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Chlorine in PDB 1cjv: Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp, Mg, and Zn

Enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp, Mg, and Zn

All present enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp, Mg, and Zn:
4.6.1.1;

Protein crystallography data

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp, Mg, and Zn, PDB code: 1cjv was solved by J.J.G.Tesmer, S.R.Sprang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 3.00
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 118.400, 134.200, 71.600, 90.00, 90.00, 90.00
R / Rfree (%) 20.3 / 26.2

Other elements in 1cjv:

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp, Mg, and Zn also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms
Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp, Mg, and Zn (pdb code 1cjv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp, Mg, and Zn, PDB code: 1cjv:

Chlorine binding site 1 out of 1 in 1cjv

Go back to Chlorine Binding Sites List in 1cjv
Chlorine binding site 1 out of 1 in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp, Mg, and Zn


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp, Mg, and Zn within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl404

b:35.2
occ:1.00
O C:HOH408 3.2 12.2 1.0
N C:ALA249 3.2 16.0 1.0
O C:HOH411 3.3 38.9 1.0
O C:HOH415 3.3 4.3 1.0
CB C:SER51 3.6 15.8 1.0
O C:HOH410 3.6 12.3 1.0
CB C:ALA249 3.6 19.6 1.0
CB C:ALA48 3.9 15.2 1.0
CA C:ALA249 4.0 17.0 1.0
CB C:ALA269 4.1 22.1 1.0
CA C:VAL248 4.1 13.6 1.0
C C:VAL248 4.2 16.1 1.0
CA C:SER51 4.2 13.8 1.0
CG1 C:VAL248 4.4 10.4 1.0
O C:ARG265 4.5 21.8 1.0
N C:ALA48 4.6 15.1 1.0
CA C:ALA48 4.7 16.0 1.0
OG C:SER51 4.7 17.5 1.0
O C:ALA48 4.7 16.9 1.0
O C:ALA249 4.7 16.6 1.0
C C:ALA249 4.8 16.7 1.0
N C:SER51 4.8 14.2 1.0
C C:ALA48 4.8 16.4 1.0
O C:VAL247 4.8 12.6 1.0
CB C:VAL248 4.8 12.2 1.0
O C:GLY49 4.9 13.4 1.0

Reference:

J.J.Tesmer, R.K.Sunahara, R.A.Johnson, G.Gosselin, A.G.Gilman, S.R.Sprang. Two-Metal-Ion Catalysis in Adenylyl Cyclase. Science V. 285 756 1999.
ISSN: ISSN 0036-8075
PubMed: 10427002
DOI: 10.1126/SCIENCE.285.5428.756
Page generated: Sat Dec 12 08:33:02 2020

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