Chlorine in PDB 8w9a: Cryoem Structure of Human PI3K-Alpha (P85/P110-H1047R) with Qr-7909 Binding at An Allosteric Site

All present enzymatic activity of Cryoem Structure of Human PI3K-Alpha (P85/P110-H1047R) with Qr-7909 Binding at An Allosteric Site:
2.7.1.137; 2.7.1.153; 2.7.11.1;

The binding sites of Chlorine atom in the Cryoem Structure of Human PI3K-Alpha (P85/P110-H1047R) with Qr-7909 Binding at An Allosteric Site (pdb code 8w9a). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Cryoem Structure of Human PI3K-Alpha (P85/P110-H1047R) with Qr-7909 Binding at An Allosteric Site, PDB code: 8w9a:

Chlorine binding site 1 out of 1 in the Cryoem Structure of Human PI3K-Alpha (P85/P110-H1047R) with Qr-7909 Binding at An Allosteric Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryoem Structure of Human PI3K-Alpha (P85/P110-H1047R) with Qr-7909 Binding at An Allosteric Site within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1101 b:14.9 occ:1.00 CL08 A:UEX1101 0.0 14.9 1.0 C07 A:UEX1101 1.8 14.9 1.0 N09 A:UEX1101 2.7 14.9 1.0 C06 A:UEX1101 2.7 14.9 1.0 H061 A:UEX1101 2.8 14.9 1.0 CE1 A:TYR985 3.3 7.0 1.0 CB A:CYS984 3.4 7.1 1.0 CG A:GLN981 3.5 10.9 1.0 CA A:GLN981 3.5 10.9 1.0 O A:GLN981 3.7 10.9 1.0 CB A:GLN981 3.7 10.9 1.0 CZ A:TYR985 3.8 7.0 1.0 CD1 A:TYR985 3.9 7.0 1.0 C10 A:UEX1101 3.9 14.9 1.0 OH A:TYR985 4.0 7.0 1.0 C05 A:UEX1101 4.0 14.9 1.0 SG A:CYS984 4.0 7.1 1.0 C A:GLN981 4.1 10.9 1.0 CE2 A:PHE1039 4.2 10.6 1.0 C04 A:UEX1101 4.5 14.9 1.0 CD A:GLN981 4.5 10.9 1.0 CA A:CYS984 4.6 7.1 1.0 N A:GLN981 4.6 10.9 1.0 CE2 A:TYR985 4.7 7.0 1.0 O A:PHE980 4.7 11.2 1.0 H051 A:UEX1101 4.7 14.9 1.0 CG A:TYR985 4.8 7.0 1.0 N A:TYR985 4.8 7.0 1.0 NE2 A:GLN981 4.8 10.9 1.0 CZ A:PHE1039 4.9 10.6 1.0 C A:CYS984 4.9 7.1 1.0 CG A:MET1043 5.0 12.9 1.0

X.Huang, K.Wang, J.Han, X.Chen, Z.Wang, T.Wu, B.Yu, F.Zhao, X.Wang, H.Li, Z.Xie, X.Zhu, W.Zhong, X.Ren. Cryo-Em Structures Reveal Two Allosteric Inhibition Modes of PI3K Alpha H1047R Involving A Re-Shaping of the Activation Loop. Structure 2024.
ISSN: ISSN 0969-2126
PubMed: 38582077
DOI: 10.1016/J.STR.2024.03.007