Atomistry » Chlorine » PDB 1dhj-1e2y » 1dyh
Atomistry »
  Chlorine »
    PDB 1dhj-1e2y »
      1dyh »

Chlorine in PDB 1dyh: Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-Dideazatetrahydrofolate: Mechanistic Implications

Enzymatic activity of Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-Dideazatetrahydrofolate: Mechanistic Implications

All present enzymatic activity of Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-Dideazatetrahydrofolate: Mechanistic Implications:
1.5.1.3;

Protein crystallography data

The structure of Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-Dideazatetrahydrofolate: Mechanistic Implications, PDB code: 1dyh was solved by V.M.Reyes, J.Kraut, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) N/A / 1.90
Space group P 61
Cell size a, b, c (Å), α, β, γ (°) 93.205, 93.205, 73.942, 90.00, 90.00, 120.00
R / Rfree (%) n/a / n/a

Other elements in 1dyh:

The structure of Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-Dideazatetrahydrofolate: Mechanistic Implications also contains other interesting chemical elements:

Calcium (Ca) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-Dideazatetrahydrofolate: Mechanistic Implications (pdb code 1dyh). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-Dideazatetrahydrofolate: Mechanistic Implications, PDB code: 1dyh:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 1dyh

Go back to Chlorine Binding Sites List in 1dyh
Chlorine binding site 1 out of 2 in the Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-Dideazatetrahydrofolate: Mechanistic Implications


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-Dideazatetrahydrofolate: Mechanistic Implications within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl401

b:22.9
occ:1.00
 O A:HOH468 3.0 31.4 1.0
N A:GLY96 3.1 12.4 1.0
O A:HOH611 3.3 81.0 1.0
N A:THR46 3.4 16.1 1.0
N A:HIS45 3.4 16.5 1.0
CA A:GLY43 3.5 20.2 1.0
OG1 A:THR46 3.5 17.1 1.0
C A:GLY43 3.6 20.9 1.0
CB A:HIS45 3.6 15.0 1.0
CA A:GLY96 3.6 7.9 1.0
O A:HOH437 3.9 36.2 1.0
CA A:HIS45 3.9 11.4 1.0
N A:GLY43 3.9 18.4 1.0
N A:ARG44 3.9 18.5 1.0
O A:GLY43 4.0 18.8 1.0
C A:GLY95 4.1 17.6 1.0
C A:HIS45 4.1 16.2 1.0
O A:HOH429 4.2 44.6 1.0
O A:GLY95 4.2 19.7 1.0
CB A:THR46 4.2 14.7 1.0
ND1 A:HIS45 4.2 26.8 1.0
O A:HOH469 4.2 35.1 1.0
CA A:THR46 4.4 13.8 1.0
CG A:HIS45 4.4 17.4 1.0
C A:ARG44 4.4 22.7 1.0
C A:GLY96 4.6 11.2 1.0
CA A:ARG44 4.8 15.3 1.0

Chlorine binding site 2 out of 2 in 1dyh

Go back to Chlorine Binding Sites List in 1dyh
Chlorine binding site 2 out of 2 in the Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-Dideazatetrahydrofolate: Mechanistic Implications


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-Dideazatetrahydrofolate: Mechanistic Implications within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl405

b:23.9
occ:1.00
 O B:HOH544 3.1 30.3 1.0
N B:GLY96 3.2 19.5 1.0
N B:THR46 3.2 21.6 1.0
OG1 B:THR46 3.2 20.4 1.0
CA B:GLY43 3.5 16.7 1.0
C B:GLY43 3.6 19.4 1.0
N B:HIS45 3.6 23.8 1.0
CB B:THR46 3.7 22.9 1.0
CA B:GLY96 3.9 13.9 1.0
N B:GLY43 3.9 15.5 1.0
O B:GLY43 3.9 19.5 1.0
CB B:HIS45 3.9 29.6 1.0
CA B:HIS45 4.0 24.7 1.0
CA B:THR46 4.0 24.7 1.0
C B:HIS45 4.0 23.3 1.0
N B:ARG44 4.0 20.8 1.0
C B:GLY95 4.1 20.8 1.0
O B:GLY95 4.1 17.9 1.0
O B:HOH543 4.1 54.6 1.0
C B:ARG44 4.5 19.4 1.0
CD2 B:HIS45 4.7 50.3 1.0
CG B:HIS45 4.7 46.9 1.0
CG2 B:VAL99 4.7 15.3 1.0
C B:GLY96 4.8 15.9 1.0
O B:HOH433 4.9 34.7 1.0
CA B:ARG44 4.9 19.4 1.0
O B:HOH437 5.0 29.9 1.0

Reference:

V.M.Reyes, M.R.Sawaya, K.A.Brown, J.Kraut. Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5-Deazafolate, and 5,10-Dideazatetrahydrofolate: Mechanistic Implications. Biochemistry V. 34 2710 1995.
ISSN: ISSN 0006-2960
PubMed: 7873554
DOI: 10.1021/BI00008A039
Page generated: Fri Jul 19 21:42:23 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy