Chlorine in PDB 1cet: Chloroquine Binds in the Cofactor Binding Site of Plasmodium Falciparum Lactate Dehydrogenase.

Enzymatic activity of Chloroquine Binds in the Cofactor Binding Site of Plasmodium Falciparum Lactate Dehydrogenase.

All present enzymatic activity of Chloroquine Binds in the Cofactor Binding Site of Plasmodium Falciparum Lactate Dehydrogenase.:
1.1.1.27;

Protein crystallography data

The structure of Chloroquine Binds in the Cofactor Binding Site of Plasmodium Falciparum Lactate Dehydrogenase., PDB code: 1cet was solved by J.A.Read, K.W.Wilkinson, R.Tranter, R.B.Sessions, R.L.Brady, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	20.00 / 2.05
*Space group*	I 2 2 2
*Cell size a, b, c (Å), α, β, γ (°)*	79.930, 85.440, 92.190, 90.00, 90.00, 90.00
*R / R_free (%)*	15.4 / 19.3

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Chloroquine Binds in the Cofactor Binding Site of Plasmodium Falciparum Lactate Dehydrogenase. (pdb code 1cet). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Chloroquine Binds in the Cofactor Binding Site of Plasmodium Falciparum Lactate Dehydrogenase., PDB code: 1cet:

Chlorine binding site 1 out of 1 in 1cet

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Chlorine Binding Sites List in 1cet

Chlorine binding site 1 out of 1 in the Chloroquine Binds in the Cofactor Binding Site of Plasmodium Falciparum Lactate Dehydrogenase.

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Chloroquine Binds in the Cofactor Binding Site of Plasmodium Falciparum Lactate Dehydrogenase. within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl1001 b:22.7 occ:1.00	CL	A:CLQ1001	0.0	22.7	1.0
	C7	A:CLQ1001	1.7	31.9	1.0
	C8	A:CLQ1001	2.7	32.4	1.0
	C6	A:CLQ1001	2.7	32.9	1.0
	CB	A:ALA98	3.5	11.5	1.0
	N	A:GLY27	3.5	10.7	1.0
	CA	A:GLY27	3.6	9.8	1.0
	CE1	A:PHE52	3.7	9.8	1.0
	CA	A:ASP53	3.7	11.0	1.0
	CD1	A:PHE52	3.7	10.2	1.0
	C	A:VAL26	3.8	9.8	1.0
	CG1	A:VAL26	3.8	9.2	1.0
	O	A:PHE52	3.9	9.3	1.0
	CG	A:ASP53	3.9	11.8	1.0
	OD1	A:ASP53	4.0	10.7	1.0
	C5	A:CLQ1001	4.0	34.9	1.0
	C9	A:CLQ1001	4.0	35.4	1.0
	OD2	A:ASP53	4.1	11.6	1.0
	O	A:VAL26	4.2	10.5	1.0
	CB	A:ASP53	4.4	10.8	1.0
	N	A:ASP53	4.4	7.8	1.0
	N	A:ILE54	4.4	13.1	1.0
	C	A:PHE52	4.4	8.0	1.0
	CA	A:VAL26	4.5	8.7	1.0
	C	A:ASP53	4.5	12.1	1.0
	C4	A:CLQ1001	4.6	33.7	1.0
	CA	A:ALA98	4.6	11.7	1.0
	O	A:HOH1146	4.6	21.0	1.0
	CG2	A:ILE54	4.7	18.4	1.0
	CB	A:VAL26	4.8	7.3	1.0
	C	A:GLY27	4.9	9.6	1.0
	CZ	A:PHE52	4.9	10.4	1.0

Reference:

J.A.Read, K.W.Wilkinson, R.Tranter, R.B.Sessions, R.L.Brady. Chloroquine Binds in the Cofactor Binding Site of Plasmodium Falciparum Lactate Dehydrogenase. J.Biol.Chem. V. 274 10213 1999.
ISSN: ISSN 0021-9258
PubMed: 10187806
DOI: 10.1074/JBC.274.15.10213

Page generated: Thu Jul 10 16:30:50 2025

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