Chlorine in PDB 8wtx: Cryo-Em Structure of Noradrenaline Transporter in Complex with Bupropion

The binding sites of Chlorine atom in the Cryo-Em Structure of Noradrenaline Transporter in Complex with Bupropion (pdb code 8wtx). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Cryo-Em Structure of Noradrenaline Transporter in Complex with Bupropion, PDB code: 8wtx:

Chlorine binding site 1 out of 1 in the Cryo-Em Structure of Noradrenaline Transporter in Complex with Bupropion


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Noradrenaline Transporter in Complex with Bupropion within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl701 b:72.4 occ:1.00 CL1 A:Y60701 0.0 72.4 1.0 C6 A:Y60701 1.8 54.3 1.0 C7 A:Y60701 2.8 52.8 1.0 C5 A:Y60701 2.8 54.0 1.0 CA A:SER420 3.6 25.4 1.0 O A:SER419 3.8 34.3 1.0 OG A:SER420 3.8 35.7 1.0 CB A:TYR152 4.0 25.0 1.0 N A:SER420 4.0 31.6 1.0 C8 A:Y60701 4.0 53.8 1.0 C4 A:Y60701 4.1 58.4 1.0 CA A:GLY149 4.1 15.8 1.0 CD2 A:TYR152 4.1 26.7 1.0 C A:SER419 4.1 36.2 1.0 CG A:TYR152 4.2 26.6 1.0 CB A:SER420 4.3 29.6 1.0 N A:GLY149 4.5 20.1 1.0 O A:SER420 4.5 37.7 1.0 C A:SER420 4.5 31.1 1.0 C9 A:Y60701 4.6 55.3 1.0 CA A:GLY423 4.7 34.4 1.0 O A:VAL148 4.7 29.4 1.0 C A:VAL148 4.8 22.2 1.0 CG1 A:VAL148 4.9 18.6 1.0 CE2 A:TYR152 4.9 34.3 1.0 N A:GLY423 5.0 38.8 1.0

T.Hu, Z.Yu, J.Zhao, Y.Meng, K.Salomon, Q.Bai, Y.Wei, J.Zhang, S.Xu, Q.Dai, R.Yu, B.Yang, C.J.Loland, Y.Zhao. Transport and Inhibition Mechanisms of the Human Noradrenaline Transporter. Nature 2024.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-024-07638-Z