Chlorine in PDB 8xpu: Overall Structure of the LAT1-4F2HC Bound with JPH203

The binding sites of Chlorine atom in the Overall Structure of the LAT1-4F2HC Bound with JPH203 (pdb code 8xpu). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Overall Structure of the LAT1-4F2HC Bound with JPH203, PDB code: 8xpu:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Overall Structure of the LAT1-4F2HC Bound with JPH203


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Overall Structure of the LAT1-4F2HC Bound with JPH203 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl601 b:221.1 occ:1.00 CL1 B:VRW601 0.0 221.1 1.0 C20 B:VRW601 1.8 220.3 1.0 C15 B:VRW601 2.9 220.4 1.0 C19 B:VRW601 2.9 220.1 1.0 O2 B:VRW601 3.1 220.7 1.0 O B:TYR254 3.7 49.0 1.0 ND2 B:ASN404 3.8 46.4 1.0 CA B:GLY255 4.1 37.1 1.0 C14 B:VRW601 4.3 220.5 1.0 O B:LEU251 4.3 50.1 1.0 C16 B:VRW601 4.3 220.5 1.0 C18 B:VRW601 4.3 220.1 1.0 C12 B:VRW601 4.4 220.6 1.0 C13 B:VRW601 4.5 220.6 1.0 O1 B:VRW601 4.6 220.6 1.0 C B:TYR254 4.6 43.3 1.0 CA B:PHE252 4.7 53.6 1.0 O B:PHE252 4.7 59.1 1.0 CD1 B:PHE252 4.7 59.0 1.0 N B:GLY255 4.8 36.0 1.0 C17 B:VRW601 4.8 220.2 1.0

Chlorine binding site 2 out of 2 in the Overall Structure of the LAT1-4F2HC Bound with JPH203


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Overall Structure of the LAT1-4F2HC Bound with JPH203 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl601 b:221.4 occ:1.00 CL2 B:VRW601 0.0 221.4 1.0 C16 B:VRW601 1.8 220.5 1.0 OH B:TYR259 2.7 39.0 1.0 C17 B:VRW601 2.9 220.2 1.0 C15 B:VRW601 2.9 220.4 1.0 C14 B:VRW601 2.9 220.5 1.0 O2 B:VRW601 3.2 220.7 1.0 CZ B:TYR259 3.2 38.7 1.0 CE2 B:TYR259 3.3 40.7 1.0 O1 B:VRW601 3.9 220.6 1.0 C12 B:VRW601 4.0 220.6 1.0 C13 B:VRW601 4.3 220.6 1.0 C20 B:VRW601 4.3 220.3 1.0 C18 B:VRW601 4.3 220.1 1.0 O B:GLY255 4.3 41.0 1.0 CE1 B:TYR259 4.3 33.6 1.0 CD2 B:TYR259 4.4 38.6 1.0 CG2 B:THR62 4.5 32.2 1.0 C B:GLY255 4.6 35.2 1.0 C19 B:VRW601 4.8 220.1 1.0 N B:GLY256 4.9 35.5 1.0

Z.Hu, R.Yan. Structural Basis For the Inhibition Mechanism of LAT1-4F2HC Complex By JPH203. Cell Discov V. 10 73 2024.
ISSN: ESSN 2056-5968
PubMed: 38956038
DOI: 10.1038/S41421-024-00697-6