Atomistry » Chlorine » PDB 1eyz-1g0g » 1fcm
Atomistry »
  Chlorine »
    PDB 1eyz-1g0g »
      1fcm »

Chlorine in PDB 1fcm: Crystal Structure of the E.Coli Ampc Beta-Lactamase Mutant Q120L/Y150E Covalently Acylated with the Inhibitory Beta-Lactam, Cloxacillin

Enzymatic activity of Crystal Structure of the E.Coli Ampc Beta-Lactamase Mutant Q120L/Y150E Covalently Acylated with the Inhibitory Beta-Lactam, Cloxacillin

All present enzymatic activity of Crystal Structure of the E.Coli Ampc Beta-Lactamase Mutant Q120L/Y150E Covalently Acylated with the Inhibitory Beta-Lactam, Cloxacillin:
3.5.2.6;

Protein crystallography data

The structure of Crystal Structure of the E.Coli Ampc Beta-Lactamase Mutant Q120L/Y150E Covalently Acylated with the Inhibitory Beta-Lactam, Cloxacillin, PDB code: 1fcm was solved by A.Patera, L.C.Blaszczak, B.K.Shoichet, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.46
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 118.520, 76.190, 98.280, 90.00, 116.68, 90.00
R / Rfree (%) 20.7 / 26.5

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the E.Coli Ampc Beta-Lactamase Mutant Q120L/Y150E Covalently Acylated with the Inhibitory Beta-Lactam, Cloxacillin (pdb code 1fcm). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the E.Coli Ampc Beta-Lactamase Mutant Q120L/Y150E Covalently Acylated with the Inhibitory Beta-Lactam, Cloxacillin, PDB code: 1fcm:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 1fcm

Go back to Chlorine Binding Sites List in 1fcm
Chlorine binding site 1 out of 2 in the Crystal Structure of the E.Coli Ampc Beta-Lactamase Mutant Q120L/Y150E Covalently Acylated with the Inhibitory Beta-Lactam, Cloxacillin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the E.Coli Ampc Beta-Lactamase Mutant Q120L/Y150E Covalently Acylated with the Inhibitory Beta-Lactam, Cloxacillin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl961

b:57.9
occ:1.00
CL A:CXU961 0.0 57.9 1.0
C29 A:CXU961 1.8 53.1 1.0
C30 A:CXU961 2.8 53.6 1.0
C28 A:CXU961 2.8 51.9 1.0
C26 A:CXU961 3.1 49.9 1.0
C22 A:CXU961 3.5 47.8 1.0
CD1 A:LEU117 3.7 23.4 1.0
C21 A:CXU961 3.7 46.8 1.0
N2 A:CXU961 3.8 45.4 1.0
N25 A:CXU961 3.9 49.6 1.0
CD2 A:LEU117 3.9 23.4 1.0
CD2 A:LEU116 4.0 32.6 1.0
S4 A:CXU961 4.0 49.2 1.0
C31 A:CXU961 4.1 54.6 1.0
C33 A:CXU961 4.1 52.5 1.0
CG A:LEU117 4.1 24.4 1.0
C23 A:CXU961 4.4 47.7 1.0
O21 A:CXU961 4.5 46.4 1.0
C32 A:CXU961 4.6 54.3 1.0
O24 A:CXU961 4.6 49.1 1.0
CG A:LEU116 4.8 30.8 1.0
C2 A:CXU961 4.9 43.9 1.0

Chlorine binding site 2 out of 2 in 1fcm

Go back to Chlorine Binding Sites List in 1fcm
Chlorine binding site 2 out of 2 in the Crystal Structure of the E.Coli Ampc Beta-Lactamase Mutant Q120L/Y150E Covalently Acylated with the Inhibitory Beta-Lactam, Cloxacillin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the E.Coli Ampc Beta-Lactamase Mutant Q120L/Y150E Covalently Acylated with the Inhibitory Beta-Lactam, Cloxacillin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl961

b:51.8
occ:1.00
CL B:CXU961 0.0 51.8 1.0
C29 B:CXU961 1.8 43.0 1.0
C30 B:CXU961 2.7 42.3 1.0
C28 B:CXU961 2.8 42.7 1.0
C26 B:CXU961 3.1 40.9 1.0
N2 B:CXU961 3.4 34.3 1.0
CD2 B:LEU117 3.4 26.6 1.0
C22 B:CXU961 3.5 39.3 1.0
C21 B:CXU961 3.5 37.6 1.0
S4 B:CXU961 3.8 26.4 1.0
CG B:LEU117 3.9 26.0 1.0
CD1 B:LEU117 3.9 24.9 1.0
C31 B:CXU961 4.0 43.7 1.0
N25 B:CXU961 4.1 40.5 1.0
C33 B:CXU961 4.1 41.6 1.0
CD2 B:LEU116 4.2 18.0 1.0
O21 B:CXU961 4.3 37.4 1.0
CG B:LEU116 4.4 22.8 1.0
C2 B:CXU961 4.4 29.0 1.0
C23 B:CXU961 4.5 40.1 1.0
C32 B:CXU961 4.6 43.4 1.0
C3 B:CXU961 4.7 29.1 1.0
O24 B:CXU961 4.8 41.3 1.0
CD1 B:LEU116 4.9 18.7 1.0

Reference:

A.Patera, L.C.Blaszczak, B.K.Shoichet. Crystal Structures of Substrate and Inhibitor Complexes with Ampc -Lactamase: Possible Implications For Substrate-Assisted Catalysis J.Am.Chem.Soc. V. 122 10504 2000.
ISSN: ISSN 0002-7863
DOI: 10.1021/JA001676X
Page generated: Thu Jul 10 16:52:12 2025

Last articles

Cl in 8BQQ
Cl in 8BQT
Cl in 8BRE
Cl in 8BQH
Cl in 8BQP
Cl in 8BOU
Cl in 8BOD
Cl in 8BOW
Cl in 8BOL
Cl in 8BO8
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy