Chlorine in PDB 8vu4: Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor

Protein crystallography data

The structure of Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor, PDB code: 8vu4 was solved by A.U.Singer, H.A.Bruce, A.Pavlenco, L.Ploder, G.Luu, L.Blazer, J.J.Adams, S.S.Sidhu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.40 / 2.35
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 55.863, 55.893, 87.016, 80.05, 89.91, 82.7
R / Rfree (%) 20.8 / 25.2

Other elements in 8vu4:

The structure of Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor also contains other interesting chemical elements:

Sodium (Na) 14 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor (pdb code 8vu4). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 8 binding sites of Chlorine where determined in the Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor, PDB code: 8vu4:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Chlorine binding site 1 out of 8 in 8vu4

Go back to Chlorine Binding Sites List in 8vu4
Chlorine binding site 1 out of 8 in the Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl303

b:71.1
occ:1.00
 N B:THR207 2.9 50.2 1.0
OG1 B:THR207 3.0 47.4 1.0
O B:THR205 3.3 63.1 1.0
CB B:THR207 3.3 46.3 1.0
C B:GLN206 3.7 54.8 1.0
CA B:THR207 3.7 52.0 1.0
CA B:GLN206 3.7 54.8 1.0
C B:THR205 4.2 59.4 1.0
NE2 B:GLN206 4.3 44.9 1.0
N B:GLN206 4.4 60.0 1.0
CD B:GLN206 4.4 54.4 1.0
OE1 B:GLN206 4.6 59.0 1.0
CG2 B:THR207 4.7 44.9 1.0
C B:THR207 4.8 49.9 1.0
O B:GLN206 4.8 50.2 1.0
O B:THR207 4.8 46.3 1.0
CB B:GLN206 4.8 47.1 1.0

Chlorine binding site 2 out of 8 in 8vu4

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Chlorine binding site 2 out of 8 in the Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl301

b:62.3
occ:1.00
 N C:SER176 3.3 47.9 1.0
O C:SER176 3.4 50.5 1.0
OG C:SER176 3.7 64.7 1.0
CA C:GLN175 3.9 44.5 1.0
ND2 C:ASN178 4.0 48.2 1.0
OE1 C:GLN175 4.0 46.2 1.0
C C:GLN175 4.1 46.5 1.0
C C:SER176 4.1 53.4 1.0
CA C:SER176 4.2 48.5 1.0
CD C:GLN175 4.3 48.8 1.0
CG C:ASN178 4.4 43.0 1.0
OD1 C:ASN178 4.5 40.6 1.0
O C:LEU174 4.5 41.7 1.0
NE2 C:GLN175 4.5 44.6 1.0
CB C:GLN175 4.5 41.9 1.0
CB C:SER176 4.6 47.0 1.0
OG G:SER9 4.7 53.5 1.0
CB G:SER9 4.7 50.2 1.0

Chlorine binding site 3 out of 8 in 8vu4

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Chlorine binding site 3 out of 8 in the Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl302

b:70.0
occ:1.00
 O C:HOH453 3.2 58.7 1.0
N C:GLY47 3.7 55.9 1.0
O B:HOH410 3.8 41.6 1.0
NE2 C:GLN44 3.9 41.3 1.0
OE1 B:GLN44 4.0 46.6 1.0
CD C:GLN44 4.2 43.3 1.0
CA C:GLY47 4.4 47.7 1.0
OE1 C:GLN44 4.4 44.1 1.0
CD B:GLN44 4.5 44.4 1.0
NE2 B:GLN44 4.5 49.5 1.0
O C:LYS45 4.5 48.9 1.0
O C:HOH421 4.6 47.3 1.0
CA C:PRO46 4.6 58.2 1.0
C C:PRO46 4.7 57.5 1.0
O C:LYS48 4.7 42.1 1.0
N C:LYS48 4.7 49.8 1.0
OH B:TYR103 4.8 54.1 1.0
CG C:GLN44 4.9 46.4 1.0
C C:GLY47 5.0 50.7 1.0

Chlorine binding site 4 out of 8 in 8vu4

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Chlorine binding site 4 out of 8 in the Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl303

b:63.1
occ:1.00
 CD C:PRO133 3.8 36.3 1.0
CG2 C:VAL223 4.0 37.6 1.0
OE1 C:GLN218 4.2 44.9 1.0
CG C:PRO133 4.2 45.3 1.0
CG2 C:THR221 4.2 40.8 1.0
O C:VAL216 4.2 35.4 1.0
CB C:GLN218 4.5 53.9 1.0
O C:THR221 4.5 39.1 1.0
CB C:ALA132 4.5 43.8 1.0
CB C:VAL223 4.5 38.6 1.0
CG1 C:VAL216 4.6 36.2 1.0
CB C:THR221 4.7 47.8 1.0
N C:VAL223 4.9 35.2 1.0
N C:PRO133 4.9 44.5 1.0
C C:THR221 5.0 43.0 1.0
CA C:ALA132 5.0 42.9 1.0

Chlorine binding site 5 out of 8 in 8vu4

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Chlorine binding site 5 out of 8 in the Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl304

b:78.4
occ:1.00
 OE1 C:GLN175 3.3 46.2 1.0
NE2 C:GLN175 4.0 44.6 1.0
CD C:GLN175 4.0 48.8 1.0
CD2 C:LEU201 4.1 47.7 1.0
OD2 C:ASP205 4.4 68.5 1.0
CE1 C:HIS209 4.5 59.1 1.0
ND2 C:ASN178 4.7 48.2 1.0
CG C:ASP205 4.8 68.3 1.0
ND1 C:HIS209 4.8 57.1 1.0
CB C:VAL170 4.9 47.0 1.0
CG1 C:VAL170 4.9 47.2 1.0
NE2 G:GLN120 4.9 77.1 1.0
O G:HOH401 4.9 65.7 1.0
CG2 C:VAL170 4.9 47.2 1.0
O C:HOH438 4.9 53.7 1.0
CB C:ASP205 5.0 56.9 1.0

Chlorine binding site 6 out of 8 in 8vu4

Go back to Chlorine Binding Sites List in 8vu4
Chlorine binding site 6 out of 8 in the Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl305

b:69.9
occ:1.00
 N C:ALA132 3.0 44.1 1.0
CA C:ALA131 3.6 51.5 1.0
C C:ALA131 3.8 41.6 1.0
CB C:ALA132 3.9 43.8 1.0
CA C:ALA132 4.0 42.9 1.0
O C:VAL130 4.1 51.1 1.0
N C:ALA131 4.4 45.4 1.0
CB C:ALA131 4.5 44.0 1.0
C C:VAL130 4.6 47.9 1.0
O C:ALA132 4.7 45.6 1.0
C C:ALA132 4.9 44.2 1.0
O C:ALA131 5.0 44.9 1.0

Chlorine binding site 7 out of 8 in 8vu4

Go back to Chlorine Binding Sites List in 8vu4
Chlorine binding site 7 out of 8 in the Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl301

b:65.5
occ:1.00
 O A:ASP222 3.8 40.2 1.0
CB A:ASP222 3.9 35.6 1.0
C A:ASP222 4.0 40.8 1.0
CD1 A:ILE209 4.1 41.1 1.0
N A:LYS224 4.3 38.8 1.0
CG2 A:ILE209 4.4 41.5 1.0
N A:LYS223 4.4 43.5 1.0
CA A:ASP222 4.6 37.9 1.0
CB A:LYS224 4.6 42.1 1.0
C A:LYS223 4.7 40.7 1.0
CA A:LYS223 4.7 37.9 1.0
CG1 A:ILE209 4.9 44.6 1.0
CA A:LYS224 5.0 39.7 1.0

Chlorine binding site 8 out of 8 in 8vu4

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Chlorine binding site 8 out of 8 in the Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Structure of FABS1CE4-Epr-1, An Elbow-Locked High Affinity Antibody For the Erythropoeitin Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Cl304

b:66.2
occ:1.00
 CB G:GLN218 3.5 47.2 1.0
OE1 G:GLN218 3.6 46.3 1.0
O G:VAL216 3.9 38.7 1.0
CD G:PRO133 3.9 50.3 1.0
N G:GLN218 4.1 47.0 1.0
O G:THR221 4.1 39.5 1.0
CG G:PRO133 4.2 49.4 1.0
CG1 G:VAL216 4.2 39.0 1.0
CD G:GLN218 4.4 50.3 1.0
CA G:GLN218 4.4 43.9 1.0
CG2 G:THR221 4.5 39.8 1.0
O G:GLN218 4.5 45.2 1.0
C G:VAL216 4.5 42.1 1.0
CG G:GLN218 4.5 50.6 1.0
C G:THR217 4.6 46.6 1.0
C G:THR221 4.7 42.3 1.0
CG2 G:VAL223 4.7 31.5 1.0
CB G:THR221 4.8 44.6 1.0
CA G:THR217 4.9 44.9 1.0
N G:THR217 5.0 43.2 1.0
CB G:VAL223 5.0 35.0 1.0
N G:VAL223 5.0 33.3 1.0
CB G:VAL216 5.0 35.7 1.0
C G:GLN218 5.0 41.8 1.0

Reference:

H.A.Bruce, A.U.Singer, L.L.Blazer, K.Luu, L.Ploder, A.Pavlenco, I.Kurinov, J.J.Adams, S.S.Sidhu. Antigen-Binding Fragments with Improved Crystal Lattice Packing and Enhanced Conformational Flexibility at the Elbow Region As Crystallization Chaperones. Protein Sci. V. 33 E5081 2024.
ISSN: ESSN 1469-896X
PubMed: 38924648
DOI: 10.1002/PRO.5081
Page generated: Tue Jul 30 13:42:49 2024

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