Chlorine in PDB 9bwt: Human Sodium Chloride Cotransporter Ncc S344E in the Phosphorylation State and in Complex with Hydrochlorothiazide

The binding sites of Chlorine atom in the Human Sodium Chloride Cotransporter Ncc S344E in the Phosphorylation State and in Complex with Hydrochlorothiazide (pdb code 9bwt). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Sodium Chloride Cotransporter Ncc S344E in the Phosphorylation State and in Complex with Hydrochlorothiazide, PDB code: 9bwt:

Chlorine binding site 1 out of 1 in the Human Sodium Chloride Cotransporter Ncc S344E in the Phosphorylation State and in Complex with Hydrochlorothiazide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Sodium Chloride Cotransporter Ncc S344E in the Phosphorylation State and in Complex with Hydrochlorothiazide within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1302 b:142.5 occ:1.00 CL11 A:HCZ1302 0.0 142.5 1.0 C10 A:HCZ1302 1.8 125.5 1.0 C05 A:HCZ1302 2.8 126.2 1.0 C09 A:HCZ1302 2.8 122.7 1.0 H09 A:HCZ1302 2.9 120.7 1.0 O03 A:HCZ1302 3.1 128.2 1.0 O04 A:HCZ1302 3.1 129.1 1.0 S02 A:HCZ1302 3.1 144.8 1.0 CB A:LEU354 3.2 77.3 1.0 CD1 A:LEU354 3.2 82.5 1.0 CG A:LEU354 3.3 83.3 1.0 CZ A:PHE222 3.5 88.7 1.0 N A:LEU354 3.8 84.8 1.0 CE2 A:PHE222 3.9 86.3 1.0 OH A:TYR539 3.9 95.8 1.0 CA A:LEU354 4.0 80.5 1.0 CE1 A:TYR539 4.0 82.3 1.0 C06 A:HCZ1302 4.1 124.0 1.0 C08 A:HCZ1302 4.1 125.6 1.0 CD1 A:PHE535 4.1 101.4 1.0 CE1 A:PHE535 4.2 100.9 1.0 CZ A:TYR539 4.5 85.8 1.0 C A:LEU354 4.5 83.3 1.0 CA A:GLY352 4.5 94.7 1.0 N A:ILE353 4.5 86.6 1.0 C07 A:HCZ1302 4.6 127.2 1.0 C A:GLY352 4.7 96.7 1.0 CE1 A:PHE222 4.7 87.4 1.0 CD2 A:LEU354 4.8 83.8 1.0 N01 A:HCZ1302 4.8 128.1 1.0 N A:ALA355 4.9 88.0 1.0 OD1 A:ASN148 4.9 106.6 1.0 H06 A:HCZ1302 4.9 122.0 1.0 C A:ILE353 5.0 84.4 1.0 O A:THR351 5.0 105.1 1.0

Y.Zhao, H.Schubert, A.Blakely, B.Forbush, M.D.Smith, J.Rinehart, E.Cao. Structural Bases For Na + -Cl - Cotransporter Inhibition By Thiazide Diuretic Drugs and Activation By Kinases. Nat Commun V. 15 7006 2024.
ISSN: ESSN 2041-1723
PubMed: 39143061
DOI: 10.1038/S41467-024-51381-Y