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Chlorine in PDB 1f5l: Urokinase Plasminogen Activator B-Chain-Amiloride Complex

Enzymatic activity of Urokinase Plasminogen Activator B-Chain-Amiloride Complex

All present enzymatic activity of Urokinase Plasminogen Activator B-Chain-Amiloride Complex:
3.4.21.73;

Protein crystallography data

The structure of Urokinase Plasminogen Activator B-Chain-Amiloride Complex, PDB code: 1f5l was solved by E.Zeslawska, A.Schweinitz, A.Karcher, P.Sondermann, S.Sperl, J.Sturzebecher, U.Jacob, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 500.00 / 2.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 52.800, 54.600, 82.920, 90.00, 90.00, 90.00
R / Rfree (%) 20.2 / 25

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Urokinase Plasminogen Activator B-Chain-Amiloride Complex (pdb code 1f5l). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Urokinase Plasminogen Activator B-Chain-Amiloride Complex, PDB code: 1f5l:

Chlorine binding site 1 out of 1 in 1f5l

Go back to Chlorine Binding Sites List in 1f5l
Chlorine binding site 1 out of 1 in the Urokinase Plasminogen Activator B-Chain-Amiloride Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Urokinase Plasminogen Activator B-Chain-Amiloride Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl301

b:37.4
occ:1.00
CL1 A:AMR301 0.0 37.4 1.0
C5 A:AMR301 1.7 40.6 1.0
N1 A:AMR301 2.7 32.6 1.0
C4 A:AMR301 2.8 43.6 1.0
N2 A:AMR301 3.1 44.8 1.0
C1 A:AMR301 3.9 28.1 1.0
N3 A:AMR301 4.0 39.0 1.0
SG A:CYS220 4.1 23.0 1.0
O A:GLY219 4.1 29.0 1.0
O A:GLY216 4.3 25.5 1.0
CA A:GLY219 4.4 24.8 1.0
C A:GLY219 4.4 28.6 1.0
N A:GLY219 4.4 21.1 1.0
CB A:GLN192 4.5 30.7 1.0
C2 A:AMR301 4.5 24.5 1.0
O A:HOH529 4.5 35.2 1.0
N A:GLN192 4.6 21.6 1.0
CA A:GLN192 4.8 27.4 1.0

Reference:

E.Zeslawska, A.Schweinitz, A.Karcher, P.Sondermann, S.Sperl, J.Sturzebecher, U.Jacob. Crystals of the Urokinase Type Plasminogen Activator Variant Beta(C)-Upain Complex with Small Molecule Inhibitors Open the Way Towards Structure-Based Drug Design. J.Mol.Biol. V. 301 465 2000.
ISSN: ISSN 0022-2836
PubMed: 10926521
DOI: 10.1006/JMBI.2000.3966
Page generated: Fri Jul 19 21:54:24 2024

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