Chlorine in PDB 1gq4: Structural Determinants of the Nherf Interaction with BETA2AR and Pdgfr

The structure of Structural Determinants of the Nherf Interaction with BETA2AR and Pdgfr, PDB code: 1gq4 was solved by S.Karthikeyan, T.Leung, J.A.A.Ladias, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.48 / 1.90
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	50.373, 50.373, 66.631, 90.00, 90.00, 120.00
R / Rfree (%)	17.1 / 18.6

The binding sites of Chlorine atom in the Structural Determinants of the Nherf Interaction with BETA2AR and Pdgfr (pdb code 1gq4). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Structural Determinants of the Nherf Interaction with BETA2AR and Pdgfr, PDB code: 1gq4:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Structural Determinants of the Nherf Interaction with BETA2AR and Pdgfr


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structural Determinants of the Nherf Interaction with BETA2AR and Pdgfr within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1100 b:14.8 occ:1.00 N A:LEU41 3.4 11.0 1.0 CB A:ALA55 3.8 13.6 1.0 CA A:ARG40 3.9 12.1 1.0 CG A:ARG40 3.9 15.7 1.0 CB A:ARG40 4.0 13.4 1.0 C A:ARG40 4.1 11.3 1.0 CA A:LEU41 4.3 11.0 1.0 CG A:LEU41 4.3 12.3 1.0 CD2 A:LEU41 4.6 13.1 1.0 CB A:LEU41 4.9 11.2 1.0 O A:HOH2038 4.9 10.3 1.0 NE A:ARG40 4.9 17.3 1.0 CD A:ARG40 4.9 18.2 1.0

Chlorine binding site 2 out of 4 in the Structural Determinants of the Nherf Interaction with BETA2AR and Pdgfr


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structural Determinants of the Nherf Interaction with BETA2AR and Pdgfr within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1101 b:15.8 occ:1.00 ND2 A:ASN95 3.2 15.3 1.0 N A:ASP92 3.4 12.6 1.0 O A:HOH2005 3.4 27.8 1.0 CB A:VAL91 3.9 11.8 1.0 CA A:VAL91 4.0 12.0 1.0 CB A:ASP92 4.0 13.6 1.0 CB A:ASN95 4.1 15.3 1.0 CB A:ASP96 4.1 12.5 1.0 O A:ASP92 4.1 14.3 1.0 CG A:ASN95 4.1 16.6 1.0 C A:VAL91 4.2 12.4 1.0 CA A:ASP92 4.2 14.0 1.0 CG1 A:VAL91 4.4 13.0 1.0 C A:ASP92 4.6 14.5 1.0 O A:HOH2009 4.8 40.0 1.0 O A:HOH2097 4.9 47.3 1.0 N A:ASP96 4.9 13.6 1.0 C A:ASN95 4.9 14.6 1.0 O A:HOH2003 4.9 38.4 1.0 CG A:ASP96 5.0 13.5 1.0 OD2 A:ASP96 5.0 9.3 1.0

Chlorine binding site 3 out of 4 in the Structural Determinants of the Nherf Interaction with BETA2AR and Pdgfr


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structural Determinants of the Nherf Interaction with BETA2AR and Pdgfr within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1102 b:19.2 occ:1.00 O A:HOH2050 2.9 23.0 1.0 N A:ALA55 3.1 12.9 1.0 O A:HOH2038 3.1 10.3 1.0 CB A:ALA55 3.7 13.6 1.0 CA A:LEU54 3.7 14.7 1.0 C A:LEU54 3.9 13.3 1.0 CA A:ALA55 4.0 13.4 1.0 CD2 A:LEU54 4.0 17.9 1.0 CB A:LEU54 4.3 14.8 1.0 CG2 A:VAL42 4.3 14.0 1.0 CB A:VAL42 4.4 13.5 1.0 O A:LEU53 4.5 14.8 1.0 CG A:LEU54 4.8 17.1 1.0 N A:LEU54 4.9 14.2 1.0 O A:ALA55 5.0 15.0 1.0

Chlorine binding site 4 out of 4 in the Structural Determinants of the Nherf Interaction with BETA2AR and Pdgfr


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structural Determinants of the Nherf Interaction with BETA2AR and Pdgfr within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1103 b:23.1 occ:1.00 OD1 A:ASN22 3.2 31.7 1.0 O A:HOH2041 3.5 36.1 1.0 CG A:ASN22 4.1 28.9 1.0 ND2 A:ASN22 4.1 31.3 1.0 O A:HOH2039 4.5 14.0 1.0

S.Karthikeyan, T.Leung, J.A.A.Ladias. Structural Determinants of the Na+/H+ Exchanger Regulatory Factor Interaction with the Beta 2 Adrenergic and Platelet-Derived Growth Factor Receptors J.Biol.Chem. V. 277 18973 2002.
ISSN: ISSN 0021-9258
PubMed: 11882663
DOI: 10.1074/JBC.M201507200