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Chlorine in PDB 1cul: Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2',5'-Dideoxy-Adenosine 3'- Triphosphate and Mg

Enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2',5'-Dideoxy-Adenosine 3'- Triphosphate and Mg

All present enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2',5'-Dideoxy-Adenosine 3'- Triphosphate and Mg:
4.6.1.1;

Protein crystallography data

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2',5'-Dideoxy-Adenosine 3'- Triphosphate and Mg, PDB code: 1cul was solved by J.J.G.Tesmer, C.A.Dessauer, R.K.Sunahara, R.A.Johnson, A.G.Gilman, S.R.Sprang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 2.40
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 118.200, 133.600, 70.600, 90.00, 90.00, 90.00
R / Rfree (%) 21.6 / 26.3

Other elements in 1cul:

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2',5'-Dideoxy-Adenosine 3'- Triphosphate and Mg also contains other interesting chemical elements:

Magnesium (Mg) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2',5'-Dideoxy-Adenosine 3'- Triphosphate and Mg (pdb code 1cul). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2',5'-Dideoxy-Adenosine 3'- Triphosphate and Mg, PDB code: 1cul:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 1cul

Go back to Chlorine Binding Sites List in 1cul
Chlorine binding site 1 out of 2 in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2',5'-Dideoxy-Adenosine 3'- Triphosphate and Mg


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2',5'-Dideoxy-Adenosine 3'- Triphosphate and Mg within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl397

b:34.0
occ:1.00
 O C:HOH433 3.2 50.1 1.0
N C:ALA249 3.2 31.7 1.0
O C:HOH410 3.2 23.5 1.0
O C:HOH400 3.3 32.1 1.0
O C:HOH403 3.4 29.8 1.0
CB C:SER51 3.5 25.4 1.0
CB C:ALA249 3.6 31.7 1.0
CB C:ALA48 3.8 28.3 1.0
CB C:ALA269 4.0 21.3 1.0
CA C:ALA249 4.0 33.1 1.0
CA C:VAL248 4.0 26.9 1.0
C C:VAL248 4.1 30.6 1.0
CA C:SER51 4.2 24.0 1.0
CG1 C:VAL248 4.3 22.2 1.0
OG C:SER51 4.6 24.3 1.0
O C:ARG265 4.6 30.2 1.0
O C:VAL247 4.6 31.7 1.0
N C:ALA48 4.6 28.1 1.0
CA C:ALA48 4.7 31.0 1.0
N C:SER51 4.8 22.9 1.0
O C:ALA48 4.8 33.4 1.0
CB C:VAL248 4.8 26.7 1.0
C C:ALA249 4.8 33.8 1.0
C C:ALA48 4.8 32.1 1.0
O C:ALA249 4.9 35.3 1.0
O C:GLY49 4.9 27.1 1.0
CA C:ALA269 5.0 25.3 1.0

Chlorine binding site 2 out of 2 in 1cul

Go back to Chlorine Binding Sites List in 1cul
Chlorine binding site 2 out of 2 in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2',5'-Dideoxy-Adenosine 3'- Triphosphate and Mg


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2',5'-Dideoxy-Adenosine 3'- Triphosphate and Mg within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl398

b:40.8
occ:0.50
 NH2 C:ARG373 3.5 52.0 1.0
NE C:ARG373 3.6 50.2 1.0
CA C:GLU370 3.8 50.9 1.0
N C:GLU370 3.9 50.3 1.0
CZ C:ARG373 4.0 52.6 1.0
C C:THR369 4.1 48.3 1.0
O C:THR369 4.1 50.9 1.0
CG2 C:THR369 4.2 51.1 1.0
CB C:GLU370 4.4 52.6 1.0
CB C:THR369 4.5 48.1 1.0
CD C:ARG373 4.7 46.9 1.0
CD2 C:LEU63 4.9 46.3 1.0
CB C:ARG373 5.0 45.9 1.0
CA C:THR369 5.0 48.0 1.0

Reference:

J.J.Tesmer, C.W.Dessauer, R.K.Sunahara, L.D.Murray, R.A.Johnson, A.G.Gilman, S.R.Sprang. Molecular Basis For P-Site Inhibition of Adenylyl Cyclase. Biochemistry V. 39 14464 2000.
ISSN: ISSN 0006-2960
PubMed: 11087399
DOI: 10.1021/BI0015562
Page generated: Fri Jul 19 21:28:05 2024

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