Chlorine in PDB 9myl: Fertilization IZUMO1 Protein Ectodomain in Complex with Anti-Sperm Antibody OBF13

The structure of Fertilization IZUMO1 Protein Ectodomain in Complex with Anti-Sperm Antibody OBF13, PDB code: 9myl was solved by S.Tang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.06 / 3.18
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	81.069, 83.208, 92.605, 82.85, 89.72, 71.4
R / Rfree (%)	21.2 / 26.3

The binding sites of Chlorine atom in the Fertilization IZUMO1 Protein Ectodomain in Complex with Anti-Sperm Antibody OBF13 (pdb code 9myl). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Fertilization IZUMO1 Protein Ectodomain in Complex with Anti-Sperm Antibody OBF13, PDB code: 9myl:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Fertilization IZUMO1 Protein Ectodomain in Complex with Anti-Sperm Antibody OBF13


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Fertilization IZUMO1 Protein Ectodomain in Complex with Anti-Sperm Antibody OBF13 within 5.0Å range: probe atom residue distance (Å) B Occ L:Cl301 b:90.5 occ:1.00 O L:GLY41 3.0 81.5 1.0 O H:GLN107 3.6 87.2 1.0 CG1 H:VAL93 3.9 52.6 1.0 OH H:TYR95 3.9 72.7 1.0 C L:GLY41 4.0 79.8 1.0 CE1 H:TYR95 4.6 68.5 1.0 CG2 H:VAL93 4.6 77.0 1.0 CZ H:TYR95 4.7 61.7 1.0 CA L:GLY41 4.7 66.0 1.0 CA H:GLY108 4.8 81.6 1.0 C H:GLN107 4.8 71.0 1.0 CB H:VAL93 4.9 56.2 1.0 N L:GLN42 4.9 77.9 1.0 O H:GLY108 5.0 86.2 1.0 C H:GLY108 5.0 86.1 1.0

Chlorine binding site 2 out of 2 in the Fertilization IZUMO1 Protein Ectodomain in Complex with Anti-Sperm Antibody OBF13


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Fertilization IZUMO1 Protein Ectodomain in Complex with Anti-Sperm Antibody OBF13 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:84.0 occ:1.00 O A:GLN107 3.5 91.5 1.0 O B:GLY41 3.6 89.5 1.0 OH A:TYR95 3.6 68.1 1.0 CG1 A:VAL93 3.9 61.8 1.0 C B:GLY41 4.1 73.3 1.0 CZ A:TYR95 4.4 77.1 1.0 CE1 A:TYR95 4.4 78.7 1.0 CG2 A:THR110 4.6 98.0 1.0 C A:GLN107 4.7 81.3 1.0 CA B:GLY41 4.7 72.0 1.0 CG2 A:VAL93 4.8 67.5 1.0 N B:GLN42 4.8 67.2 1.0 CA A:GLY108 4.8 70.4 1.0 O A:GLY108 4.9 84.9 1.0 CB A:VAL93 5.0 58.8 1.0 C A:GLY108 5.0 76.1 1.0

Y.Lu, M.Ikawa, S.Tang. Allosteric Inhibition of the IZUMO1-Juno Fertilization Complex By the Naturally Occurring Antisperm Antibody OBF13. Proc.Natl.Acad.Sci.Usa V. 122 52122 2025.
ISSN: ESSN 1091-6490
PubMed: 40042902
DOI: 10.1073/PNAS.2425952122