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Chlorine in PDB 1c8l: Synergistic Inhibition of Glycogen Phosphorylase A By A Potential Antidiabetic Drug and Caffeine

Enzymatic activity of Synergistic Inhibition of Glycogen Phosphorylase A By A Potential Antidiabetic Drug and Caffeine

All present enzymatic activity of Synergistic Inhibition of Glycogen Phosphorylase A By A Potential Antidiabetic Drug and Caffeine:
2.4.1.1;

Protein crystallography data

The structure of Synergistic Inhibition of Glycogen Phosphorylase A By A Potential Antidiabetic Drug and Caffeine, PDB code: 1c8l was solved by K.E.Tsitsanou, V.T.Skamnaki, N.G.Oikonomakos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 26.50 / 2.30
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 126.690, 126.690, 115.300, 90.00, 90.00, 90.00
R / Rfree (%) 21 / 25.7

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Synergistic Inhibition of Glycogen Phosphorylase A By A Potential Antidiabetic Drug and Caffeine (pdb code 1c8l). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Synergistic Inhibition of Glycogen Phosphorylase A By A Potential Antidiabetic Drug and Caffeine, PDB code: 1c8l:

Chlorine binding site 1 out of 1 in 1c8l

Go back to Chlorine Binding Sites List in 1c8l
Chlorine binding site 1 out of 1 in the Synergistic Inhibition of Glycogen Phosphorylase A By A Potential Antidiabetic Drug and Caffeine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Synergistic Inhibition of Glycogen Phosphorylase A By A Potential Antidiabetic Drug and Caffeine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl930

b:31.7
occ:1.00
 CL2 A:BIN930 0.0 31.7 1.0
C2 A:BIN930 1.7 27.4 1.0
C3 A:BIN930 2.7 27.6 1.0
C1 A:BIN930 2.8 26.7 1.0
NH1 A:ARG193 2.9 38.5 1.0
C7 A:BIN930 3.3 24.2 1.0
O A:HOH1396 3.3 31.3 1.0
O3A A:BIN930 3.4 23.5 1.0
O8 A:BIN930 3.5 22.4 1.0
CD A:ARG193 3.7 31.2 1.0
OD2 A:ASP227 3.8 15.5 1.0
CZ A:ARG193 3.8 35.8 1.0
NH2 A:ARG242 3.8 26.9 1.0
C20 A:BIN930 4.0 27.4 1.0
C4 A:BIN930 4.1 26.3 1.0
NE A:ARG193 4.1 34.7 1.0
C21 A:BIN930 4.1 19.9 1.0
C13 A:BIN930 4.1 21.3 1.0
C6 A:BIN930 4.2 24.9 1.0
C19 A:BIN930 4.2 23.8 1.0
O A:HOH1345 4.2 31.3 1.0
C12 A:BIN930 4.3 23.1 1.0
C18 A:BIN930 4.4 21.4 1.0
C8 A:BIN930 4.4 20.9 1.0
C5 A:BIN930 4.6 27.5 1.0
CE2 A:PHE196 4.8 25.6 1.0
NH2 A:ARG193 4.8 36.2 1.0
CG A:ASP227 5.0 18.8 1.0

Reference:

K.E.Tsitsanou, V.T.Skamnaki, N.G.Oikonomakos. Structural Basis of the Synergistic Inhibition of Glycogen Phosphorylase A By Caffeine and A Potential Antidiabetic Drug. Arch.Biochem.Biophys. V. 384 245 2000.
ISSN: ISSN 0003-9861
PubMed: 11368311
DOI: 10.1006/ABBI.2000.2121
Page generated: Sat Dec 12 08:32:49 2020

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