Chlorine in PDB 9egv: Hoil-1 RING2 Domain Bound to Ubiquitin

All present enzymatic activity of Hoil-1 RING2 Domain Bound to Ubiquitin:
2.3.2.31;

The structure of Hoil-1 RING2 Domain Bound to Ubiquitin, PDB code: 9egv was solved by X.S.Wang, B.C.Lechtenberg, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.96 / 2.00
Space group	I 41 2 2
Cell size a, b, c (Å), α, β, γ (°)	95.922, 95.922, 187.429, 90, 90, 90
R / Rfree (%)	18 / 20.8

The structure of Hoil-1 RING2 Domain Bound to Ubiquitin also contains other interesting chemical elements:

Zinc

(Zn)

6 atoms

The binding sites of Chlorine atom in the Hoil-1 RING2 Domain Bound to Ubiquitin (pdb code 9egv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Hoil-1 RING2 Domain Bound to Ubiquitin, PDB code: 9egv:

Chlorine binding site 1 out of 1 in the Hoil-1 RING2 Domain Bound to Ubiquitin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Hoil-1 RING2 Domain Bound to Ubiquitin within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl604 b:33.9 occ:1.00 H A:GLU471 2.4 32.9 1.0 HD1 A:TRP481 2.8 32.6 1.0 HD3 A:PRO486 3.0 39.4 1.0 O A:HOH707 3.0 39.6 1.0 HB2 A:GLU471 3.1 36.5 1.0 O A:HOH717 3.2 24.4 1.0 HA A:THR470 3.2 36.0 1.0 N A:GLU471 3.3 27.4 1.0 HA2 A:GLY485 3.3 39.8 1.0 HG3 A:GLU471 3.3 42.6 1.0 HG23 A:THR470 3.4 35.1 1.0 O A:HOH716 3.5 45.0 1.0 HB2 A:TRP481 3.6 30.5 1.0 HG3 A:PRO486 3.6 44.8 1.0 CD1 A:TRP481 3.7 27.1 1.0 CD A:PRO486 3.8 32.9 1.0 CB A:GLU471 3.8 30.4 1.0 CG A:GLU471 4.0 35.5 1.0 CA A:THR470 4.0 30.0 1.0 CA A:GLU471 4.1 30.1 1.0 CA A:GLY485 4.1 33.1 1.0 C A:THR470 4.1 31.2 1.0 N A:PRO486 4.2 30.5 1.0 CG A:PRO486 4.2 37.3 1.0 CG2 A:THR470 4.3 29.3 1.0 C A:GLY485 4.4 31.8 1.0 CB A:TRP481 4.4 25.4 1.0 CG A:TRP481 4.4 26.0 1.0 HA3 A:GLY485 4.4 39.8 1.0 O A:GLU471 4.5 25.3 1.0 O A:HIS469 4.6 33.6 1.0 HD2 A:PRO486 4.6 39.4 1.0 HG22 A:THR470 4.6 35.1 1.0 CD A:GLU471 4.6 39.8 1.0 HB3 A:GLU471 4.7 36.5 1.0 HA A:PRO486 4.7 37.9 1.0 NE1 A:TRP481 4.7 26.9 1.0 CB A:THR470 4.7 29.9 1.0 H A:TRP481 4.8 28.8 1.0 HG2 A:PRO486 4.8 44.8 1.0 HG2 A:GLU471 4.8 42.6 1.0 C A:GLU471 4.8 27.4 1.0 HE1 A:TRP481 4.8 32.3 1.0 HB3 A:ARG480 4.8 28.9 1.0 HA A:GLU471 4.8 36.1 1.0 O A:HOH725 4.9 42.6 1.0 CA A:PRO486 4.9 31.6 1.0 HB3 A:TRP481 5.0 30.5 1.0 HG21 A:THR470 5.0 35.1 1.0

X.S.Wang, J.Jiou, A.Cerra, S.A.Cobbold, M.Jochem, K.H.T.Mak, L.Corcilius, R.J.Payne, E.D.Goddard-Borger, D.Komander, B.C.Lechtenberg. The Rbr E3 Ubiquitin Ligase Hoil-1 Can Ubiquitinate Diverse Non-Protein Substrates in Vitro Biorxiv 2024.
ISSN: ISSN 2692-8205