Chlorine in PDB 9csl: Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D-C247L) in Complex with Isopentenyl Pyrophosphate

Enzymatic activity of Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D-C247L) in Complex with Isopentenyl Pyrophosphate

All present enzymatic activity of Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D-C247L) in Complex with Isopentenyl Pyrophosphate:
2.5.1.1; 2.5.1.10; 2.5.1.29;

Protein crystallography data

The structure of Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D-C247L) in Complex with Isopentenyl Pyrophosphate, PDB code: 9csl was solved by S.Ezekiel, J.Park, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 95.56 / 2.10
Space group P 6 2 2
Cell size a, b, c (Å), α, β, γ (°) 191.11, 191.11, 96.63, 90, 90, 120
R / Rfree (%) 17.9 / 21.6

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D-C247L) in Complex with Isopentenyl Pyrophosphate (pdb code 9csl). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D-C247L) in Complex with Isopentenyl Pyrophosphate, PDB code: 9csl:

Chlorine binding site 1 out of 1 in 9csl

Go back to Chlorine Binding Sites List in 9csl
Chlorine binding site 1 out of 1 in the Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D-C247L) in Complex with Isopentenyl Pyrophosphate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D-C247L) in Complex with Isopentenyl Pyrophosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl402

b:81.5
occ:1.00
 O A:HOH682 3.0 72.9 1.0
O A:HOH514 3.1 58.2 1.0
ND1 A:HIS37 3.1 53.9 1.0
O A:HOH683 3.9 67.7 1.0
O A:HOH600 3.9 62.9 1.0
CE1 A:HIS37 4.1 51.3 1.0
CG A:HIS37 4.1 54.5 1.0
CA A:HIS37 4.1 40.5 1.0
CB A:HIS37 4.2 42.3 1.0
O A:HOH624 4.7 50.1 1.0
NZ A:LYS40 4.8 73.1 1.0
O A:HIS37 4.9 41.2 1.0

Reference:

S.J.Ezekiel, M.Searle, J.Park. Engineering Dimer Mutants of Human Geranylgeranyl Pyrophosphate Synthase. Plos One V. 20 17437 2025.
ISSN: ESSN 1932-6203
PubMed: 39813274
DOI: 10.1371/JOURNAL.PONE.0317437
Page generated: Sun Feb 9 06:46:37 2025

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