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Chlorine in PDB 9nov: Human Sweet Taste Receptor (TAS1R2 + TAS1R3) Vft Domains Bound to Sucralose

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human Sweet Taste Receptor (TAS1R2 + TAS1R3) Vft Domains Bound to Sucralose (pdb code 9nov). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Human Sweet Taste Receptor (TAS1R2 + TAS1R3) Vft Domains Bound to Sucralose, PDB code: 9nov:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 9nov

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Chlorine binding site 1 out of 3 in the Human Sweet Taste Receptor (TAS1R2 + TAS1R3) Vft Domains Bound to Sucralose


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Sweet Taste Receptor (TAS1R2 + TAS1R3) Vft Domains Bound to Sucralose within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1

b:117.5
occ:1.00
CL6 C:RRY1 0.0 117.5 1.0
C6 C:RRY1 1.8 106.2 1.0
C5 C:RRY1 2.7 106.5 1.0
C4 C:RRY1 3.0 110.1 1.0
O4 C:RRY1 3.1 110.5 1.0
NZ A:LYS65 3.5 97.4 1.0
CB A:TYR103 3.5 99.8 1.0
CD A:LYS65 3.9 93.4 1.0
O5 C:RRY1 4.0 103.2 1.0
CG A:TYR103 4.1 102.0 1.0
CB A:ALA43 4.2 105.5 1.0
CE A:LYS65 4.3 95.2 1.0
CB A:SER40 4.3 89.0 1.0
CD1 A:TYR103 4.3 101.5 1.0
OG A:SER40 4.4 93.2 1.0
O6 C:RRJ2 4.4 101.0 1.0
C3 C:RRY1 4.4 107.3 1.0
CA A:TYR103 4.5 96.6 1.0
CD1 A:LEU279 4.7 96.9 1.0
C2 C:RRY1 4.9 106.3 1.0
O A:HIS42 4.9 94.8 1.0

Chlorine binding site 2 out of 3 in 9nov

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Chlorine binding site 2 out of 3 in the Human Sweet Taste Receptor (TAS1R2 + TAS1R3) Vft Domains Bound to Sucralose


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Sweet Taste Receptor (TAS1R2 + TAS1R3) Vft Domains Bound to Sucralose within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1

b:109.4
occ:1.00
CL1 C:RRY1 0.0 109.4 1.0
C1 C:RRY1 1.8 105.1 1.0
C2 C:RRY1 2.7 106.3 1.0
C3 C:RRY1 2.8 107.3 1.0
O5 C:RRY1 3.2 103.2 1.0
CB A:ASN143 3.6 90.9 1.0
C5 C:RRY1 3.6 106.5 1.0
C4 C:RRY1 3.6 110.1 1.0
O4 C:RRY1 3.8 110.5 1.0
O2 C:RRY1 3.9 103.5 1.0
O3 C:RRY1 4.0 99.5 1.0
CE1 A:TYR103 4.2 101.2 1.0
CA A:ASN143 4.5 87.4 1.0
CD1 A:TYR103 4.6 101.5 1.0
CG A:PRO277 4.7 82.3 1.0
CG A:ASN143 4.7 93.3 1.0
CB A:PRO277 4.8 81.8 1.0
CD2 A:TYR215 4.8 86.2 1.0
C1 C:RRJ2 4.9 102.1 1.0
CG A:TYR215 5.0 89.7 1.0

Chlorine binding site 3 out of 3 in 9nov

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Chlorine binding site 3 out of 3 in the Human Sweet Taste Receptor (TAS1R2 + TAS1R3) Vft Domains Bound to Sucralose


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Human Sweet Taste Receptor (TAS1R2 + TAS1R3) Vft Domains Bound to Sucralose within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl2

b:114.9
occ:1.00
CL4 C:RRJ2 0.0 114.9 1.0
C4 C:RRJ2 1.8 102.2 1.0
C6 C:RRJ2 2.7 101.8 1.0
C3 C:RRJ2 2.7 97.1 1.0
C5 C:RRJ2 2.7 103.3 1.0
O3 C:RRJ2 2.9 91.7 1.0
OG A:SER165 3.0 89.1 1.0
C2 C:RRJ2 3.1 97.7 1.0
CB A:SER165 3.5 85.1 1.0
O5 C:RRJ2 3.7 105.0 1.0
CD1 A:LEU71 3.8 64.5 1.0
C1 C:RRJ2 3.8 102.1 1.0
CG1 A:VAL384 3.9 70.7 1.0
O6 C:RRJ2 4.1 101.0 1.0
CB A:ASP142 4.3 87.7 1.0
O2 C:RRJ2 4.3 94.1 1.0
CG2 A:VAL384 4.4 61.5 1.0
CB A:VAL384 4.5 65.3 1.0
CG2 A:ILE67 4.6 77.3 1.0
CD1 A:TYR164 4.6 72.3 1.0
CE1 A:TYR164 4.7 71.4 1.0
O A:ASP142 4.9 91.7 1.0
CA A:SER165 5.0 80.1 1.0

Reference:

Z.Juen, Z.Lu, R.Yu, A.N.Chang, B.Wang, A.W.Fitzpatrick, C.S.Zuker. The Structure of Human Sweetness Cell(Cambridge,Mass.) 2025.
ISSN: ISSN 0092-8674
DOI: 10.1016/J.CELL.2025.04.021
Page generated: Sun Jul 13 17:17:25 2025

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