure of FABS1CE-Epr-1, A High Affinity Antibody For the Erythropoeitin Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of FABS1CE-Epr-1, A High Affinity Antibody For the Erythropoeitin Receptor within 5.0Å range: probe atom residue distance (Å) B Occ G:Cl316 b:64.9 occ:1.00 N G:SER176 3.3 40.2 1.0 O G:SER176 3.5 42.2 1.0 OE1 G:GLN175 3.8 41.8 1.0 CA G:GLN175 3.8 35.1 1.0 OG G:SER176 4.0 61.9 1.0 C G:GLN175 4.1 40.3 1.0 CD G:GLN175 4.1 42.6 1.0 O G:LEU174 4.3 42.0 1.0 C G:SER176 4.3 42.4 1.0 CA G:SER176 4.3 37.8 1.0 ND2 G:ASN178 4.3 37.2 1.0 CB G:GLN175 4.4 34.7 1.0 NE2 G:GLN175 4.4 39.5 1.0 O2 G:EDO304 4.8 61.3 1.0 O1 G:EDO304 4.8 60.4 1.0 CG G:ASN178 4.8 39.1 1.0 OD1 G:ASN178 4.8 37.4 1.0 CB G:SER176 4.8 45.2 1.0 N G:GLN175 4.9 38.6 1.0 CG G:GLN175 4.9 39.4 1.0

H.A.Bruce, A.U.Singer, L.L.Blazer, K.Luu, L.Ploder, A.Pavlenco, I.Kurinov, J.J.Adams, S.S.Sidhu. Antigen-Binding Fragments with Improved Crystal Lattice Packing and Enhanced Conformational Flexibility at the Elbow Region As Crystallization Chaperones. Protein Sci. V. 33 E5081 2024.
ISSN: ESSN 1469-896X
PubMed: 38924648
DOI: 10.1002/PRO.5081