Chlorine in PDB 1cs4: Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'-Deoxy-Adenosine 3'- Monophosphate, Pyrophosphate and Mg

Enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'-Deoxy-Adenosine 3'- Monophosphate, Pyrophosphate and Mg

All present enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'-Deoxy-Adenosine 3'- Monophosphate, Pyrophosphate and Mg:
4.6.1.1;

Protein crystallography data

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'-Deoxy-Adenosine 3'- Monophosphate, Pyrophosphate and Mg, PDB code: 1cs4 was solved by J.J.G.Tesmer, C.A.Dessauer, R.K.Sunahara, R.A.Johnson, A.G.Gilman, S.R.Sprang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	15.00 / 2.50
*Space group*	P 2₁ 2₁ 2
*Cell size a, b, c (Å), α, β, γ (°)*	118.500, 134.500, 71.300, 90.00, 90.00, 90.00
*R / R_free (%)*	21.6 / 26.4

Other elements in 1cs4:

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'-Deoxy-Adenosine 3'- Monophosphate, Pyrophosphate and Mg also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'-Deoxy-Adenosine 3'- Monophosphate, Pyrophosphate and Mg (pdb code 1cs4). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'-Deoxy-Adenosine 3'- Monophosphate, Pyrophosphate and Mg, PDB code: 1cs4:

Chlorine binding site 1 out of 1 in 1cs4

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Chlorine Binding Sites List in 1cs4

Chlorine binding site 1 out of 1 in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'-Deoxy-Adenosine 3'- Monophosphate, Pyrophosphate and Mg

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'-Deoxy-Adenosine 3'- Monophosphate, Pyrophosphate and Mg within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
C:Cl398 b:39.1 occ:1.00	O	C:HOH1002	3.2	30.6	1.0
	N	C:ALA249	3.3	32.5	1.0
	O	C:HOH1005	3.3	30.9	1.0
	O	C:HOH1011	3.3	36.3	1.0
	O	C:HOH1006	3.4	35.0	1.0
	CB	C:ALA249	3.6	29.6	1.0
	CB	C:SER51	3.8	28.5	1.0
	CB	C:ALA48	3.9	34.4	1.0
	CB	C:ALA269	4.0	32.9	1.0
	CA	C:ALA249	4.0	30.4	1.0
	CA	C:VAL248	4.2	27.2	1.0
	C	C:VAL248	4.2	30.1	1.0
	CA	C:SER51	4.3	27.6	1.0
	CG1	C:VAL248	4.4	22.6	1.0
	O	C:ARG265	4.6	35.7	1.0
	N	C:ALA48	4.7	29.0	1.0
	CA	C:ALA48	4.7	33.8	1.0
	O	C:VAL247	4.8	28.9	1.0
	C	C:ALA249	4.8	31.4	1.0
	O	C:ALA249	4.8	31.5	1.0
	O	C:GLY49	4.9	32.6	1.0
	N	C:SER51	4.9	28.1	1.0
	CB	C:VAL248	4.9	26.6	1.0
	OG	C:SER51	4.9	33.4	1.0
	C	C:ALA48	4.9	36.3	1.0
	O	C:HOH1003	5.0	24.5	1.0

Reference:

J.J.Tesmer, C.W.Dessauer, R.K.Sunahara, L.D.Murray, R.A.Johnson, A.G.Gilman, S.R.Sprang. Molecular Basis For P-Site Inhibition of Adenylyl Cyclase. Biochemistry V. 39 14464 2000.
ISSN: ISSN 0006-2960
PubMed: 11087399
DOI: 10.1021/BI0015562

Page generated: Sat Dec 12 08:33:11 2020

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