Chlorine in PDB 8x7e: Crystal Structure of the Mutant Human Ror Gamma Ligand Binding Domain with Jte-151
Protein crystallography data
The structure of Crystal Structure of the Mutant Human Ror Gamma Ligand Binding Domain with Jte-151, PDB code: 8x7e
was solved by
S.Akai,
A.Nomura,
K.Yamaguchi,
T.Adachi,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 38.34 / 2.30 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 90.45, 79.2, 97.24, 90, 115.67, 90 |
| R / Rfree (%) | 21.9 / 26.3 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the Mutant Human Ror Gamma Ligand Binding Domain with Jte-151
(pdb code 8x7e). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of the Mutant Human Ror Gamma Ligand Binding Domain with Jte-151, PDB code: 8x7e:
Jump to Chlorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Chlorine where determined in the Crystal Structure of the Mutant Human Ror Gamma Ligand Binding Domain with Jte-151, PDB code: 8x7e:
Jump to Chlorine binding site number: 1; 2; 3; 4;
Chlorine binding site 1 out of 4 in 8x7e
Go back to
Chlorine Binding Sites List in 8x7e
Chlorine binding site 1 out
of 4 in the Crystal Structure of the Mutant Human Ror Gamma Ligand Binding Domain with Jte-151
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of the Mutant Human Ror Gamma Ligand Binding Domain with Jte-151 within 5.0Å range:
|
Chlorine binding site 2 out of 4 in 8x7e
Go back to
Chlorine Binding Sites List in 8x7e
Chlorine binding site 2 out
of 4 in the Crystal Structure of the Mutant Human Ror Gamma Ligand Binding Domain with Jte-151
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of the Mutant Human Ror Gamma Ligand Binding Domain with Jte-151 within 5.0Å range:
|
Chlorine binding site 3 out of 4 in 8x7e
Go back to
Chlorine Binding Sites List in 8x7e
Chlorine binding site 3 out
of 4 in the Crystal Structure of the Mutant Human Ror Gamma Ligand Binding Domain with Jte-151
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Crystal Structure of the Mutant Human Ror Gamma Ligand Binding Domain with Jte-151 within 5.0Å range:
|
Chlorine binding site 4 out of 4 in 8x7e
Go back to
Chlorine Binding Sites List in 8x7e
Chlorine binding site 4 out
of 4 in the Crystal Structure of the Mutant Human Ror Gamma Ligand Binding Domain with Jte-151
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Crystal Structure of the Mutant Human Ror Gamma Ligand Binding Domain with Jte-151 within 5.0Å range:
|
Reference:
T.Maeba,
K.Hirata,
M.Kotoku,
N.Seki,
K.Maeda,
S.Hirashima,
H.Yamanaka,
T.Sakai,
S.Obika,
A.Hori,
Y.Hara,
S.Noji,
Y.Suwa,
M.Yokota,
S.Fujioka,
T.Yamaguchi,
Y.Katsuda,
T.Hata,
N.Miyagawa,
K.Arita,
Y.Nomura,
T.Taniguchi,
K.Asahina,
Y.Aratsu,
Y.Naka,
T.Adachi,
A.Nomura,
S.Akai,
S.I.Oshida,
S.Pai,
P.Crowe,
E.Bradley,
R.Steensma,
H.Tao,
M.Fenn,
R.Babine,
X.Li,
S.Thacher,
T.Soeta,
Y.Ukaji,
M.Shiozaki.
Discovery and Sar of Jte-151: A Novel Ror Gamma Inhibitor For Clinical Development. J.Med.Chem. V. 67 952 2024.
ISSN: ISSN 0022-2623
PubMed: 38170624
DOI: 10.1021/ACS.JMEDCHEM.3C01933
Page generated: Tue Dec 10 19:28:23 2024
ISSN: ISSN 0022-2623
PubMed: 38170624
DOI: 10.1021/ACS.JMEDCHEM.3C01933
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